Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about GALNT3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Enzyme catalyzing mucin-type O-glycosylation, involved in calcium homeostasis and tumoral calcinosis
| Gene Symbol | GALNT3 |
| Full Name | Polypeptide N-acetylgalactosaminyltransferase 3 |
| Function | is a type II transmembrane protein localized to the Golgi apparatus, consistent with other members of the GALNT family. |
| Primary Expression | various tissues including brain, kidney, and pituitary |
| Subcellular Localization | the Golgi apparatus, consistent with other members of the GALNT family. The protein consists of several distinct domains |
| Amino Acids | 10 aa |
| Pathways | Apoptosis, Complement, Exocytosis, Mitochondrial Function |
| GeneCards | GALNT3 |
| Human Protein Atlas | GALNT3 |
| Tissue | Expression Level |
| Kidney | High |
| Bone | Moderate |
| Brain | Low-Moderate |
| Pituitary | Moderate |
| Salivary gland | Moderate |
| Associated Diseases | Alzheimer's disease |
| Interactions | AGO2, Rb, APOPTOSIS, Ras, MIRNAS, AMPK |
| KG Connections | 60 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
GALNT3["<b>GALNT3</b>"]
Dementia{"Dementia"}
GALNT3 -->|"regulates"| Dementia
Schizophrenia{"Schizophrenia"}
GALNT3 -->|"regulates"| Schizophrenia
Alzheimer{"Alzheimer"}
GALNT3 -->|"regulates"| Alzheimer
Multiple_Sclerosis{"Multiple Sclerosis"}
GALNT3 -->|"regulates"| Multiple_Sclerosis
Als{"Als"}
GALNT3 -->|"regulates"| Als
Cancer{"Cancer"}
GALNT3 -->|"regulates"| Cancer
Ms{"Ms"}
GALNT3 -->|"regulates"| Ms
IREB2["IREB2"]
GALNT3 -->|"regulates"| IREB2
COMPLEMENT["COMPLEMENT"]
GALNT3 -->|"regulates"| COMPLEMENT
Apoptosis(["Apoptosis"])
GALNT3 -->|"regulates"| Apoptosis
Exocytosis(["Exocytosis"])
GALNT3 -->|"regulates"| Exocytosis
Mitochondrial_Function(["Mitochondrial Function"])
GALNT3 -->|"regulates"| Mitochondrial_Function
NBN["NBN"]
NBN -->|"regulates"| GALNT3
ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
ALZHEIMER_S_DISEASE -->|"regulates"| GALNT3
SGK3["SGK3"]
SGK3 -->|"regulates"| GALNT3
TNF["TNF"]
TNF -->|"associated with"| GALNT3
CANCER["CANCER"]
CANCER -->|"regulates"| GALNT3
SLC24A2["SLC24A2"]
SLC24A2 -->|"regulates"| GALNT3
APOPTOSIS["APOPTOSIS"]
APOPTOSIS -->|"regulates"| GALNT3
DNAJC2["DNAJC2"]
DNAJC2 -->|"associated with"| GALNT3
CHMP3["CHMP3"]
CHMP3 -->|"regulates"| GALNT3
PDE4C["PDE4C"]
PDE4C -->|"regulates"| GALNT3
BAG1["BAG1"]
BAG1 -->|"associated with"| GALNT3
VTI1B["VTI1B"]
VTI1B -->|"regulates"| GALNT3
style GALNT3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Dementia | regulates | disease | 0.65 |
| Schizophrenia | regulates | disease | 0.65 |
| Alzheimer | regulates | disease | 0.65 |
| Multiple Sclerosis | regulates | disease | 0.65 |
| Als | regulates | disease | 0.65 |
| Cancer | regulates | disease | 0.65 |
| Ms | regulates | disease | 0.65 |
| Als | expressed_in | disease | 0.65 |
| Cancer | expressed_in | disease | 0.65 |
| Tumor | expressed_in | disease | 0.65 |
| ALS | expressed_in | disease | 0.65 |
| Cancer | inhibits | disease | 0.65 |
| IREB2 | regulates | gene | 0.60 |
| Rb | expressed_in | protein | 0.60 |
| AGO2 | inhibits | gene | 0.60 |
| Rb | inhibits | protein | 0.60 |
| COMPLEMENT | regulates | gene | 0.60 |
| Apoptosis | regulates | pathway | 0.60 |
| Exocytosis | regulates | pathway | 0.60 |
| Mitochondrial Function | regulates | pathway | 0.60 |
| Complement | regulates | pathway | 0.60 |
| Dna Methylation | expressed_in | pathway | 0.60 |
| Epigenetic | expressed_in | pathway | 0.60 |
| CANCER | expressed_in | gene | 0.60 |
| DNA | expressed_in | gene | 0.60 |
| Ras | expressed_in | protein | 0.60 |
| APOPTOSIS | inhibits | gene | 0.60 |
| Ras | inhibits | protein | 0.60 |
| MIRNAS | activates | gene | 0.60 |
| AMPK | activates | gene | 0.60 |
| Ampk Signaling | activates | pathway | 0.60 |
| Macrophage | activates | cell_type | 0.60 |
| App | activates | protein | 0.60 |
| cancer | expressed_in | disease | 0.50 |
| ST6GAL1 | expressed_in | concept | 0.50 |
| ST3GAL2 | expressed_in | concept | 0.50 |
| TUMOR | expressed_in | disease | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| NBN | regulates | gene | 0.60 |
| SGK3 | regulates | gene | 0.60 |
| TNF | associated_with | gene | 0.60 |
| SLC24A2 | regulates | gene | 0.60 |
| DNAJC2 | associated_with | gene | 0.60 |
| CHMP3 | regulates | gene | 0.60 |
| PDE4C | regulates | gene | 0.60 |
| BAG1 | associated_with | gene | 0.60 |
| VTI1B | regulates | gene | 0.60 |
| EIF4G1 | regulates | gene | 0.60 |
| NOX1 | regulates | gene | 0.60 |
| NGF | regulates | gene | 0.60 |
| DISC1 | associated_with | gene | 0.60 |
| ST6GAL1 | expressed_in | gene | 0.60 |
| ST3GAL2 | expressed_in | gene | 0.60 |
| ALZHEIMER'S DISEASE | regulates | gene | 0.60 |
| CANCER | regulates | gene | 0.60 |
| APOPTOSIS | regulates | gene | 0.60 |
| DNA | expressed_in | gene | 0.60 |
| GENES | expressed_in | gene | 0.60 |
| AND | expressed_in | gene | 0.60 |
| RNA | inhibits | gene | 0.60 |
| ROS | activates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||