protein

SPARC

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SPARC: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

37Connections

0Hypotheses

1Analyses

20Outgoing

17Incoming

0Experiments

1Debates

Summary

Page for SPARC Protein

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🔬 Protein Info

Gene Symbol	SPARC
Function	SPARC (Secreted Protein Acidic and Rich in Cysteine), also known as osteonectin, is a matricellular protein that modulates cell-matrix interactions and tissue remodeling.
Molecular Weight	43 kDa
Pathways	Synaptic Plasticity
GeneCards	SPARC
Human Protein Atlas	SPARC
Associated Diseases	Alzheimer, disease, neurodegeneration
Interactions	ALZHEIMER, BDNF, FGF21, IL-8, IRISIN
KG Connections	37 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

SPARC Protein

protein · 611 words

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Pathway Diagram

graph TD
    SPARC["SPARC"]
    STING(["STING"])
    SPARC -->|"co_discussed"| STING
    NF__B["NF-kappaB"]
    SPARC -->|"activates"| NF__B
    Differentiation["Differentiation"]
    SPARC -->|"activates"| Differentiation
    IRISIN(["IRISIN"])
    SPARC -->|"activates"| IRISIN
    IL_8(["IL-8"])
    SPARC -->|"activates"| IL_8
    Synaptic_Plasticity["Synaptic Plasticity"]
    SPARC -->|"activates"| Synaptic_Plasticity
    ALZHEIMER(["ALZHEIMER"])
    ALZHEIMER -->|"activates"| SPARC
    BDNF(["BDNF"])
    BDNF -->|"co_discussed"| SPARC
    FGF21(["FGF21"])
    FGF21 -->|"co_discussed"| SPARC
    style SPARC fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#4fc3f7

Outgoing (20)

Target	Relation	Type	Str
Synaptic Remodeling	regulates	phenotype	0.70
neurodegeneration	associated_with	disease	0.60
Alzheimer	associated_with	disease	0.60
VEGFA	associated_with	protein	0.50
disease	associated_with	disease	0.50
ACHE	associated_with	concept	0.50
ENDOTHELIAL	associated_with	concept	0.50
Proteins	associated_with	protein	0.50
TFAM	co_expressed_with	gene	0.50
TNF	co_expressed_with	gene	0.50
SPP1	co_expressed_with	gene	0.50
STING	co_discussed	gene	0.50
SST	co_expressed_with	gene	0.50
VEGFB	associated_with	protein	0.50
IRISIN	activates	protein	0.50
IL-8	activates	protein	0.50
NF-κB	activates	concept	0.50
Neuroprotection	activates	process	0.50
IGF-1	activates	concept	0.50
Synaptic Plasticity	activates	pathway	0.50

Incoming (17)

Source	Relation	Type	Str
NF-κB	upregulates	pathway	0.80
BDNF	co_discussed	gene	0.50
FGF21	co_discussed	gene	0.50
GENES	co_discussed	gene	0.50
HEPSIN	co_discussed	protein	0.50
IRISIN	co_discussed	protein	0.50
SCRIB	co_discussed	gene	0.50
ALZHEIMER	activates	gene	0.50
mTOR	activates	entity	0.50
BDNF	activates	gene	0.50
FGF21	activates	gene	0.50
PINK1	co_expressed_with	gene	0.50
PTEN	co_expressed_with	gene	0.50
NPTX2	co_expressed_with	protein	0.50
RAS	co_expressed_with	gene	0.50
BDNF	co_expressed_with	gene	0.50
FGF21	co_expressed_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Gene expression changes in aging mouse brain predicting neurodegenerative vulner

neurodegeneration | 2026-04-02 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

What gene expression changes in the aging mouse brain predict neurodegenerative

closed · Rounds: 4 · Score: 0.71 · 2026-04-02

Related Research

Hypotheses and analyses mentioning SPARC in their description or question text

No additional research found