Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about IREB2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | IREB2 |
| Full Name | Iron Responsive Element Binding Protein 2 |
| Chromosome | 15q25.1 |
| Function | is a central pathogenic mechanism in neurodegeneration. |
| Primary Expression | Hippocampus, Substantia nigra, Cortex, Basal ganglia (enriched in brain) |
| Molecular Weight | 105 kDa |
| Amino Acids | 963 aa |
| Exons | 22 |
| Pathways | Apoptosis, Complement, Exocytosis, Mitochondrial Function |
| UniProt ID | P48200 |
| NCBI Gene ID | 3658 |
| Ensembl ID | ENSG00000136381 |
| OMIM | 147582 |
| GeneCards | IREB2 |
| Human Protein Atlas | IREB2 |
| Associated Diseases | Alzheimer's Disease, Parkinson's Disease, NBIA, Neurodegeneration with brain iron accumulation |
| Interactions | DNAJA1, ATP1B1, ATP1B3, ABCB1, TP53, ALOX12 |
| KG Connections | 88 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
IREB2["<b>IREB2</b>"]
Dementia{"Dementia"}
IREB2 -->|"regulates"| Dementia
Schizophrenia{"Schizophrenia"}
IREB2 -->|"regulates"| Schizophrenia
Alzheimer{"Alzheimer"}
IREB2 -->|"regulates"| Alzheimer
Multiple_Sclerosis{"Multiple Sclerosis"}
IREB2 -->|"regulates"| Multiple_Sclerosis
Als{"Als"}
IREB2 -->|"regulates"| Als
Cancer{"Cancer"}
IREB2 -->|"regulates"| Cancer
Ms{"Ms"}
IREB2 -->|"regulates"| Ms
DNAJA1["DNAJA1"]
IREB2 -->|"interacts with"| DNAJA1
ATP1B1["ATP1B1"]
IREB2 -->|"interacts with"| ATP1B1
ATP1B3["ATP1B3"]
IREB2 -->|"interacts with"| ATP1B3
ABCB1["ABCB1"]
IREB2 -->|"interacts with"| ABCB1
COMPLEMENT["COMPLEMENT"]
IREB2 -->|"regulates"| COMPLEMENT
NBN["NBN"]
NBN -->|"regulates"| IREB2
ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
ALZHEIMER_S_DISEASE -->|"regulates"| IREB2
SGK3["SGK3"]
SGK3 -->|"regulates"| IREB2
TNF["TNF"]
TNF -->|"regulates"| IREB2
CANCER["CANCER"]
CANCER -->|"regulates"| IREB2
SLC24A2["SLC24A2"]
SLC24A2 -->|"regulates"| IREB2
APOPTOSIS["APOPTOSIS"]
APOPTOSIS -->|"regulates"| IREB2
DNAJC2["DNAJC2"]
DNAJC2 -->|"regulates"| IREB2
CHMP3["CHMP3"]
CHMP3 -->|"activates"| IREB2
PDE4C["PDE4C"]
PDE4C -->|"regulates"| IREB2
BAG1["BAG1"]
BAG1 -->|"regulates"| IREB2
VTI1B["VTI1B"]
VTI1B -->|"regulates"| IREB2
style IREB2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Dementia | regulates | disease | 0.65 |
| Schizophrenia | regulates | disease | 0.65 |
| Alzheimer | regulates | disease | 0.65 |
| Multiple Sclerosis | regulates | disease | 0.65 |
| Als | regulates | disease | 0.65 |
| Cancer | regulates | disease | 0.65 |
| Ms | regulates | disease | 0.65 |
| Anxiety | activates | disease | 0.65 |
| Parkinson | activates | disease | 0.65 |
| Neurodegeneration | activates | disease | 0.65 |
| Alzheimer | inhibits | disease | 0.65 |
| Neuroinflammation | inhibits | disease | 0.65 |
| Inflammation | inhibits | disease | 0.65 |
