concept

XCT

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about XCT: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

77Connections

0Hypotheses

0Analyses

48Outgoing

23Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	XCT
Key Genes/Proteins	GPX4, FERROPTOSIS, CANCER
Related Diseases	Tumor, Cancer, ALS, Ferroptosis, Als
Related Pathways	Ferroptosis

Wiki Pages (14)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    XCT["XCT"]
    XCT -->|"regulates"| cystine["cystine"]
    XCT -->|"activates"| Tumor["Tumor"]
    XCT -->|"transports"| Cancer["Cancer"]
    XCT -->|"target for"| Ferroptosis["Ferroptosis"]
    XCT -->|"activates"| Parkinson["Parkinson"]
    XCT -->|"transports"| Als["Als"]
    NRF2["NRF2"] -->|"regulates"| XCT
    SLC7A11["SLC7A11"] -->|"encodes"| XCT
    Nrf2["Nrf2"] -->|"activates"| XCT
    AND["AND"] -->|"transports"| XCT
    LC3["LC3"] -->|"activates"| XCT

Outgoing (50)

Target	Relation	Type	Str
FERROPTOSIS	inhibits	process	0.80
oxidative stress	downregulates	process	0.80
GPX4	interacts_with	protein	0.75
Tumor	activates	disease	0.65
Cancer	transports	disease	0.65
ALS	associated_with	disease	0.65
Ferroptosis	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Als	associated_with	disease	0.65
Ferroptosis	expressed_in	disease	0.65
Parkinson	activates	disease	0.65
Als	transports	disease	0.65
FERROPTOSIS	transports	gene	0.60
CANCER	transports	gene	0.60
Ferroptosis	transports	pathway	0.60
FERROPTOSIS	therapeutic_target	gene	0.60
MTOR	activates	gene	0.60
ROS	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
NCOA4	expressed_in	gene	0.60
FERROPTOSIS	expressed_in	gene	0.60
LC3	activates	gene	0.60
NEURON	activates	gene	0.60
GPX4	expressed_in	gene	0.60
ATG5	activates	gene	0.60
HO-1	activates	gene	0.60
P62	activates	gene	0.60
BAX	activates	gene	0.60
BCL-2	activates	gene	0.60
PARKINSON	activates	gene	0.60
Oxidative Stress	activates	pathway	0.60
Autophagy	activates	pathway	0.60
Mtor	activates	pathway	0.60
Apoptosis	activates	pathway	0.60
Neuron	activates	cell_type	0.60
AND	expressed_in	gene	0.60
PARKINSON'S DISEASE	activates	gene	0.60
COX2	expressed_in	gene	0.60
SLC7A11	transports	gene	0.60
AND	transports	gene	0.60
SLC7A11	therapeutic_target	gene	0.60
Caspase	activates	protein	0.60
Α-Synuclein	activates	protein	0.60
NRF2	activates	gene	0.60
oxidative stress response	participates_in	pathway	0.60
ferroptosis	participates_in	pathway	0.60
Neuron	expressed_in	cell_type	0.55

Incoming (27)

Source	Relation	Type	Str
SLC7A11	transports	gene	0.60
AND	transports	gene	0.60
SLC7A11	therapeutic_target	gene	0.60
NRF2	activates	gene	0.60
LC3	activates	gene	0.60
FERROPTOSIS	expressed_in	gene	0.60
FER	expressed_in	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
NCOA4	expressed_in	gene	0.60
ROS	activates	gene	0.60
ATG5	activates	gene	0.60
NEURON	activates	gene	0.60
GPX4	expressed_in	gene	0.60
COX2	expressed_in	gene	0.60
APOPTOSIS	activates	gene	0.60
PARKINSON	activates	gene	0.60
P62	activates	gene	0.60
FERROPTOSIS	therapeutic_target	gene	0.60
HO-1	activates	gene	0.60
BCL-2	activates	gene	0.60
MTOR	activates	gene	0.60
BAX	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

XCT

Understanding Entity Pages

Wiki Pages (14)

Ferroptosis in Neurodegeneration

Ferroptotic Neurons

Glutathione Metabolism Pathway

Synaptic Loss and Dysfunction Pathway

Ferroptosis

Neurotensin Signaling in Neurodegeneration

Ferroptosis Pathway in Neurodegeneration

Activating Transcription Factor 4 (ATF4)

SLC3A1 — Solute Carrier Family 3 Member 1

ATF4 Gene

SLC7A11 Gene - xCT Cystine/Glutamate Antiporter

xCT Protein - SLC7A11 Cystine/Glutamate Antiporter