Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about IRAK4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
IRAK4 is a gene implicated in neurodegeneration research. Key relationships include: activates, expressed in, implicated in. Associated with Als, Inflammation. Connected to 12 entities in the SciDEX knowledge graph.
| Gene Symbol | IRAK4 |
| Chromosome | 15q15.4 |
| Protein Family | IL-1 receptor-associated kinases |
| Protein Type | Serine/Threonine Kinase |
| Function | IRAK4 is a serine/threonine kinase essential for TLR/IL-1R signaling. |
| Molecular Weight | 52 kDa |
| Amino Acids | 460 aa |
| Pathways | NF-κB, MAPK signaling, NF-κB signaling, NF-κB pathway, NF-κB Signaling |
| UniProt ID | Q9NWZ3 |
| GeneCards | IRAK4 |
| Human Protein Atlas | IRAK4 |
| N-terminal Death Domain (DD) | Mediates interactions with MyD88 adaptor protein |
| Intermediate domain | Connects DD to kinase domain |
| Kinase Domain (KD) | Catalytic domain with serine/threonine kinase activity (active, unlike IRAK2/3) |
| Active kinase | Unlike IRAK2 and IRAK3, IRAK4 has demonstrable kinase activity |
| Associated Diseases | neurodegeneration |
| Interactions | CSF2, IL1A, IRF3, TAK1, TLR4, TRAF6 |
| KG Connections | 44 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
IRAK4["<b>IRAK4</b>"]
Als{"Als"}
IRAK4 -->|"expressed_in"| Als
Inflammation{"Inflammation"}
IRAK4 -->|"activates"| Inflammation
Cancer{"Cancer"}
IRAK4 -->|"activates"| Cancer
TAB1(["TAB1"])
IRAK4 -->|"expressed_in"| TAB1
CYTOKINES(["CYTOKINES"])
IRAK4 -->|"activates"| CYTOKINES
IL_1(["IL-1"])
IL_1 -->|"activates"| IRAK4
IL1B(["IL1B"])
IL1B -->|"activates"| IRAK4
RNA(["RNA"])
RNA -->|"activates"| IRAK4
style IRAK4 fill:#1a3a4a,stroke:#ce93d8,stroke-width:3px,color:#ce93d8| Target | Relation | Type | Str |
|---|---|---|---|
| Als | expressed_in | disease | 0.65 |
| Inflammation | activates | disease | 0.65 |
| Als | activates | disease | 0.65 |
| Cancer | activates | disease | 0.65 |
| TAB1 | expressed_in | gene | 0.60 |
| RELA | expressed_in | gene | 0.60 |
| CSF2 | activates | gene | 0.60 |
| IL1A | activates | gene | 0.60 |
| TLR4 | inhibits | gene | 0.60 |
| TRAF6 | inhibits | gene | 0.60 |
| MAPK1 | regulates | gene | 0.60 |
| CYTOKINES | activates | gene | 0.60 |
| NF-ΚB | expressed_in | gene | 0.60 |
| IL-6 | activates | gene | 0.60 |
| INFLAMMATION | activates | gene | 0.60 |
| PROINFLAMMATORY CYTOKINES | activates | gene | 0.60 |
| Nf-Κb | expressed_in | pathway | 0.60 |
| Microrna | activates | pathway | 0.60 |
| Nf-Κb | activates | pathway | 0.60 |
| Interferon Signaling | activates | pathway | 0.60 |
| Macrophage | activates | cell_type | 0.60 |
| Fibroblast | activates | cell_type | 0.60 |
| Il-1 | activates | protein | 0.60 |
| App | activates | protein | 0.60 |
| NF-kB signaling | participates_in | pathway | 0.60 |
| frontotemporal dementia | regulates | disease | 0.60 |
| MAPK signaling | participates_in | pathway | 0.60 |
| ubiquitin-proteasome | participates_in | pathway | 0.60 |
| IRF3 | activates | gene | 0.55 |
| TAK1 | activates | gene | 0.55 |
| TLR4 | activates | gene | 0.55 |
| TRAF6 | activates | gene | 0.55 |
| microglia | expressed_in | cell_type | 0.55 |
| MAX | debate_co_mention | gene | 0.45 |
| MDM2 | debate_co_mention | gene | 0.45 |
| MTOR | debate_co_mention | gene | 0.45 |
| STAT3 | debate_co_mention | gene | 0.45 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||