| Ms | inhibits | disease | 0.65 |
| DNAJA1 | interacts_with | gene | 0.60 |
| ATP1B1 | interacts_with | gene | 0.60 |
| ATP1B3 | interacts_with | gene | 0.60 |
| ABCB1 | interacts_with | gene | 0.60 |
| TP53 | activates | gene | 0.60 |
| ALOX12 | activates | gene | 0.60 |
| TFR1 | activates | gene | 0.60 |
| P62 | inhibits | gene | 0.60 |
| DMT1 | expressed_in | gene | 0.60 |
| JNK | inhibits | gene | 0.60 |
| FTH1 | expressed_in | gene | 0.60 |
| SLC7A11 | expressed_in | gene | 0.60 |
| TFR1 | expressed_in | gene | 0.60 |
| COMPLEMENT | regulates | gene | 0.60 |
| Apoptosis | regulates | pathway | 0.60 |
| Exocytosis | regulates | pathway | 0.60 |
| Mitochondrial Function | regulates | pathway | 0.60 |
| Complement | regulates | pathway | 0.60 |
| PARKINSON | activates | gene | 0.60 |
| P53 | activates | gene | 0.60 |
| FERROPTOSIS | activates | gene | 0.60 |
| Ferroptosis | activates | pathway | 0.60 |
| FERROPTOSIS | expressed_in | gene | 0.60 |
| ALZHEIMER | inhibits | gene | 0.60 |
| AMYLOID | inhibits | gene | 0.60 |
| AND | expressed_in | gene | 0.60 |
| AUTOPHAGY | inhibits | gene | 0.60 |
| Ferroptosis | expressed_in | pathway | 0.60 |
| Autophagy | inhibits | pathway | 0.60 |
| Mapk | inhibits | pathway | 0.60 |
| ROS | inhibits | gene | 0.60 |
| GENES | expressed_in | gene | 0.60 |
| NEURODEGENERATIVE DISEASES | inhibits | gene | 0.60 |
| ALZHEIMER'S DISEASE | inhibits | gene | 0.60 |
| LC3B | inhibits | gene | 0.60 |
| INFLAMMATION | inhibits | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| NBN | regulates | gene | 0.60 |
| SGK3 | regulates | gene | 0.60 |
| TNF | regulates | gene | 0.60 |
| SLC24A2 | regulates | gene | 0.60 |
| DNAJC2 | regulates | gene | 0.60 |
| CHMP3 | activates | gene | 0.60 |
| PDE4C | regulates | gene | 0.60 |
| BAG1 | regulates | gene | 0.60 |
| VTI1B | regulates | gene | 0.60 |
| EIF4G1 | activates | gene | 0.60 |
| NOX1 | regulates | gene | 0.60 |
| NGF | regulates | gene | 0.60 |
| DISC1 | activates | gene | 0.60 |
| GALNT3 | regulates | gene | 0.60 |
| SLC7A11 | activates | gene | 0.60 |
| GPX4 | activates | gene | 0.60 |
| BECLIN1 | inhibits | gene | 0.60 |
| TAU | inhibits | gene | 0.60 |
| ALZHEIMER'S DISEASE | regulates | gene | 0.60 |
| CANCER | regulates | gene | 0.60 |
| APOPTOSIS | regulates | gene | 0.60 |
| NEURODEGENERATION | activates | gene | 0.60 |
| PARKINSON'S DISEASE | activates | gene | 0.60 |
| ANXIETY | activates | gene | 0.60 |
| INFLAMMATION | inhibits | gene | 0.60 |
| ALZHEIMER'S DISEASE | inhibits | gene | 0.60 |
| NEURODEGENERATIVE DISEASES | inhibits | gene | 0.60 |
| ROS | inhibits | gene | 0.60 |
| NEUROINFLAMMATION | inhibits | gene | 0.60 |
| LC3B | inhibits | gene | 0.60 |
| GENES | expressed_in | gene | 0.60 |
| FERROPTOSIS | activates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||