Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about NOX1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
NOX1 is a gene implicated in neurodegeneration research. Key relationships include: regulates, activates, interacts with. Associated with Als, Alzheimer, Atherosclerosis. Connected to 39 entities in the SciDEX knowledge graph.
| Gene Symbol | NOX1 |
| Full Name | NADPH Oxidase 1 |
| Chromosome | Xq22 |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | certain neuronal populations and glial cells within the brain |
| Molecular Weight | 65 kDa |
| Amino Acids | 564 aa |
| Pathways | Apoptosis, Complement, Exocytosis, Mitochondrial Function |
| UniProt ID | [Q9Y5S5](https://www.uniprot.org/uniprot/Q9Y5S5) |
| Ensembl ID | ENSG00000156508 |
| OMIM | 300225 |
| GeneCards | NOX1 |
| Human Protein Atlas | NOX1 |
| 6 transmembrane domains | Position heme groups for electron transfer |
| Dehydrogenase domain | Contains FAD and NADPH binding sites |
| Associated Diseases | Parkinson, Parkinson's Disease, disease, ferroptosis, neurodegeneration |
| Known Drugs/Compounds | rapamycin |
| Interactions | EGFR, EGF, OPTN, PPARGC1A, SIRT1, SQSTM1 |
| KG Connections | 107 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
NOX1["<b>NOX1</b>"]
Atherosclerosis{"Atherosclerosis"}
NOX1 -->|"interacts with"| Atherosclerosis
Dementia{"Dementia"}
NOX1 -->|"regulates"| Dementia
Schizophrenia{"Schizophrenia"}
NOX1 -->|"regulates"| Schizophrenia
Alzheimer{"Alzheimer"}
NOX1 -->|"regulates"| Alzheimer
Multiple_Sclerosis{"Multiple Sclerosis"}
NOX1 -->|"regulates"| Multiple_Sclerosis
Als{"Als"}
NOX1 -->|"regulates"| Als
Cancer{"Cancer"}
NOX1 -->|"regulates"| Cancer
Ms{"Ms"}
NOX1 -->|"regulates"| Ms
ERBB2["ERBB2"]
NOX1 -->|"interacts with"| ERBB2
EGFR["EGFR"]
NOX1 -->|"interacts with"| EGFR
Angiogenesis(["Angiogenesis"])
NOX1 -->|"interacts with"| Angiogenesis
NGF["NGF"]
NOX1 -->|"regulates"| NGF
EGF["EGF"]
EGF -->|"activates"| NOX1
NBN["NBN"]
NBN -->|"regulates"| NOX1
ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
ALZHEIMER_S_DISEASE -->|"regulates"| NOX1
SGK3["SGK3"]
SGK3 -->|"regulates"| NOX1
TNF["TNF"]
TNF -->|"regulates"| NOX1
CANCER["CANCER"]
CANCER -->|"regulates"| NOX1
SLC24A2["SLC24A2"]
SLC24A2 -->|"regulates"| NOX1
APOPTOSIS["APOPTOSIS"]
APOPTOSIS -->|"regulates"| NOX1
DNAJC2["DNAJC2"]
DNAJC2 -->|"regulates"| NOX1
CHMP3["CHMP3"]
CHMP3 -->|"regulates"| NOX1
PDE4C["PDE4C"]
PDE4C -->|"regulates"| NOX1
BAG1["BAG1"]
BAG1 -->|"regulates"| NOX1
style NOX1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| ds-83b31ef18d49 | provides_data_for | dataset | 1.00 |
| FERROPTOSIS | activates | entity | 0.88 |
| FERRITINOPHAGY | associated_with | entity | 0.85 |
| ROS | activates | gene | 0.70 |
| Atherosclerosis | interacts_with | disease | 0.65 |
| Dementia | regulates | disease | 0.65 |
| Schizophrenia | regulates | disease | 0.65 |
| Alzheimer | regulates | disease | 0.65 |
| Multiple Sclerosis | regulates | disease | 0.65 |
| Als | regulates | disease | 0.65 |
| Cancer | regulates | disease | 0.65 |
| Ms | regulates | disease | 0.65 |
| Inflammation | activates | disease | 0.65 |
| Neurodegeneration | activates | disease | 0.65 |
| Parkinson | contributes_to | disease | 0.65 |
