gene

GALNT3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GALNT3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

60Connections
0Hypotheses
0Analyses
37Outgoing
23Incoming

Summary

Enzyme catalyzing mucin-type O-glycosylation, involved in calcium homeostasis and tumoral calcinosis

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🧬 Gene Info
Gene SymbolGALNT3
Full NamePolypeptide N-acetylgalactosaminyltransferase 3
Functionis a type II transmembrane protein localized to the Golgi apparatus, consistent with other members of the GALNT family.
Primary Expressionvarious tissues including brain, kidney, and pituitary
Subcellular Localizationthe Golgi apparatus, consistent with other members of the GALNT family. The protein consists of several distinct domains
Amino Acids10 aa
PathwaysApoptosis, Complement, Exocytosis, Mitochondrial Function
GeneCardsGALNT3
Human Protein AtlasGALNT3
TissueExpression Level
KidneyHigh
BoneModerate
BrainLow-Moderate
PituitaryModerate
Salivary glandModerate
Associated DiseasesAlzheimer's disease
InteractionsAGO2, Rb, APOPTOSIS, Ras, MIRNAS, AMPK
KG Connections60 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

GALNT3 — Polypeptide N-acetylgalactosaminyltransferase 3

gene · 1644 words

PDE4C — Phosphodiesterase 4C

gene · 1222 words

Genes

index · 271 words

Pathway Diagram

graph TD
    GALNT3["<b>GALNT3</b>"]
    Dementia{"Dementia"}
    GALNT3 -->|"regulates"| Dementia
    Schizophrenia{"Schizophrenia"}
    GALNT3 -->|"regulates"| Schizophrenia
    Alzheimer{"Alzheimer"}
    GALNT3 -->|"regulates"| Alzheimer
    Multiple_Sclerosis{"Multiple Sclerosis"}
    GALNT3 -->|"regulates"| Multiple_Sclerosis
    Als{"Als"}
    GALNT3 -->|"regulates"| Als
    Cancer{"Cancer"}
    GALNT3 -->|"regulates"| Cancer
    Ms{"Ms"}
    GALNT3 -->|"regulates"| Ms
    IREB2["IREB2"]
    GALNT3 -->|"regulates"| IREB2
    COMPLEMENT["COMPLEMENT"]
    GALNT3 -->|"regulates"| COMPLEMENT
    Apoptosis(["Apoptosis"])
    GALNT3 -->|"regulates"| Apoptosis
    Exocytosis(["Exocytosis"])
    GALNT3 -->|"regulates"| Exocytosis
    Mitochondrial_Function(["Mitochondrial Function"])
    GALNT3 -->|"regulates"| Mitochondrial_Function
    NBN["NBN"]
    NBN -->|"regulates"| GALNT3
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"regulates"| GALNT3
    SGK3["SGK3"]
    SGK3 -->|"regulates"| GALNT3
    TNF["TNF"]
    TNF -->|"associated with"| GALNT3
    CANCER["CANCER"]
    CANCER -->|"regulates"| GALNT3
    SLC24A2["SLC24A2"]
    SLC24A2 -->|"regulates"| GALNT3
    APOPTOSIS["APOPTOSIS"]
    APOPTOSIS -->|"regulates"| GALNT3
    DNAJC2["DNAJC2"]
    DNAJC2 -->|"associated with"| GALNT3
    CHMP3["CHMP3"]
    CHMP3 -->|"regulates"| GALNT3
    PDE4C["PDE4C"]
    PDE4C -->|"regulates"| GALNT3
    BAG1["BAG1"]
    BAG1 -->|"associated with"| GALNT3
    VTI1B["VTI1B"]
    VTI1B -->|"regulates"| GALNT3
    style GALNT3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (37)

TargetRelationTypeStr
Dementiaregulatesdisease0.65
Schizophreniaregulatesdisease0.65
Alzheimerregulatesdisease0.65
Multiple Sclerosisregulatesdisease0.65
Alsregulatesdisease0.65

Incoming (23)

SourceRelationTypeStr
NBNregulatesgene0.60
SGK3regulatesgene0.60
TNFassociated_withgene0.60
SLC24A2regulatesgene0.60
DNAJC2associated_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found