gene

SCRIB

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SCRIB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

37Connections

0Hypotheses

5Analyses

16Outgoing

21Incoming

Summary

SCRIB (Scribble) is a scaffold protein critical for cell polarity, neuronal development, and synaptic function. It is a tumor suppressor implicated in neurodevelopmental disorders and Alzheimer's disease.

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🧬 Gene Info

Gene Symbol	SCRIB
Full Name	Scribble Planar Cell Polarity Protein
Aliases	Scribbled, SCRIB1
Chromosome	8q24.3
Function	encodes a protein of 1,757 amino acids with a molecular weight of approximately 220 kDa.
Primary Expression	Brain (cortex, hippocampus, cerebellum), epithelial tissues
Molecular Weight	220 kDa
Amino Acids	1757 aa
Exons	34
Pathways	Autophagy, Inflammasome, Phagocytosis
UniProt ID	Q14160
NCBI Gene ID	23513
Ensembl ID	ENSG00000103067
OMIM	607584
GeneCards	SCRIB
Human Protein Atlas	SCRIB
Associated Diseases	Alzheimer's disease, Parkinson's disease
Interactions	NLRP3, MICROGLIA, PARKINSON, AUTOPHAGY, ROS, NEURON
KG Connections	37 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: SCRIB — AlphaFold Q14160 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    SCRIB["<b>SCRIB</b>"]
    SPARC(["SPARC"])
    SCRIB -->|"co_discussed"| SPARC
    STING(["STING"])
    SCRIB -->|"co_discussed"| STING
    WAS(["WAS"])
    SCRIB -->|"co_discussed"| WAS
    neurodegeneration["neurodegeneration"]
    SCRIB -->|"implicated_in"| neurodegeneration
    ALZHEIMER(["ALZHEIMER"])
    ALZHEIMER -->|"co_discussed"| SCRIB
    AMYLOID(["AMYLOID"])
    AMYLOID -->|"co_discussed"| SCRIB
    GENES(["GENES"])
    GENES -->|"co_discussed"| SCRIB
    MICRORNAS(["MICRORNAS"])
    MICRORNAS -->|"co_discussed"| SCRIB
    style SCRIB fill:#1a3a4a,stroke:#ce93d8,stroke-width:3px,color:#ce93d8

Outgoing (16)

Target	Relation	Type	Str
Parkinson	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
NLRP3	activates	gene	0.60
MICROGLIA	activates	gene	0.60
PARKINSON	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
ROS	activates	gene	0.60
Autophagy	activates	pathway	0.60
Inflammasome	activates	pathway	0.60
Phagocytosis	activates	pathway	0.60
Microglia	activates	cell_type	0.60
Neuron	activates	cell_type	0.60
STING	co_discussed	gene	0.50
SPARC	co_discussed	protein	0.50
WAS	co_discussed	protein	0.50
MICROGLIA	co_discussed	cell_type	0.40

Incoming (21)

Source	Relation	Type	Str
NEURON	activates	gene	0.60
BAK1	co_discussed	gene	0.50
BAX	co_discussed	gene	0.50
BID	co_discussed	gene	0.50
MTOR	co_discussed	gene	0.50
BDNF	co_discussed	gene	0.50
FGF21	co_discussed	gene	0.50
HEPSIN	co_discussed	protein	0.50
APC	co_discussed	gene	0.50
APP	co_discussed	gene	0.50
GFAP	co_discussed	gene	0.50
MIRO1	co_discussed	protein	0.50
PARKIN	co_discussed	gene	0.50
ALZHEIMER	co_discussed	gene	0.50
AMYLOID	co_discussed	gene	0.50
GENES	co_discussed	gene	0.50
MICRORNAS	co_discussed	gene	0.50
IRISIN	co_discussed	protein	0.50
CANCER	co_discussed	gene	0.50
HUNTINGTON	co_discussed	gene	0.50
PARKINSON	co_discussed	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (5)

Scientific analyses that reference this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

SCRIB

Understanding Entity Pages

Summary

Wiki Pages (4)

SCRIB Gene

Hepsin Protein

FYCO1 Protein — FYVE and Coiled-Coil Domain Containing 1

Genes

Pathway Diagram

Outgoing (16)

Incoming (21)

Targeting Hypotheses (0)

Mentioning Analyses (5)

What molecular mechanisms determine whether reactive astrocytes adopt neurotoxic

How do P/Q channel deficits paradoxically increase thalamic excitability despite

How does PIKFYVE inhibition activate unconventional protein clearance via exocyt

What neural circuits encode and maintain multi-generational migratory route memo

What causes IBA1 low/negative microglia in liver disease and how does this affec

Related Papers (0)