gene

CDK6

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CDK6: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

76Connections
0Hypotheses
0Analyses
50Outgoing
15Incoming

Summary

Cyclin-Dependent Kinase 6 - cell cycle and neurodegeneration

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🧬 Gene Info
Gene SymbolCDK6
AliasesCyclin-Dependent Kinase 6
Protein TypeSerine/Threonine Kinase
FunctionThe CDK6 gene encodes Cyclin-Dependent Kinase 6, a 326-amino acid serine/threonine kinase
Primary Expressiongliomas, lymphomas, and carcinomas
Molecular Weight37 kDa
Amino Acids326 aa
Ensembl IDENSG00000105810
GeneCardsCDK6
Human Protein AtlasCDK6
Cell Cycle G1/S TransitionPhosphorylates retinoblastoma protein (Rb), releasing E2F transcription factors to activate S-phase genes[@lim2013].
Cellular DifferentiationRegulates differentiation of various cell types including neurons, osteoblasts, and adipocytes.
Transcriptional RegulationControls gene expression through phosphorylation of transcription factors and chromatin modifiers.
DNA Damage ResponseInvolved in DNA damage checkpoints and repair.
Synaptic PlasticityRegulates synaptic protein synthesis and dendritic spine morphology.
Associated DiseasesAls, Cancer, Carcinoma, Tumor
InteractionsRAB7A, AKT, CDK4, AUTOPHAGY-RELATED GENES, AUTOPHAGY, PIK3CA
KG Connections76 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Wiki Pages (17)

Knowledge base pages for this entity

Canonical Page

CDK6 Gene

gene · 537 words

CDK6 Protein

protein · 2710 words

CDKN2A Protein

protein · 2330 words

Sporadic ALS Initiation Biology: Deep Phenotyping of At-Risk Cohorts

experiment · 1943 words

HSP90AB1 Gene

gene · 1841 words

CHD8 Gene

gene · 1830 words

Pathway Diagram

graph TD
    CDK6["<b>CDK6</b>"]
    Ms{"Ms"}
    CDK6 -->|"expressed in"| Ms
    CDK6 -->|"therapeutic target"| Ms
    Cancer{"Cancer"}
    CDK6 -->|"therapeutic target"| Cancer
    Carcinoma{"Carcinoma"}
    CDK6 -->|"associated with"| Carcinoma
    Als{"Als"}
    CDK6 -->|"associated with"| Als
    CDK6 -->|"associated with"| Cancer
    Tumor{"Tumor"}
    CDK6 -->|"associated with"| Tumor
    GENES["GENES"]
    CDK6 -->|"expressed in"| GENES
    DNA["DNA"]
    CDK6 -->|"expressed in"| DNA
    PAX6["PAX6"]
    CDK6 -->|"regulates"| PAX6
    Cell_Cycle(["Cell Cycle"])
    CDK6 -->|"expressed in"| Cell_Cycle
    PRKCB["PRKCB"]
    CDK6 -->|"therapeutic target"| PRKCB
    AMBRA1["AMBRA1"]
    AMBRA1 -->|"inhibits"| CDK6
    PAX6 -->|"regulates"| CDK6
    MAPK3["MAPK3"]
    MAPK3 -->|"therapeutic target"| CDK6
    PIK3CA["PIK3CA"]
    PIK3CA -->|"inhibits"| CDK6
    DNA -->|"expressed in"| CDK6
    GENES -->|"expressed in"| CDK6
    AND["AND"]
    AND -->|"regulates"| CDK6
    style CDK6 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (61)

TargetRelationTypeStr
Tumorimplicated_indisease0.85
Cancertherapeutic_targetdisease0.75
CDK4therapeutic_targetgene0.70
CANCERtherapeutic_targetgene0.70
Msexpressed_indisease0.65

Incoming (15)

SourceRelationTypeStr
NRF2regulatesgene0.90
AMBRA1inhibitsprotein0.90
PAX6regulatesgene0.60
MAPK3therapeutic_targetgene0.60
PIK3CAinhibitsgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found