protein

PUMA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PUMA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

260Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

PUMA is a protein involved in neurodegeneration research. Key relationships include: associated with, activates, regulates. Associated with Aging, Als, Alzheimer. Connected to 179 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	BBC3
Full Name	BCL2 Binding Component 3 (PUMA)
Aliases	BBC3 gene encoding PUMA
Chromosome	19q13.32
Function	Unlike anti-apoptotic Bcl-2 proteins or pro-apoptotic Bax/Bak proteins, BH3-only proteins contain only the BH3 (Bcl-2 Homology 3) domain, which is essential for their pro-apoptotic function.
Amino Acids	193 aa
UniProt ID	[Q9BXW1](https://www.uniprot.org/uniprotkb/Q9BXW1/entry)
Ensembl ID	ENSG00000100711
GeneCards	BBC3
Human Protein Atlas	BBC3
Associated Diseases	Alzheimer's disease, Parkinson's disease
Interactions	ATP
KG Connections	11 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    PUMA["PUMA"]
    PUMA -->|"activates"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    PUMA -->|"activates"| Neurodegeneration["Neurodegeneration"]
    PUMA -->|"activates"| Dementia["Dementia"]
    PUMA -->|"activates"| Als["Als"]
    PUMA -->|"activates"| Ms["Ms"]
    PUMA -->|"regulates"| Frontotemporal_Dementia["Frontotemporal Dementia"]
    PUMA -->|"regulates"| Ftd["Ftd"]
    P53["P53"] -->|"activates"| PUMA
    DDIT3["DDIT3"] -->|"upregulates"| PUMA
    C9ORF72_REPEAT_EXPANSION["C9ORF72 REPEAT EXPANSION"] -->|"activates"| PUMA
    C9ORF72["C9ORF72"] -->|"activates"| PUMA
    DLK["DLK"] -->|"activates"| PUMA
    MDM2["MDM2"] -->|"regulates"| PUMA
    PIK3CA["PIK3CA"] -->|"regulates"| PUMA

Outgoing (154)

Target	Relation	Type	Str
apoptosis	activates	process	0.90
hematopoietic stem cells	modulates	cell_type	0.80
Apoptosis	activates	pathway	0.80
Neurodegeneration	activates	disease	0.75
Als	activates	disease	0.75
Cancer	therapeutic_target	disease	0.75
Mapk	activates	pathway	0.70
Blood-Brain Barrier	activates	pathway	0.70
CANCER	therapeutic_target	gene	0.70
Stem Cell	activates	pathway	0.70
Proteasome	activates	pathway	0.70
Amyotrophic Lateral Sclerosis	activates	disease	0.65
Dementia	activates	disease	0.65
Lymphoma	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Ms	activates	disease	0.65
Als	regulates	disease	0.65
Amyotrophic Lateral Sclerosis	regulates	disease	0.65
Dementia	regulates	disease	0.65
Frontotemporal Dementia	regulates	disease	0.65
Ftd	regulates	disease	0.65
Senescence	regulates	disease	0.65
Cancer	regulates	disease	0.65
Tumor	regulates	disease	0.65
Tumor	therapeutic_target	disease	0.65
Frontotemporal Dementia	activates	disease	0.65
Alzheimer	inhibits	disease	0.65
Als	associated_with	disease	0.65
Ischemia	activates	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Parkinson	activates	disease	0.65
Aging	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Gastric Cancer	therapeutic_target	disease	0.65
Breast Cancer	treats	disease	0.65
Cancer	associated_with	disease	0.65
Als	treats	disease	0.65
Ms	inhibits	disease	0.65
Dementia	encodes	disease	0.65
Frontotemporal Dementia	encodes	disease	0.65
Amyotrophic Lateral Sclerosis	encodes	disease	0.65
Als	encodes	disease	0.65
NEURODEGENERATION	causes	phenotype	0.64
C9ORF72	activates	gene	0.60
SIGMAR1	associated_with	gene	0.60
CHOP	associated_with	gene	0.60
VEGF	associated_with	gene	0.60
BECLIN1	associated_with	gene	0.60

Incoming (106)

Source	Relation	Type	Str
P53	activates	protein	1.00
TP53	activates	gene	0.90
P53	upstream_of	gene	0.85
DDIT3	upregulates	gene	0.80
APOPTOSIS	activates	gene	0.80
BAX	activates	gene	0.70
NEURODEGENERATION	activates	gene	0.70
VEGF	associated_with	gene	0.60
BAX	associated_with	gene	0.60
FIS1	associated_with	gene	0.60
TRAF6	associated_with	gene	0.60
CHOP	associated_with	gene	0.60
NRF2	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
BECLIN1	associated_with	gene	0.60
BCL2	associated_with	gene	0.60
TAAR1	associated_with	gene	0.60
SIGMAR1	associated_with	gene	0.60
MYD88	associated_with	gene	0.60
C9ORF72	activates	gene	0.60
PI3K	associated_with	gene	0.60
AKT	associated_with	gene	0.60
C9ORF72	regulates	gene	0.60
DLK	activates	gene	0.60
MDM2	regulates	gene	0.60
PIK3CA	regulates	gene	0.60
GAIN	regulates	gene	0.60
SIRT1	regulates	gene	0.60
SRC	regulates	gene	0.60
BAX	regulates	gene	0.60
BAX	interacts_with	gene	0.60
BAD	interacts_with	gene	0.60
BCL2	interacts_with	gene	0.60
BAD	regulates	gene	0.60
LIMK1	inhibits	gene	0.60
COFILIN	inhibits	gene	0.60
STAT3	activates	gene	0.60
PI3K	activates	gene	0.60
PINK1	therapeutic_target	gene	0.60
NOXA	activates	gene	0.60
PTEN	treats	gene	0.60
AKT1	treats	gene	0.60
ESR1	treats	gene	0.60
AKT	activates	entity	0.60
BCL2	activates	entity	0.60
BECLIN1	activates	entity	0.60
CHOP	activates	entity	0.60
FIS1	activates	entity	0.60
MTOR	activates	entity	0.60
MYD88	activates	entity	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

PUMA

Understanding Entity Pages

Summary

Wiki Pages (21)

BBC3 — BCL2 Binding Component 3 (PUMA)

cbs-psp-daily-action-plan

DNA Damage Response in Corticobasal Syndrome

FOXO1 Protein

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Vestibular Function Testing in Corticobasal Syndrome

Cytochrome c Protein

FOXO4 — Forkhead Box O4

MAPK/ERK Signaling Pathway in Neurodegeneration

Apoptosis Pathway in Neurodegeneration

Apoptosis in Neurodegeneration

ATF3 Protein

DNA Damage Response in Corticobasal Syndrome

Interferon Signaling in Neurodegeneration

Neuronal Network Dysfunction Pathway in Neurodegeneration

Cell Death Pathways in 4R-Tauopathies

Viral Involvement in Neurodegeneration Pathway

JNK/p38 MAPK Signaling Pathway in Neurodegeneration

CDK6 Protein