SciDEX — Pulmonary Fibrosis

graph TD
    Pulmonary_Fibrosis["<b>Pulmonary Fibrosis</b>"]
    Fibrosis{"Fibrosis"}
    Pulmonary_Fibrosis -->|"activates"| Fibrosis
    Inflammation{"Inflammation"}
    Pulmonary_Fibrosis -->|"therapeutic_target"| Inflammation
    Autophagy["Autophagy"]
    Pulmonary_Fibrosis -->|"activates"| Autophagy
    Apoptosis["Apoptosis"]
    Pulmonary_Fibrosis -.->|"inhibits"| Apoptosis
    INFLAMMATION(["INFLAMMATION"])
    INFLAMMATION -->|"therapeutic_target"| Pulmonary_Fibrosis
    CANCER(["CANCER"])
    CANCER -->|"therapeutic_target"| Pulmonary_Fibrosis
    Cancer{"Cancer"}
    Cancer -->|"therapeutic_target"| Pulmonary_Fibrosis
    style Pulmonary_Fibrosis fill:#1a3a4a,stroke:#ef5350,stroke-width:3px,color:#e0e0e0

Outgoing (80)

Target	Relation	Type	Str
Fibrosis	activates	disease	1.00
Fibrosis	therapeutic_target	disease	1.00
Inflammation	therapeutic_target	disease	0.95
Fibrosis	inhibits	disease	0.75
Autophagy	activates	pathway	0.70
Apoptosis	inhibits	pathway	0.70
Apoptosis	therapeutic_target	pathway	0.70
Inflammation	contributes_to	disease	0.65
Lung Cancer	therapeutic_target	disease	0.65
Inflammation	inhibits	disease	0.65
Mtor	therapeutic_target	pathway	0.60
Mtor	associated_with	pathway	0.60
Autophagy	associated_with	pathway	0.60
Autophagy	regulates	pathway	0.60
Ubiquitin-Proteasome	regulates	pathway	0.60
Er Stress	regulates	pathway	0.60
Apoptosis	regulates	pathway	0.60
Unfolded Protein Response	regulates	pathway	0.60
Telomere	regulates	pathway	0.60
Mitophagy	regulates	pathway	0.60
Proteasome	regulates	pathway	0.60
Notch	therapeutic_target	pathway	0.60
Wnt	therapeutic_target	pathway	0.60
Epigenetic	therapeutic_target	pathway	0.60
Pi3K/Akt	activates	pathway	0.60
Mitophagy	therapeutic_target	pathway	0.60
Stem Cell	therapeutic_target	pathway	0.60
Toll-Like Receptor	regulates	pathway	0.60
Microbiota	inhibits	pathway	0.60
Nf-Κb	inhibits	pathway	0.60
Immune Response	contributes_to	pathway	0.60
Oxidative Stress	activates	pathway	0.60
Mitophagy	activates	pathway	0.60
Dna Repair	activates	pathway	0.60
Ferroptosis	activates	pathway	0.60
Senescence	inhibits	pathway	0.60
Epigenetic	activates	pathway	0.60
Senescence	therapeutic_target	pathway	0.60
Differentiation	regulates	pathway	0.60
Epithelial-Mesenchymal Transition	regulates	pathway	0.60
Ubiquitin-Proteasome	associated_with	pathway	0.60
Tgf-Β	regulates	pathway	0.60
Proteasome	associated_with	pathway	0.60
Differentiation	activates	pathway	0.60
Immunotherapy	treats	pathway	0.60
Immune Response	interacts_with	pathway	0.60
Immune Response	activates	pathway	0.60
Yap/Taz	activates	pathway	0.60
Fibrosis	regulates	disease	0.55
Hepatitis	therapeutic_target	disease	0.55

Incoming (227)

