gene

OGDH

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about OGDH: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

43Connections

0Hypotheses

1Analyses

29Outgoing

14Incoming

0Experiments

1Debates

Summary

OGDH encodes the E1 subunit of alpha-ketoglutarate dehydrogenase, a key TCA cycle enzyme deficient in Alzheimer's and Parkinson's disease.

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🧬 Gene Info

Gene Symbol	OGDH
Full Name	Oxoglutarate Dehydrogenase
Chromosome	7p13
Protein Family	2-oxoacid dehydrogenase family
Protein Type	Enzyme
Function	is a critical metabolic enzyme whose activity is significantly reduced in aging brain and in neurodegenerative diseases including Alzheimer's disease (AD) and Parkinson's disease (PD).
Gene Type	Protein-coding
Pathways	Lipid Metabolism
UniProt ID	Q02218
NCBI Gene ID	4967
Ensembl ID	ENSG00000105953
OMIM	203740
GeneCards	OGDH
Human Protein Atlas	OGDH
Neurotransmitter synthesis	Succinyl-CoA is a precursor for heme synthesis
Associated Diseases	Alzheimer's disease, Parkinson's disease
Interactions	DNA, GBA, LRRK2, MITOCHONDRIAL DYSFUNCTION, MTORC1, OGDHL
KG Connections	43 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: OGDH — AlphaFold Q02218 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

OGDH — Oxoglutarate Dehydrogenase

gene · 1255 words

→

OGDHL — Oxoglutarate Dehydrogenase Like

gene · 523 words

→

Pathway Diagram

graph TD
    OGDH["OGDH"]
    Als{"Als"}
    OGDH -->|"therapeutic target"| Als
    Parkinson{"Parkinson"}
    OGDH -->|"therapeutic target"| Parkinson
    Autoimmune{"Autoimmune"}
    OGDH -->|"therapeutic target"| Autoimmune
    PINK1["PINK1"]
    OGDH -->|"associated with"| PINK1
    neurodegeneration["neurodegeneration"]
    OGDH -->|"implicated in"| neurodegeneration
    OGDHL["OGDHL"]
    OGDHL -->|"interacts with"| OGDH
    PTEN["PTEN"]
    PTEN -->|"associated with"| OGDH
    LRRK2["LRRK2"]
    LRRK2 -->|"associated with"| OGDH
    GBA["GBA"]
    GBA -->|"associated with"| OGDH
    PINK1 -->|"associated with"| OGDH
    PARKIN["PARKIN"]
    PARKIN -->|"associated with"| OGDH
    SOD1["SOD1"]
    SOD1 -->|"associated with"| OGDH
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    PARKINSON_S_DISEASE -->|"therapeutic target"| OGDH
    UBIQUITIN["UBIQUITIN"]
    UBIQUITIN -->|"associated with"| OGDH
    style OGDH fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (29)

Target	Relation	Type	Str
Liver Cancer	therapeutic_target	disease	0.65
Carcinoma	activates	disease	0.65
Tumor	inhibits	disease	0.65
Hepatocellular Carcinoma	activates	disease	0.65
Cancer	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Autoimmune	therapeutic_target	disease	0.65
LRRK2	associated_with	gene	0.60
SOD1	activates	gene	0.60
PINK1	activates	gene	0.60
PTEN	activates	gene	0.60
PINK1	associated_with	gene	0.60
UBIQUITIN	associated_with	gene	0.60
SOD1	associated_with	gene	0.60
GBA	associated_with	gene	0.60
PARKIN	associated_with	gene	0.60
IL-10	therapeutic_target	gene	0.60
T Cell	therapeutic_target	cell_type	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
IFN	therapeutic_target	gene	0.60
Mitochondrial Function	inhibits	pathway	0.60
MTORC1	activates	gene	0.60
Lipid Metabolism	regulates	pathway	0.60
CANCER	therapeutic_target	gene	0.60
MITOCHONDRIAL DYSFUNCTION	inhibits	gene	0.60
DNA	activates	gene	0.60
Mtor	activates	pathway	0.60
alpha-KG/succinate ratio	regulates	process	0.50

Incoming (14)

Source	Relation	Type	Str
OGDHL	interacts_with	gene	0.90
OGDHL	inhibits	gene	0.60
PTEN	associated_with	gene	0.60
LRRK2	associated_with	gene	0.60
GBA	associated_with	gene	0.60
PINK1	associated_with	gene	0.60
PARKIN	associated_with	gene	0.60
SOD1	associated_with	gene	0.60
GBA	activates	gene	0.60
LRRK2	activates	gene	0.60
PARKINSON'S DISEASE	therapeutic_target	gene	0.60
PARKINSON	therapeutic_target	gene	0.60
HLA	therapeutic_target	gene	0.60
UBIQUITIN	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Which metabolic biomarkers can distinguish therapeutic response from disease pro

translational neuroscience | 2026-04-04 | 2 hypotheses Top: 0.532

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

Which metabolic biomarkers can distinguish therapeutic response from disease pro

closed · Rounds: 4 · Score: 0.77 · 2026-04-12

Related Research

Hypotheses and analyses mentioning OGDH in their description or question text

No additional research found