OGDH

Understanding Entity Pages

This page aggregates everything SciDEX knows about OGDH: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

OGDH encodes the E1 subunit of alpha-ketoglutarate dehydrogenase, a key TCA cycle enzyme deficient in Alzheimer's and Parkinson's disease.

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graph TD
    OGDH["<b>OGDH</b>"]
    Als{"Als"}
    OGDH -->|"therapeutic target"| Als
    Parkinson{"Parkinson"}
    OGDH -->|"therapeutic target"| Parkinson
    Autoimmune{"Autoimmune"}
    OGDH -->|"therapeutic target"| Autoimmune
    PINK1["PINK1"]
    OGDH -->|"associated with"| PINK1
    neurodegeneration["neurodegeneration"]
    OGDH -->|"implicated in"| neurodegeneration
    OGDHL["OGDHL"]
    OGDHL -->|"interacts with"| OGDH
    PTEN["PTEN"]
    PTEN -->|"associated with"| OGDH
    LRRK2["LRRK2"]
    LRRK2 -->|"associated with"| OGDH
    GBA["GBA"]
    GBA -->|"associated with"| OGDH
    PINK1 -->|"associated with"| OGDH
    PARKIN["PARKIN"]
    PARKIN -->|"associated with"| OGDH
    SOD1["SOD1"]
    SOD1 -->|"associated with"| OGDH
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    PARKINSON_S_DISEASE -->|"therapeutic target"| OGDH
    UBIQUITIN["UBIQUITIN"]
    UBIQUITIN -->|"associated with"| OGDH
    style OGDH fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0