protein

HEPSIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HEPSIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

102Connections

9Hypotheses

0Analyses

50Outgoing

33Incoming

0Experiments

0Debates

Summary

Type II transmembrane serine protease with roles in APP processing, extracellular matrix remodeling, and potential implications in Alzheimer's disease and neurodegeneration.

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🔬 Protein Info

Gene Symbol	HEPSIN
Chromosome	19q13.12
Protein Type	Protease
Function	is a type II transmembrane serine protease (TTSP) that belongs to the family of trypsin-like serine proteases.
Primary Expression	various tissues, including the liver, kidney, and brain, where it plays important roles in extracellular matrix remodeling, cell growth, and signal tr
Amino Acids	18 aa
GeneCards	HEPSIN
Human Protein Atlas	HEPSIN
Associated Diseases	neurodegeneration
KG Connections	102 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Hepsin Protein

protein · 1933 words

→

Pathway Diagram

graph TD
    HEPSIN("HEPSIN")
    IL_6("IL-6")
    HEPSIN -->|"co_discussed"| IL_6
    IL_8("IL-8")
    HEPSIN -->|"co_discussed"| IL_8
    IRISIN("IRISIN")
    HEPSIN -->|"co_discussed"| IRISIN
    SCRIB["SCRIB"]
    HEPSIN -->|"co_discussed"| SCRIB
    SPARC("SPARC")
    HEPSIN -->|"co_discussed"| SPARC
    STING["STING"]
    HEPSIN -->|"co_discussed"| STING
    ALZHEIMER["ALZHEIMER"]
    ALZHEIMER -->|"co_discussed"| HEPSIN
    BDNF["BDNF"]
    BDNF -->|"co_discussed"| HEPSIN
    FGF21["FGF21"]
    FGF21 -->|"co_discussed"| HEPSIN
    GENES["GENES"]
    GENES -->|"co_discussed"| HEPSIN
    neurodegeneration["neurodegeneration"]
    HEPSIN -->|"implicated_in"| neurodegeneration

Outgoing (69)

Target	Relation	Type	Str
SCRIB	co_discussed	gene	0.50
STING	co_discussed	gene	0.50
IL-6	co_discussed	protein	0.50
IL-8	co_discussed	protein	0.50
IRISIN	co_discussed	protein	0.50
SPARC	co_discussed	protein	0.50
DDIT3	co_discussed	gene	0.40
CHOP	co_discussed	gene	0.40
DISC1	co_discussed	gene	0.40
DNM1L	co_discussed	gene	0.40
DRP1	co_discussed	protein	0.40
EIF2AK3	co_discussed	gene	0.40
PERK	co_discussed	protein	0.40
EIF2S1	co_discussed	gene	0.40
EMD	co_discussed	gene	0.40
EPAS1	co_discussed	gene	0.40
ERN1	co_discussed	gene	0.40
IRE1	co_discussed	protein	0.40
GNAL	co_discussed	gene	0.40
FUNDC1	co_discussed	gene	0.40
G3BP1	co_discussed	gene	0.40
GBA	co_discussed	gene	0.40
HIF1A	co_discussed	protein	0.40
LGALS3	co_discussed	gene	0.40
LC3	co_discussed	protein	0.40
LMNA	co_discussed	gene	0.40
MAPK8	co_discussed	gene	0.40
JNK	co_discussed	protein	0.40
MAP1LC3B	co_discussed	gene	0.40
MFN1	co_discussed	gene	0.40
DYSF	co_discussed	gene	0.40
MUL1	co_discussed	gene	0.40
NBR1	co_discussed	gene	0.40
NLRP3	co_discussed	protein	0.40
FMR1	co_discussed	gene	0.40
OPTN	co_discussed	gene	0.40
OPTINEURIN	co_discussed	protein	0.40
PARL	co_discussed	protein	0.40
PEX3	co_discussed	gene	0.40
PINK1	co_discussed	gene	0.40
PTEN	co_discussed	gene	0.40
PRKN	co_discussed	gene	0.40
PARKIN	co_discussed	gene	0.40
RB1CC1	co_discussed	gene	0.40
FIP200	co_discussed	gene	0.40
RB1	co_discussed	protein	0.40
FAM134B	co_discussed	gene	0.40
RHOT1	co_discussed	gene	0.40
MIRO1	co_discussed	protein	0.40
RIPK3	co_discussed	gene	0.40

Incoming (33)