| EGFR | interacts_with | gene | 0.60 |
| NGF | regulates | gene | 0.60 |
| DISC1 | regulates | gene | 0.60 |
| GALNT3 | regulates | gene | 0.60 |
| IREB2 | regulates | gene | 0.60 |
| EGF | activates | gene | 0.60 |
| Ferritin | contributes_to | protein | 0.60 |
| ferroptosis | participates_in | pathway | 0.60 |
| neurodegeneration | activates | disease | 0.60 |
| neurodegeneration | associated_with | disease | 0.60 |
| OPTN | activates | gene | 0.60 |
| PPARGC1A | activates | gene | 0.60 |
| SIRT1 | activates | gene | 0.60 |
| SQSTM1 | activates | gene | 0.60 |
| TFEB | activates | gene | 0.60 |
| TFRC | activates | gene | 0.60 |
| TUBG1 | activates | gene | 0.60 |
| ERBB2 | interacts_with | gene | 0.60 |
| Angiogenesis | interacts_with | pathway | 0.60 |
| COMPLEMENT | regulates | gene | 0.60 |
| Apoptosis | regulates | pathway | 0.60 |
| Exocytosis | regulates | pathway | 0.60 |
| Mitochondrial Function | regulates | pathway | 0.60 |
| Complement | regulates | pathway | 0.60 |
| INFLAMMATION | activates | gene | 0.60 |
| NEURODEGENERATION | activates | gene | 0.60 |
| GENES | associated_with | gene | 0.60 |
| PARKINSON | contributes_to | gene | 0.60 |
| AND | activates | gene | 0.60 |
| PARKINSON'S DISEASE | contributes_to | gene | 0.60 |
| Ferroptosis | activates | pathway | 0.60 |
| Dopaminergic | associated_with | cell_type | 0.60 |
| Neuron | associated_with | cell_type | 0.60 |
| App | associated_with | protein | 0.60 |
| Parkinson | associated_with | disease | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ds-83b31ef18d49 | data_in | dataset | 1.00 |
| EGF | activates | gene | 0.60 |
| NBN | regulates | gene | 0.60 |
| SGK3 | regulates | gene | 0.60 |
| TNF | regulates | gene | 0.60 |
| SLC24A2 | regulates | gene | 0.60 |
| DNAJC2 | regulates | gene | 0.60 |
| CHMP3 | regulates | gene | 0.60 |
| PDE4C | regulates | gene | 0.60 |
| BAG1 | regulates | gene | 0.60 |
| VTI1B | regulates | gene | 0.60 |
| EIF4G1 | regulates | gene | 0.60 |
| NOX4 | activates | gene | 0.60 |
| ACTB | activates | gene | 0.60 |
| ATG5 | activates | gene | 0.60 |
| BECN1 | activates | gene | 0.60 |
| CAT | activates | gene | 0.60 |
| CDKN1A | activates | gene | 0.60 |
| CTSD | activates | gene | 0.60 |
| CYCS | activates | gene | 0.60 |
| GAPDH | activates | gene | 0.60 |
| GLB1 | activates | gene | 0.60 |
| LAMP2 | activates | gene | 0.60 |
| MTOR | activates | gene | 0.60 |
| NBR1 | activates | gene | 0.60 |
| NFE2L2 | activates | gene | 0.60 |
| ALZHEIMER'S DISEASE | regulates | gene | 0.60 |
| CANCER | regulates | gene | 0.60 |
| APOPTOSIS | regulates | gene | 0.60 |
| MITOCHONDRIAL DYSFUNCTION | activates | gene | 0.60 |
| AND | interacts_with | gene | 0.60 |
| ERBB2 | interacts_with | gene | 0.60 |
| ROS | regulates | gene | 0.60 |
| NEURODEGENERATION | activates | entity | 0.60 |
| FERROPTOSIS | activates | gene | 0.60 |
| PARKINSON | contributes_to | gene | 0.60 |
| NADPH | activates | gene | 0.60 |
| NFKB | activates | gene | 0.60 |
| rapamycin | targets | drug | 0.60 |
| Neurodegeneration | activates | disease | 0.50 |
| benchmark_ot_ad_answer_key:NOX1 | data_in | dataset_row | 0.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||