protein

PHOSPHORYLATED TAU

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PHOSPHORYLATED TAU: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

93Connections

0Hypotheses

0Analyses

46Outgoing

16Incoming

Summary

Page for Phosphorylated Tau Protein

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🔬 Protein Info

Gene Symbol	PHOSPHORYLATED TAU
Pathways	AMPK
Associated Diseases	Alzheimer Disease, Alzheimer'S Disease, Neuronal loss, Tauopathy, aging, disease
Interactions	BETA-AMYLOID, ALZHEIMER, AMYLOID, AQP4, PHAGOCYTOSIS, APOE
KG Connections	62 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    PHOSPHORYLATED_TAU["<b>PHOSPHORYLATED TAU</b>"]
    ALZHEIMER["ALZHEIMER"]
    PHOSPHORYLATED_TAU -->|"associated with"| ALZHEIMER
    Alzheimer_S_Disease["Alzheimer'S Disease"]
    PHOSPHORYLATED_TAU -->|"associated with"| Alzheimer_S_Disease
    AMYLOID["AMYLOID"]
    PHOSPHORYLATED_TAU -->|"associated with"| AMYLOID
    disease["disease"]
    PHOSPHORYLATED_TAU -->|"associated with"| disease
    ALZHEIMER_S["ALZHEIMER'S"]
    PHOSPHORYLATED_TAU -->|"associated with"| ALZHEIMER_S
    AMYLOID__["AMYLOID-beta"]
    PHOSPHORYLATED_TAU -->|"associated with"| AMYLOID__
    NEUROFIBRILLARY_TANGLES["NEUROFIBRILLARY TANGLES"]
    PHOSPHORYLATED_TAU -->|"associated with"| NEUROFIBRILLARY_TANGLES
    NEURONS["NEURONS"]
    PHOSPHORYLATED_TAU -->|"associated with"| NEURONS
    AMYLOID___PLAQUES["AMYLOID-Beta PLAQUES"]
    PHOSPHORYLATED_TAU -->|"associated with"| AMYLOID___PLAQUES
    BETA_AMYLOID["BETA-AMYLOID"]
    PHOSPHORYLATED_TAU -->|"activates"| BETA_AMYLOID
    ALZHEIMER["ALZHEIMER"]
    PHOSPHORYLATED_TAU -->|"activates"| ALZHEIMER
    Alzheimer_S_Disease["Alzheimer'S Disease"]
    PHOSPHORYLATED_TAU -->|"activates"| Alzheimer_S_Disease
    AMYLOID["AMYLOID"]
    PHOSPHORYLATED_TAU -->|"activates"| AMYLOID
    disease["disease"]
    PHOSPHORYLATED_TAU -->|"activates"| disease
    ALZHEIMER_S["ALZHEIMER'S"]
    PHOSPHORYLATED_TAU -->|"activates"| ALZHEIMER_S
    BETA_AMYLOID["BETA-AMYLOID"]
    PHOSPHORYLATED_TAU -->|"associated with"| BETA_AMYLOID
    Neuroinflammatory["Neuroinflammatory"]
    PHOSPHORYLATED_TAU -->|"associated with"| Neuroinflammatory
    CEREBROSPINAL_FLUID["CEREBROSPINAL FLUID"]
    PHOSPHORYLATED_TAU -->|"associated with"| CEREBROSPINAL_FLUID
    AMYLOID_BETA["AMYLOID BETA"]
    PHOSPHORYLATED_TAU -->|"associated with"| AMYLOID_BETA
    Tauopathy["Tauopathy"]
    PHOSPHORYLATED_TAU -->|"associated with"| Tauopathy
    Astrocyte["Astrocyte"]
    PHOSPHORYLATED_TAU -->|"activates"| Astrocyte
    SYNAPSE["SYNAPSE"]
    PHOSPHORYLATED_TAU -->|"activates"| SYNAPSE
    aging["aging"]
    PHOSPHORYLATED_TAU -->|"associated with"| aging
    AMYLOID["AMYLOID"]
    PHOSPHORYLATED_TAU -->|"expressed in"| AMYLOID
    AMYLOID__["AMYLOID-beta"]
    PHOSPHORYLATED_TAU -->|"expressed in"| AMYLOID__
    Alzheimer_Disease["Alzheimer Disease"]
    PHOSPHORYLATED_TAU -->|"associated with"| Alzheimer_Disease
    Tauopathy["Tauopathy"]
    PHOSPHORYLATED_TAU -->|"activates"| Tauopathy
    GLIOSIS["GLIOSIS"]
    PHOSPHORYLATED_TAU -->|"activates"| GLIOSIS
    CEREBROSPINAL_FLUID["CEREBROSPINAL FLUID"]
    PHOSPHORYLATED_TAU -->|"activates"| CEREBROSPINAL_FLUID
    apoptosis["apoptosis"]
    PHOSPHORYLATED_TAU -->|"activates"| apoptosis

