gene

IREB2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IREB2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

88Connections
0Hypotheses
0Analyses
50Outgoing
32Incoming

Summary

Page for IREB2 — Iron Responsive Element Binding Protein 2

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🧬 Gene Info
Gene SymbolIREB2
Full NameIron Responsive Element Binding Protein 2
Chromosome15q25.1
Functionis a central pathogenic mechanism in neurodegeneration.
Primary ExpressionHippocampus, Substantia nigra, Cortex, Basal ganglia (enriched in brain)
Molecular Weight105 kDa
Amino Acids963 aa
Exons22
PathwaysApoptosis, Complement, Exocytosis, Mitochondrial Function
UniProt IDP48200
NCBI Gene ID3658
Ensembl IDENSG00000136381
OMIM147582
GeneCardsIREB2
Human Protein AtlasIREB2
Associated DiseasesAlzheimer's Disease, Parkinson's Disease, NBIA, Neurodegeneration with brain iron accumulation
InteractionsDNAJA1, ATP1B1, ATP1B3, ABCB1, TP53, ALOX12
KG Connections88 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: IREB2 — AlphaFold P48200 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (13)

Knowledge base pages for this entity

Canonical Page

IREB2 — Iron Responsive Element Binding Protein 2

gene · 1556 words

Iron Homeostasis Dysregulation in Neurodegeneration

mechanism · 3324 words

Ferroptosis Hypothesis in Parkinson's Disease

hypothesis · 1893 words

atp1b3

gene · 1714 words

Iron Accumulation in Progressive Supranuclear Palsy

mechanism · 1702 words

Metal Homeostasis in Neurodegeneration

mechanism · 1682 words

Pathway Diagram

graph TD
    IREB2["<b>IREB2</b>"]
    Dementia{"Dementia"}
    IREB2 -->|"regulates"| Dementia
    Schizophrenia{"Schizophrenia"}
    IREB2 -->|"regulates"| Schizophrenia
    Alzheimer{"Alzheimer"}
    IREB2 -->|"regulates"| Alzheimer
    Multiple_Sclerosis{"Multiple Sclerosis"}
    IREB2 -->|"regulates"| Multiple_Sclerosis
    Als{"Als"}
    IREB2 -->|"regulates"| Als
    Cancer{"Cancer"}
    IREB2 -->|"regulates"| Cancer
    Ms{"Ms"}
    IREB2 -->|"regulates"| Ms
    DNAJA1["DNAJA1"]
    IREB2 -->|"interacts with"| DNAJA1
    ATP1B1["ATP1B1"]
    IREB2 -->|"interacts with"| ATP1B1
    ATP1B3["ATP1B3"]
    IREB2 -->|"interacts with"| ATP1B3
    ABCB1["ABCB1"]
    IREB2 -->|"interacts with"| ABCB1
    COMPLEMENT["COMPLEMENT"]
    IREB2 -->|"regulates"| COMPLEMENT
    NBN["NBN"]
    NBN -->|"regulates"| IREB2
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"regulates"| IREB2
    SGK3["SGK3"]
    SGK3 -->|"regulates"| IREB2
    TNF["TNF"]
    TNF -->|"regulates"| IREB2
    CANCER["CANCER"]
    CANCER -->|"regulates"| IREB2
    SLC24A2["SLC24A2"]
    SLC24A2 -->|"regulates"| IREB2
    APOPTOSIS["APOPTOSIS"]
    APOPTOSIS -->|"regulates"| IREB2
    DNAJC2["DNAJC2"]
    DNAJC2 -->|"regulates"| IREB2
    CHMP3["CHMP3"]
    CHMP3 -->|"activates"| IREB2
    PDE4C["PDE4C"]
    PDE4C -->|"regulates"| IREB2
    BAG1["BAG1"]
    BAG1 -->|"regulates"| IREB2
    VTI1B["VTI1B"]
    VTI1B -->|"regulates"| IREB2
    style IREB2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (56)

TargetRelationTypeStr
Dementiaregulatesdisease0.65
Schizophreniaregulatesdisease0.65
Alzheimerregulatesdisease0.65
Multiple Sclerosisregulatesdisease0.65
Alsregulatesdisease0.65

Incoming (32)

SourceRelationTypeStr
NBNregulatesgene0.60
SGK3regulatesgene0.60
TNFregulatesgene0.60
SLC24A2regulatesgene0.60
DNAJC2regulatesgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found