concept

PROTEASOME INHIBITION

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PROTEASOME INHIBITION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

71Connections

0Hypotheses

0Analyses

41Outgoing

26Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	PROTEASOME INHIBITION
Key Genes/Proteins	CASP3, UBIQUITIN, P62, AUTOPHAGY, KEAP1
Related Diseases	Ms, Cancer, Tumor, Myeloma, Parkinson
Related Pathways	Proteasome, Apoptosis

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    PROTEASOME_INHIBITION["PROTEASOME INHIBITION"]
    PROTEASOME_INHIBITION -->|"activates"| CASP3["CASP3"]
    PROTEASOME_INHIBITION -->|"activates"| Proteasome["Proteasome"]
    PROTEASOME_INHIBITION -->|"inhibits"| Apoptosis["Apoptosis"]
    PROTEASOME_INHIBITION -->|"contributes to"| Ms["Ms"]
    PROTEASOME_INHIBITION -->|"activates"| Cancer["Cancer"]
    PROTEASOME_INHIBITION -->|"inhibits"| Tumor["Tumor"]
    PROTEASOME_INHIBITION -->|"expressed in"| Myeloma["Myeloma"]
    PROTEASOME_INHIBITION -->|"activates"| Parkinson["Parkinson"]
    PROTEASOME_INHIBITION -->|"activates"| Als["Als"]
    HDAC6["HDAC6"] -->|"contributes to"| PROTEASOME_INHIBITION
    NFKB["NFKB"] -->|"inhibits"| PROTEASOME_INHIBITION
    MICROGLIA["MICROGLIA"] -->|"inhibits"| PROTEASOME_INHIBITION
    P62["P62"] -->|"activates"| PROTEASOME_INHIBITION
    KEAP1["KEAP1"] -->|"degrades"| PROTEASOME_INHIBITION
    NRF2["NRF2"] -->|"degrades"| PROTEASOME_INHIBITION
    AUTOPHAGY["AUTOPHAGY"] -->|"activates"| PROTEASOME_INHIBITION
    UBIQUITIN["UBIQUITIN"] -->|"degrades"| PROTEASOME_INHIBITION

Outgoing (45)

Target	Relation	Type	Str
CASP3	activates	gene	0.90
Proteasome	activates	pathway	0.70
Apoptosis	inhibits	pathway	0.70
Apoptosis	activates	pathway	0.70
Ms	contributes_to	disease	0.65
Cancer	activates	disease	0.65
Tumor	inhibits	disease	0.65
Myeloma	expressed_in	disease	0.65
Parkinson	activates	disease	0.65
Als	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
UBIQUITIN	contributes_to	gene	0.60
P62	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
KEAP1	contributes_to	gene	0.60
NRF2	contributes_to	gene	0.60
Ubiquitin-Proteasome	contributes_to	pathway	0.60
Autophagy	activates	pathway	0.60
NFKBIA	inhibits	gene	0.60
ASTROCYTES	inhibits	gene	0.60
NF-ΚB	inhibits	gene	0.60
APOPTOSIS	inhibits	gene	0.60
Proteasome	inhibits	pathway	0.60
Nf-Κb	inhibits	pathway	0.60
NOXA	activates	gene	0.60
MDM2	inhibits	gene	0.60
APOPTOSIS	activates	gene	0.60
CDK4	activates	gene	0.60
ATF4	inhibits	gene	0.60
CHOP	inhibits	gene	0.60
Unfolded Protein Response	activates	pathway	0.60
UBIQUITIN	degrades	gene	0.60
NRF2	degrades	gene	0.60
Ubiquitin-Proteasome	degrades	pathway	0.60
HDAC6	degrades	gene	0.60
Autophagy	inhibits	pathway	0.60
Cell Cycle	inhibits	pathway	0.60
Unfolded Protein Response	inhibits	pathway	0.60
Proteasome	expressed_in	pathway	0.60
Stem Cell	activates	pathway	0.60
AND	degrades	gene	0.60

Incoming (26)

Source	Relation	Type	Str
HDAC6	contributes_to	gene	0.60
NFKB	inhibits	gene	0.60
MICROGLIA	inhibits	gene	0.60
P62	activates	gene	0.60
KEAP1	degrades	gene	0.60
HDAC6	degrades	gene	0.60
NRF2	degrades	gene	0.60
AUTOPHAGY	activates	gene	0.60
UBIQUITIN	degrades	gene	0.60
AUTOPHAGY	inhibits	gene	0.60
APOPTOSIS	inhibits	gene	0.60
UBIQUITIN	inhibits	gene	0.60
CD4	inhibits	gene	0.60
BAX	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
PARKINSON	activates	gene	0.60
P53	activates	gene	0.60
PUMA	activates	gene	0.60
MDM2	activates	gene	0.60
KEAP1	contributes_to	gene	0.60
NRF2	contributes_to	gene	0.60
AND	contributes_to	gene	0.60
UBIQUITIN	contributes_to	gene	0.60
AND	degrades	gene	0.60
Autophagy	activates	process	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

PROTEASOME INHIBITION

Understanding Entity Pages

Wiki Pages (20)

cbs-psp-daily-action-plan

ftd-tdp-pathology

Histamine

proteasome-ubiquitin-system-dysfunction-parkinsons

SNCA→Alpha-synuclein→Aggregation→Lewy Bodies→Synucleinopathies Causal Chain

ubiquitin-proteasome-dysfunction-neurodegeneration

Proteostasis Network Dysfunction Comparison Across Neurodegenerative Diseases

Autophagy Failure Comparison -- AD/PD/ALS/FTD/HD

SERPINA3 Gene — Alpha-1 Antichymotrypsin in Neurodegeneration

ALS RNA Metabolism and Proteostasis Failure

Ubiquitin-Proteasome System Dysfunction in Neurodegeneration

Shared Proteinostasis Failure in Alzheimer's and Parkinson's Disease

c9orf72-expansion

jnk-p38-mapk-parkinsons

NF-κB Signaling in Neurodegeneration

Ubiquitin-Proteasome System Dysfunction in Parkinson's Disease

SOD1 Superoxide Dismutase 1 ALS Causal Chain

Nucleocytoplasmic Transport Defects in Neurodegenerative Diseases