Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SPARC: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | SPARC |
| Function | SPARC (Secreted Protein Acidic and Rich in Cysteine), also known as osteonectin, is a matricellular protein that modulates cell-matrix interactions and tissue remodeling. |
| Molecular Weight | 43 kDa |
| Pathways | Synaptic Plasticity |
| GeneCards | SPARC |
| Human Protein Atlas | SPARC |
| Associated Diseases | Alzheimer, disease, neurodegeneration |
| Interactions | IRISIN, IL-8, ALZHEIMER, BDNF, FGF21 |
| KG Connections | 36 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
SPARC["<b>SPARC</b>"]
STING(["STING"])
SPARC -->|"co_discussed"| STING
NF__B["NF-kappaB"]
SPARC -->|"activates"| NF__B
Differentiation["Differentiation"]
SPARC -->|"activates"| Differentiation
IRISIN(["IRISIN"])
SPARC -->|"activates"| IRISIN
IL_8(["IL-8"])
SPARC -->|"activates"| IL_8
Synaptic_Plasticity["Synaptic Plasticity"]
SPARC -->|"activates"| Synaptic_Plasticity
ALZHEIMER(["ALZHEIMER"])
ALZHEIMER -->|"activates"| SPARC
BDNF(["BDNF"])
BDNF -->|"co_discussed"| SPARC
FGF21(["FGF21"])
FGF21 -->|"co_discussed"| SPARC
style SPARC fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#4fc3f7| Target | Relation | Type | Str |
|---|---|---|---|
| neurodegeneration | associated_with | disease | 0.60 |
| Alzheimer | associated_with | disease | 0.60 |
| STING | co_discussed | gene | 0.50 |
| NF-κB | activates | concept | 0.50 |
| IRISIN | activates | protein | 0.50 |
| IL-8 | activates | protein | 0.50 |
| Synaptic Plasticity | activates | pathway | 0.50 |
| Neuroprotection | activates | process | 0.50 |
| IGF-1 | activates | concept | 0.50 |
| VEGFB | associated_with | protein | 0.50 |
| VEGFA | associated_with | protein | 0.50 |
| disease | associated_with | disease | 0.50 |
| ACHE | associated_with | concept | 0.50 |
| ENDOTHELIAL | associated_with | concept | 0.50 |
| Proteins | associated_with | protein | 0.50 |
| TFAM | co_expressed_with | gene | 0.50 |
| TNF | co_expressed_with | gene | 0.50 |
| SPP1 | co_expressed_with | gene | 0.50 |
| SST | co_expressed_with | gene | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| NF-κB | upregulates | pathway | 0.80 |
| ALZHEIMER | activates | gene | 0.50 |
| BDNF | co_discussed | gene | 0.50 |
| FGF21 | co_discussed | gene | 0.50 |
| GENES | co_discussed | gene | 0.50 |
| HEPSIN | co_discussed | protein | 0.50 |
| IRISIN | co_discussed | protein | 0.50 |
| SCRIB | co_discussed | gene | 0.50 |
| mTOR | activates | entity | 0.50 |
| BDNF | activates | gene | 0.50 |
| FGF21 | activates | gene | 0.50 |
| PINK1 | co_expressed_with | gene | 0.50 |
| PTEN | co_expressed_with | gene | 0.50 |
| NPTX2 | co_expressed_with | protein | 0.50 |
| RAS | co_expressed_with | gene | 0.50 |
| BDNF | co_expressed_with | gene | 0.50 |
| FGF21 | co_expressed_with | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||