Outgoing (66)

Target	Relation	Type	Str
P62	co_expressed_with	protein	0.85
Neuronal loss	associated_with	phenotype	0.85
ALZHEIMER	associated_with	gene	0.50
Alzheimer'S Disease	associated_with	disease	0.50
AMYLOID	associated_with	gene	0.50
disease	associated_with	disease	0.50
ALZHEIMER'S	associated_with	concept	0.50
AMYLOID-β	associated_with	concept	0.50
NEUROFIBRILLARY TANGLES	associated_with	concept	0.50
NEURONS	associated_with	concept	0.50
AMYLOID-Β PLAQUES	associated_with	gene	0.50
BETA-AMYLOID	activates	protein	0.50
ALZHEIMER	activates	gene	0.50
Alzheimer'S Disease	activates	disease	0.50
AMYLOID	activates	gene	0.50
disease	activates	disease	0.50
ALZHEIMER'S	activates	concept	0.50
BETA-AMYLOID	associated_with	protein	0.50
Neuroinflammatory	associated_with	pathway	0.50
CEREBROSPINAL FLUID	associated_with	concept	0.50
AMYLOID BETA	associated_with	concept	0.50
Tauopathy	associated_with	disease	0.50
Astrocyte	activates	cell_type	0.50
SYNAPSE	activates	concept	0.50
aging	associated_with	phenotype	0.50
AMYLOID	expressed_in	gene	0.50
AMYLOID-β	expressed_in	concept	0.50
Alzheimer Disease	associated_with	disease	0.50
Tauopathy	activates	disease	0.50
GLIOSIS	activates	concept	0.50
CEREBROSPINAL FLUID	activates	concept	0.50
apoptosis	activates	process	0.50
Neuroinflammatory	activates	pathway	0.50
AMYLOID-β	activates	concept	0.50
Cortex	expressed_in	brain_region	0.50
White Matter	expressed_in	process	0.50
OLIGODENDROCYTES	expressed_in	concept	0.50
GRAY MATTER	expressed_in	concept	0.50
AMYLOID	interacts_with	gene	0.50
CYTOKINES	activates	concept	0.50
TAU PATHOLOGY	activates	concept	0.50
ENDOTHELIAL	activates	concept	0.50
Lysosomal Degradation	associated_with	pathway	0.50
SYNUCLEIN	associated_with	concept	0.50
Proteins	associated_with	protein	0.50
α-SYNUCLEIN	associated_with	concept	0.50

Incoming (27)

Source	Relation	Type	Str
proteasomal inhibition	downregulates	mechanism	0.87
Proteasome Inhibition	downregulates	mechanism	0.85
Neurodegeneration	interacts_with	disease	0.50
AQP4	interacts_with	gene	0.50
Neurodegeneration	associated_with	disease	0.50
PHAGOCYTOSIS	activates	gene	0.50
APOE	activates	gene	0.50
microglia	activates	cell_type	0.50
AMYLOID-BETA	associated_with	protein	0.50
late	regulates	disease	0.50
late	associated_with	disease	0.50
GFAP	associated_with	gene	0.50
Neurodegeneration	activates	disease	0.50
IL10	activates	gene	0.50
IL18	activates	gene	0.50
NEUROFILAMENT LIGHT CHAIN	activates	protein	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

PHOSPHORYLATED TAU

Understanding Entity Pages

Summary

Wiki Pages (20)

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Progressive Supranuclear Palsy (PSP)

Corticobasal Syndrome (CBS)

Sleep and Circadian Dysfunction in Alzheimer's Disease

Atypical Parkinsonism

Device Therapies Comparison for CBS/PSP

Myoclonus and Cortical Hyperexcitability in Corticobasal Syndrome

Corticobasal Degeneration (CBD)

nhp-validation-animal-model

Frontotemporal Dementia (FTD) Mechanistic Pathway

Alzheimer's Disease

Frontotemporal Dementia (FTD)

NTF4 Protein

TREM2 Mechanism Hub

Neuroimmune Response in 4R-Tauopathies: Cross-Disease Comparison

GSK-3β in Neurodegeneration

p-tau-217