Source	Relation	Type	Str
ALZHEIMER	co_discussed	gene	0.50
GENES	co_discussed	gene	0.50
BDNF	co_discussed	gene	0.50
FGF21	co_discussed	gene	0.50
AMPK	co_discussed	protein	0.40
ABCD3	co_discussed	gene	0.40
MYOT	co_discussed	gene	0.40
RELA	co_discussed	gene	0.40
ATM	co_discussed	protein	0.40
BCL2	co_discussed	gene	0.40
BCL2L11	co_discussed	gene	0.40
BCL2L13	co_discussed	gene	0.40
BECN1	co_discussed	gene	0.40
BNIP3	co_discussed	gene	0.40
BNIP3L	co_discussed	protein	0.40
CALCOCO2	co_discussed	gene	0.40
NDP52	co_discussed	gene	0.40
ACTIN	co_discussed	protein	0.40
CATALASE	co_discussed	protein	0.40
CELL CYCLE	co_discussed	pathway	0.40
AMBRA1	co_discussed	protein	0.40
COPD	co_discussed	disease	0.40
UBIQUITIN	co_discussed	protein	0.40
CANX	co_discussed	gene	0.40
CAT	co_discussed	gene	0.40
CTSD	co_discussed	gene	0.40
APOPTOSIS	co_discussed	process	0.40
AUTOPHAGY	co_discussed	process	0.40
ALZHEIMER DISEASE	co_discussed	gene	0.40
ALS	co_discussed	disease	0.40
LATE	co_discussed	disease	0.40
ATG	co_discussed	gene	0.40
BIM	co_discussed	protein	0.40

Targeting Hypotheses (9)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Lysosomal Cathepsin-Dependent Tau Clearance	0.767	neurodegeneration	Does the cancer-cystatin-C-TREM2 pathway
PD-Associated GWAS Variants in CTSO and CTSF Genes Create a	0.743	neurodegeneration	-
Dual Calpain/Cathepsin B Inhibition as Primary Neuroprotecti	0.644	neurodegeneration	Why does autophagy inhibition improve ne
Selective cathepsin B inhibition prevents cathepsin leakage-	0.620	neuroscience	Lysosomal dysfunction and cathepsin leak
Limited Calcium Release Without Sufficient Cathepsin Efflux	0.580	neurodegeneration	How does controlled lysosomal membrane p

Hsp70-based therapy to prevent lysosomal membrane permeabili	0.570	neuroscience	Lysosomal dysfunction and cathepsin leak
Cathepsin D Replacement to Overcome Lysosomal Protease Defic	0.434	proteomics	Quantitative proteomics of the aging syn
Cathepsin-Dependent Processing of Pro-Drug Enzymes	0.400	neurodegeneration	How does controlled lysosomal membrane p
Cathepsin D Enhancement for Tau Degradation	0.000	-	Tau propagation mechanisms and therapeut

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (7)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810]	["Chen Kai", "Li Fuyao", "Zhang Shuwen",	Journal of neuroinflammation	2025
Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810]	["Chen Kai", "Li Fuyao", "Zhang Shuwen",	Journal of neuroinflammation	2025
Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554]	Marogianni C, Sokratous M, Dardiotis E,	International journal of molec	2020
Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554]	Marogianni C, Sokratous M, Dardiotis E,	International journal of molec	2020
Multiple Sclerosis Pathology. [PMID:29358320]	Lassmann H	Cold Spring Harbor perspective	2018
Tau, neurodegeneration and Alzheimer's disease. [PMID:21214513]	Unknown	Curr Alzheimer Res	2010
TNF-alpha signaling in glaucomatous neurodegeneration. [PMID:18929124]	Unknown	Prog Brain Res	2008

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning HEPSIN in their description or question text

Hsp70-based therapy to prevent lysosomal membrane permeabilization and cathepsin

Score: 0.570 · neuroscience · 2026-04-22

## Mechanistic Overview Hsp70-based therapy to prevent lysosomal membrane permeabilization and cathepsin release in AD s

Cathepsin D Replacement to Overcome Lysosomal Protease Deficiency

Score: 0.434 · proteomics · 2026-04-25

Cathepsin D Replacement to Overcome Lysosomal Protease Deficiency

Cathepsin-Dependent Processing of Pro-Drug Enzymes

Score: 0.400 · neurodegeneration · 2026-04-21

## Mechanistic Overview Cathepsin-Dependent Processing of Pro-Drug Enzymes starts from the claim that modulating CTSD, U

Cathepsin D Enhancement for Tau Degradation

Score: 0.000 · unknown disease · 2026-04-28

Recombinant pro-cathepsin D enhances pathological protein degradation in lysosomes. Targeted delivery of stabilized cath