Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SLC24A2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | SLC24A2 |
| Full Name | Solute Carrier Family 24 Member 2 (Na+/Ca2+ Exchanger 2) |
| Chromosome | 9p21 |
| Function | is a hallmark of many neurodegenerative diseases. |
| Primary Expression | the olfactory bulb, where it plays a critical role in olfactory receptor neuron function |
| Pathways | Apoptosis, Complement, Exocytosis, Mitochondrial Function |
| UniProt ID | O43295 |
| NCBI Gene ID | 8994 |
| Ensembl ID | ENSG00000159339 |
| OMIM | 609521 |
| GeneCards | SLC24A2 |
| Human Protein Atlas | SLC24A2 |
| Associated Diseases | neurodegeneration |
| Interactions | PDE4C, NGF |
| KG Connections | 33 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
SLC24A2["<b>SLC24A2</b>"]
Dementia{"Dementia"}
SLC24A2 -->|"regulates"| Dementia
Schizophrenia{"Schizophrenia"}
SLC24A2 -->|"regulates"| Schizophrenia
Alzheimer{"Alzheimer"}
SLC24A2 -->|"regulates"| Alzheimer
Multiple_Sclerosis{"Multiple Sclerosis"}
SLC24A2 -->|"regulates"| Multiple_Sclerosis
Als{"Als"}
SLC24A2 -->|"regulates"| Als
Cancer{"Cancer"}
SLC24A2 -->|"regulates"| Cancer
Ms{"Ms"}
SLC24A2 -->|"regulates"| Ms
APOPTOSIS["APOPTOSIS"]
SLC24A2 -->|"regulates"| APOPTOSIS
DNAJC2["DNAJC2"]
SLC24A2 -->|"regulates"| DNAJC2
CHMP3["CHMP3"]
SLC24A2 -->|"regulates"| CHMP3
PDE4C["PDE4C"]
SLC24A2 -->|"activates"| PDE4C
BAG1["BAG1"]
SLC24A2 -->|"regulates"| BAG1
NBN["NBN"]
NBN -->|"regulates"| SLC24A2
ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
ALZHEIMER_S_DISEASE -->|"regulates"| SLC24A2
SGK3["SGK3"]
SGK3 -->|"regulates"| SLC24A2
TNF["TNF"]
TNF -->|"regulates"| SLC24A2
CANCER["CANCER"]
CANCER -->|"regulates"| SLC24A2
style SLC24A2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Dementia | regulates | disease | 0.65 |
| Schizophrenia | regulates | disease | 0.65 |
| Alzheimer | regulates | disease | 0.65 |
| Multiple Sclerosis | regulates | disease | 0.65 |
| Als | regulates | disease | 0.65 |
| Cancer | regulates | disease | 0.65 |
| Ms | regulates | disease | 0.65 |
| DNAJC2 | regulates | gene | 0.60 |
| CHMP3 | regulates | gene | 0.60 |
| PDE4C | activates | gene | 0.60 |
| BAG1 | regulates | gene | 0.60 |
| VTI1B | regulates | gene | 0.60 |
| EIF4G1 | regulates | gene | 0.60 |
| NOX1 | regulates | gene | 0.60 |
| NGF | activates | gene | 0.60 |
| DISC1 | regulates | gene | 0.60 |
| GALNT3 | regulates | gene | 0.60 |
| IREB2 | regulates | gene | 0.60 |
| WEE1 | implicated_in | gene | 0.60 |
| APOPTOSIS | regulates | gene | 0.60 |
| COMPLEMENT | regulates | gene | 0.60 |
| Apoptosis | regulates | pathway | 0.60 |
| Exocytosis | regulates | pathway | 0.60 |
| Mitochondrial Function | regulates | pathway | 0.60 |
| Complement | regulates | pathway | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||