Source	Relation	Type	Str
INFLAMMATION	therapeutic_target	gene	1.00
CANCER	therapeutic_target	gene	0.85
Fibrosis	associated_with	disease	0.85
TGF-Β1	causes	protein	0.80
Cancer	therapeutic_target	disease	0.75
Als	therapeutic_target	disease	0.75
INFLAMMATION	contributes_to	gene	0.75
AUTOPHAGY	activates	gene	0.75
GAIN	therapeutic_target	gene	0.75
Infection	therapeutic_target	disease	0.75
APOPTOSIS	inhibits	gene	0.75
INFLAMMATION	inhibits	gene	0.75
IL-6	inhibits	gene	0.75
DNA	activates	gene	0.75
APOPTOSIS	therapeutic_target	gene	0.75
AGING	therapeutic_target	gene	0.65
MTORC1	therapeutic_target	gene	0.65
MTOR	therapeutic_target	gene	0.65
PAH	associated_with	gene	0.65
ATG	associated_with	gene	0.65
ROS	associated_with	gene	0.65
AUTOPHAGY	associated_with	gene	0.65
TNF	associated_with	gene	0.65
CFTR	associated_with	gene	0.65
TGFB1	associated_with	gene	0.65
MAP1LC3B	associated_with	gene	0.65
MTOR	associated_with	gene	0.65
Asthma	contributes_to	disease	0.65
KEAP1	activates	gene	0.65
MAP1LC3	activates	gene	0.65
LC3	activates	gene	0.65
NRF2	activates	gene	0.65
P62	activates	gene	0.65
AUTOPHAGY	regulates	gene	0.65
MITOPHAGY	regulates	gene	0.65
APOPTOSIS	regulates	gene	0.65
UBIQUITIN	regulates	gene	0.65
MITOCHONDRIAL DYSFUNCTION	regulates	gene	0.65
CREBBP	therapeutic_target	gene	0.65
FGF18	therapeutic_target	gene	0.65
CDH1	therapeutic_target	gene	0.65
BRG1	therapeutic_target	gene	0.65
NEUROD1	therapeutic_target	gene	0.65
VEGFA	therapeutic_target	gene	0.65
EP300	therapeutic_target	gene	0.65
IL10	therapeutic_target	gene	0.65
TERT	therapeutic_target	gene	0.65
SMARCA4	therapeutic_target	gene	0.65
GENES	therapeutic_target	gene	0.65
NOTCH2	therapeutic_target	gene	0.65

Associated Genes	PAH, ATG, ROS, AUTOPHAGY, TNF, CFTR, TGFB1, MAP1LC3B
KG Connections	274 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Pulmonary Fibrosis

Understanding Entity Pages

Wiki Pages (20)

Longevity and Rejuvenation Therapies Landscape

Senolytic Therapies for CBS and [PSP](/diseases/progressive-supranuclear-palsy)

TAZ (WWTR1)

TERT Gene

Cyclophosphamide

Pathway Diagram

Outgoing (80)

Incoming (227)

Targeting Hypotheses (0)

Mentioning Analyses (0)

Related Papers (0)

Pulmonary Fibrosis

Understanding Entity Pages

Wiki Pages (20)

Longevity and Rejuvenation Therapies Landscape

Senolytic Therapies for CBS and [PSP](/diseases/progressive-supranuclear-palsy)

TAZ (WWTR1)

TERT Gene

Cyclophosphamide

Senolytic Therapies for Parkinson's Disease

Section 135: Telomere Biology and Anti-Aging Interventions in CBS/PSP

Cellular Senescence Therapeutic Targeting

VAMP7 Gene

JNK/p38 MAPK Inhibitor Companies for Parkinson's Disease

ANO9 — Anoctamin 9

Presenilin-2 (PS2)

Senomorphics in Neurodegeneration

Senolytics and Senotherapeutics in Neurodegeneration

Galectin-3 Mechanism in Neurodegeneration

Galectin-3 Inhibitors for Neurodegeneration

WNT11 Gene

Galectin-3 Inhibitor Therapy

tgf-beta-modulation-therapy

Senolytic Agents for Neurodegeneration

Pathway Diagram

Outgoing (80)

Incoming (227)

Targeting Hypotheses (0)

Mentioning Analyses (0)

Related Papers (0)