gene

NOX1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NOX1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

107Connections
0Hypotheses
0Analyses
50Outgoing
41Incoming

Summary

NOX1 is a gene implicated in neurodegeneration research. Key relationships include: regulates, activates, interacts with. Associated with Als, Alzheimer, Atherosclerosis. Connected to 39 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolNOX1
Full NameNADPH Oxidase 1
ChromosomeXq22
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary Expressioncertain neuronal populations and glial cells within the brain
Molecular Weight65 kDa
Amino Acids564 aa
PathwaysApoptosis, Complement, Exocytosis, Mitochondrial Function
UniProt ID[Q9Y5S5](https://www.uniprot.org/uniprot/Q9Y5S5)
Ensembl IDENSG00000156508
OMIM300225
GeneCardsNOX1
Human Protein AtlasNOX1
6 transmembrane domainsPosition heme groups for electron transfer
Dehydrogenase domainContains FAD and NADPH binding sites
Associated DiseasesParkinson, Parkinson's Disease, disease, ferroptosis, neurodegeneration
Known Drugs/Compoundsrapamycin
InteractionsEGFR, EGF, OPTN, PPARGC1A, SIRT1, SQSTM1
KG Connections107 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

NOX1 Gene

gene · 980 words

Oxidative Stress in Neurodegeneration

mechanism · 3216 words

Reactive Oxygen Species (ROS) Pathway

mechanism · 3211 words

Neuroinflammation in Neurodegeneration

mechanism · 2980 words

NCF4 (Neutrophil Cytosolic Factor 4)

gene · 2227 words

renin-angiotensin-system

mechanism · 2172 words

Pathway Diagram

graph TD
    NOX1["<b>NOX1</b>"]
    Atherosclerosis{"Atherosclerosis"}
    NOX1 -->|"interacts with"| Atherosclerosis
    Dementia{"Dementia"}
    NOX1 -->|"regulates"| Dementia
    Schizophrenia{"Schizophrenia"}
    NOX1 -->|"regulates"| Schizophrenia
    Alzheimer{"Alzheimer"}
    NOX1 -->|"regulates"| Alzheimer
    Multiple_Sclerosis{"Multiple Sclerosis"}
    NOX1 -->|"regulates"| Multiple_Sclerosis
    Als{"Als"}
    NOX1 -->|"regulates"| Als
    Cancer{"Cancer"}
    NOX1 -->|"regulates"| Cancer
    Ms{"Ms"}
    NOX1 -->|"regulates"| Ms
    ERBB2["ERBB2"]
    NOX1 -->|"interacts with"| ERBB2
    EGFR["EGFR"]
    NOX1 -->|"interacts with"| EGFR
    Angiogenesis(["Angiogenesis"])
    NOX1 -->|"interacts with"| Angiogenesis
    NGF["NGF"]
    NOX1 -->|"regulates"| NGF
    EGF["EGF"]
    EGF -->|"activates"| NOX1
    NBN["NBN"]
    NBN -->|"regulates"| NOX1
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"regulates"| NOX1
    SGK3["SGK3"]
    SGK3 -->|"regulates"| NOX1
    TNF["TNF"]
    TNF -->|"regulates"| NOX1
    CANCER["CANCER"]
    CANCER -->|"regulates"| NOX1
    SLC24A2["SLC24A2"]
    SLC24A2 -->|"regulates"| NOX1
    APOPTOSIS["APOPTOSIS"]
    APOPTOSIS -->|"regulates"| NOX1
    DNAJC2["DNAJC2"]
    DNAJC2 -->|"regulates"| NOX1
    CHMP3["CHMP3"]
    CHMP3 -->|"regulates"| NOX1
    PDE4C["PDE4C"]
    PDE4C -->|"regulates"| NOX1
    BAG1["BAG1"]
    BAG1 -->|"regulates"| NOX1
    style NOX1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (66)

TargetRelationTypeStr
ds-83b31ef18d49provides_data_fordataset1.00
FERROPTOSISactivatesentity0.88
FERRITINOPHAGYassociated_withentity0.85
ROSactivatesgene0.70
Atherosclerosisinteracts_withdisease0.65

Incoming (41)

SourceRelationTypeStr
ds-83b31ef18d49data_indataset1.00
EGFactivatesgene0.60
NBNregulatesgene0.60
SGK3regulatesgene0.60
TNFregulatesgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found