Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about NOXA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
NOXA is a gene implicated in neurodegeneration research. Key relationships include: activates, therapeutic target, interacts with. Associated with Aging, Als, Cancer. Connected to 32 entities in the SciDEX knowledge graph.
| Gene Symbol | PMAIP1 |
| Full Name | PMA-Induced mRNA 1 |
| Chromosome | 18q21.32 |
| Function | is a critical pro-apoptotic BH3-only protein that functions as a potent inducer of apoptosis. |
| Primary Expression | Ubiquitous; high expression in brain, especially in neurons |
| Amino Acids | 193 aa |
| Pathways | NF-κB |
| UniProt ID | Q9Y2X9 |
| NCBI Gene ID | 5366 |
| Ensembl ID | ENSG00000141682 |
| OMIM | 604958 |
| GeneCards | PMAIP1 |
| Human Protein Atlas | PMAIP1 |
| Alternative Names | NOXA, APR, PMD |
| Tissue | Expression Level |
| Interactions | BAX, PITX3, BCL2, MDM2, CDK4, ATF4 |
| KG Connections | 31 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
NOXA["<b>NOXA</b>"]
Parkinson{"Parkinson"}
NOXA -->|"expressed in"| Parkinson
Cancer{"Cancer"}
NOXA -->|"activates"| Cancer
BAX["BAX"]
NOXA -->|"inhibits"| BAX
PITX3["PITX3"]
NOXA -->|"activates"| PITX3
BCL2["BCL2"]
NOXA -->|"activates"| BCL2
Apoptosis(["Apoptosis"])
NOXA -->|"inhibits"| Apoptosis
APOPTOSIS["APOPTOSIS"]
NOXA -->|"interacts with"| APOPTOSIS
BCL_2["BCL-2"]
NOXA -->|"interacts with"| BCL_2
NOXA -->|"interacts with"| Apoptosis
MDM2["MDM2"]
NOXA -->|"activates"| MDM2
NOXA -->|"activates"| APOPTOSIS
CDK4["CDK4"]
NOXA -->|"activates"| CDK4
PROTEASOME_INHIBITION["PROTEASOME INHIBITION"]
PROTEASOME_INHIBITION -->|"activates"| NOXA
style NOXA fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Parkinson | expressed_in | disease | 0.65 |
| Cancer | activates | disease | 0.65 |
| Cancer | therapeutic_target | disease | 0.65 |
| Aging | therapeutic_target | disease | 0.65 |
| Als | therapeutic_target | disease | 0.65 |
| Carcinoma | therapeutic_target | disease | 0.65 |
| Gastric Cancer | therapeutic_target | disease | 0.65 |
| BAX | inhibits | gene | 0.60 |
| PITX3 | activates | gene | 0.60 |
| BCL2 | activates | gene | 0.60 |
| MDM2 | activates | gene | 0.60 |
| CDK4 | activates | gene | 0.60 |
| ATF4 | activates | gene | 0.60 |
| CHOP | activates | gene | 0.60 |
| PUMA | activates | gene | 0.60 |
| DRP1 | therapeutic_target | gene | 0.60 |
| Apoptosis | inhibits | pathway | 0.60 |
| APOPTOSIS | interacts_with | gene | 0.60 |
| BCL-2 | interacts_with | gene | 0.60 |
| Apoptosis | interacts_with | pathway | 0.60 |
| APOPTOSIS | activates | gene | 0.60 |
| Proteasome | activates | pathway | 0.60 |
| Unfolded Protein Response | activates | pathway | 0.60 |
| Apoptosis | activates | pathway | 0.60 |
| CANCER | therapeutic_target | gene | 0.60 |
| MITOCHONDRIA | therapeutic_target | gene | 0.60 |
| Mitophagy | therapeutic_target | pathway | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| BAX | activates | gene | 0.60 |
| PINK1 | therapeutic_target | gene | 0.60 |
| PROTEASOME INHIBITION | activates | gene | 0.60 |
| MITOPHAGY | therapeutic_target | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||