concept

SMS2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SMS2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

75Connections

0Hypotheses

0Analyses

50Outgoing

18Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	SMS2
Related Diseases	Als, Alzheimer, ALS, Encephalitis, Meningitis
Related Pathways	Sphingomyelin Biosynthesis, Cholesterol, Apoptosis

Wiki Pages (1)

Knowledge base pages for this entity

Sphingolipid Signaling Pathway in Neurodegeneration

mechanism · 2890 words

→

Pathway Diagram

graph TD
    SMS2["SMS2"]
    SMS2 -->|"catalyzes"| Ceramide_Phosphoethanolamine["Ceramide Phosphoethanolamine"]
    SMS2 -->|"catalyzes"| Sphingomyelin["Sphingomyelin"]
    SMS2 -->|"involved_in"| Sphingomyelin_Biosynthesis["Sphingomyelin Biosynthesis"]
    SMS2 -->|"inhibits"| Als["Als"]
    SMS2 -->|"inhibits"| Alzheimer["Alzheimer"]
    SMS2 -->|"inhibits"| ALS["ALS"]
    AMYLOID["AMYLOID"] -->|"inhibits"| SMS2
    ALZHEIMER["ALZHEIMER"] -->|"inhibits"| SMS2
    APOPTOSIS["APOPTOSIS"] -->|"expressed in"| SMS2
    RNA["RNA"] -->|"inhibits"| SMS2
    IL_1["IL-1"] -->|"inhibits"| SMS2
    AND["AND"] -->|"activates"| SMS2

Outgoing (57)

Target	Relation	Type	Str
Sphingomyelin Biosynthesis	involved_in	pathway	0.90
oligodendrocytes	expressed_in	cell_type	0.90
Als	inhibits	disease	0.65
Alzheimer	inhibits	disease	0.65
Als	expressed_in	disease	0.65
Als	activates	disease	0.65
ALS	inhibits	disease	0.65
ALS	expressed_in	disease	0.65
ALS	activates	disease	0.65
Encephalitis	inhibits	disease	0.65
Meningitis	inhibits	disease	0.65
Cholesterol	inhibits	pathway	0.60
Neuron	inhibits	cell_type	0.60
Neuron	activates	cell_type	0.60
Apoptosis	expressed_in	pathway	0.60
T Cell	inhibits	cell_type	0.60
Fibroblast	associated_with	cell_type	0.60
IL-6	inhibits	gene	0.60
CYTOKINES	associated_with	gene	0.60
Oxidative Stress	expressed_in	pathway	0.60
Nf-Κb	inhibits	pathway	0.60
Er Stress	biomarker_for	pathway	0.60
Epithelial	expressed_in	cell_type	0.60
T Cell	activates	cell_type	0.60
Lipid Metabolism	regulates	pathway	0.60
Apoptosis	activates	pathway	0.60
ALZHEIMER'S DISEASE	inhibits	gene	0.60
AMYLOID	inhibits	gene	0.60
Amyloid	inhibits	pathway	0.60
Sphingolipid	regulates	pathway	0.60
Actin	expressed_in	protein	0.60
Aβ	inhibits	protein	0.60
Interleukin	inhibits	protein	0.60
RNA	inhibits	gene	0.60
IL-1	inhibits	gene	0.60
Er Stress	inhibits	pathway	0.60
Cytokine	associated_with	protein	0.60
Raf	inhibits	protein	0.60
Rb	inhibits	protein	0.60
Il-1	inhibits	protein	0.60
apoptosis pathway	participates_in	pathway	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
oxidative stress response	participates_in	pathway	0.60
NF-kB signaling	participates_in	pathway	0.60
hippocampus	expressed_in	brain_region	0.60
ER stress	biomarker_for	process	0.60
Hippocampus	expressed_in	brain_region	0.55
Cortex	expressed_in	brain_region	0.55
Ca1	expressed_in	brain_region	0.55
Dentate Gyrus	expressed_in	brain_region	0.55

Incoming (18)

Source	Relation	Type	Str
AMYLOID	inhibits	gene	0.60
ALZHEIMER	inhibits	gene	0.60
APOPTOSIS	expressed_in	gene	0.60
RNA	inhibits	gene	0.60
IL-1	inhibits	gene	0.60
RNA	biomarker_for	gene	0.60
APOPTOSIS	activates	gene	0.60
AND	activates	gene	0.60
HIPPO	activates	gene	0.60
AND	expressed_in	gene	0.60
AND	inhibits	gene	0.60
CYTOKINES	associated_with	gene	0.60
NF-ΚB	inhibits	gene	0.60
OXIDATIVE STRESS	expressed_in	gene	0.60
IL-6	inhibits	gene	0.60
AND	regulates	gene	0.60
SGMS1	inhibits	gene	0.55
SGMS2	inhibits	gene	0.55

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found