Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SGK3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Comprehensive gene page for SGK3, a serine/threonine kinase involved in PI3K/AKT/mTOR signaling and autophagy regulation relevant to neurodegenerative diseases.
| Gene Symbol | SGK3 |
| Full Name | Serum/Glucocorticoid Regulated Kinase 3 |
| Chromosome | 8q12.3 |
| Protein Type | Kinase |
| Function | The kinase is activated by PDK1-mediated phosphorylation at Thr320, a site conserved across SGK family members [4]. |
| Subcellular Localization | distinguishes SGK3 from other SGK family members and is particularly relevant to [neurodegenerative disease mechanisms]( |
| Amino Acids | 644 aa |
| Exons | 14 |
| Pathways | PI3K, mTOR pathway, pi3k, mTOR |
| Ensembl ID | ENSG00000115297 |
| GeneCards | SGK3 |
| Human Protein Atlas | SGK3 |
| NDRG2 | A differentiation-related protein involved in neurite outgrowth |
| FOXO transcription factors | Regulates neuronal survival and stress responses |
| Tau protein | SGK3 can phosphorylate tau at multiple sites relevant to Alzheimer's disease pathology [5] |
| Associated Diseases | neurodegeneration |
| KG Connections | 29 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
SGK3["<b>SGK3</b>"]
Dementia{"Dementia"}
SGK3 -->|"regulates"| Dementia
Schizophrenia{"Schizophrenia"}
SGK3 -->|"regulates"| Schizophrenia
Alzheimer{"Alzheimer"}
SGK3 -->|"regulates"| Alzheimer
Multiple_Sclerosis{"Multiple Sclerosis"}
SGK3 -->|"regulates"| Multiple_Sclerosis
Als{"Als"}
SGK3 -->|"regulates"| Als
Cancer{"Cancer"}
SGK3 -->|"regulates"| Cancer
Ms{"Ms"}
SGK3 -->|"regulates"| Ms
TNF["TNF"]
SGK3 -->|"regulates"| TNF
CANCER["CANCER"]
SGK3 -->|"regulates"| CANCER
SLC24A2["SLC24A2"]
SGK3 -->|"regulates"| SLC24A2
APOPTOSIS["APOPTOSIS"]
SGK3 -->|"regulates"| APOPTOSIS
DNAJC2["DNAJC2"]
SGK3 -->|"regulates"| DNAJC2
NBN["NBN"]
NBN -->|"regulates"| SGK3
ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
ALZHEIMER_S_DISEASE -->|"regulates"| SGK3
style SGK3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Dementia | regulates | disease | 0.65 |
| Schizophrenia | regulates | disease | 0.65 |
| Alzheimer | regulates | disease | 0.65 |
| Multiple Sclerosis | regulates | disease | 0.65 |
| Als | regulates | disease | 0.65 |
| Cancer | regulates | disease | 0.65 |
| Ms | regulates | disease | 0.65 |
| TNF | regulates | gene | 0.60 |
| SLC24A2 | regulates | gene | 0.60 |
| DNAJC2 | regulates | gene | 0.60 |
| CHMP3 | regulates | gene | 0.60 |
| PDE4C | regulates | gene | 0.60 |
| BAG1 | regulates | gene | 0.60 |
| VTI1B | regulates | gene | 0.60 |
| EIF4G1 | regulates | gene | 0.60 |
| NOX1 | regulates | gene | 0.60 |
| NGF | regulates | gene | 0.60 |
| DISC1 | regulates | gene | 0.60 |
| GALNT3 | regulates | gene | 0.60 |
| IREB2 | regulates | gene | 0.60 |
| CANCER | regulates | gene | 0.60 |
| APOPTOSIS | regulates | gene | 0.60 |
| COMPLEMENT | regulates | gene | 0.60 |
| Apoptosis | regulates | pathway | 0.60 |
| Exocytosis | regulates | pathway | 0.60 |
| Mitochondrial Function | regulates | pathway | 0.60 |
| Complement | regulates | pathway | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| NBN | regulates | gene | 0.60 |
| ALZHEIMER'S DISEASE | regulates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||