concept

XCT

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about XCT: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

77Connections

1Hypotheses

1Analyses

49Outgoing

28Incoming

1Experiments

1Debates

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💡 Concept Info

Name	XCT
Key Genes/Proteins	APOPTOSIS, ATG5, AUTOPHAGY, BAX, BCL-2, CANCER
Related Diseases	Als, ALS, Cancer
Related Pathways	Apoptosis, Autophagy, ferroptosis

Pathway Diagram

graph TD
    XCT["XCT"]
    XCT -->|"regulates"| cystine["cystine"]
    XCT -->|"activates"| Tumor["Tumor"]
    XCT -->|"transports"| Cancer["Cancer"]
    XCT -->|"target for"| Ferroptosis["Ferroptosis"]
    XCT -->|"activates"| Parkinson["Parkinson"]
    XCT -->|"transports"| Als["Als"]
    NRF2["NRF2"] -->|"regulates"| XCT
    SLC7A11["SLC7A11"] -->|"encodes"| XCT
    Nrf2["Nrf2"] -->|"activates"| XCT
    AND["AND"] -->|"transports"| XCT
    LC3["LC3"] -->|"activates"| XCT

Outgoing (49)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:XCT	data_in	dataset_row	0.00
FERROPTOSIS	inhibits	process	0.80
oxidative stress	downregulates	process	0.80
GPX4	interacts_with	protein	0.75
cystine	regulates	drug	0.72
Cancer	transports	disease	0.65
Ferroptosis	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Als	associated_with	disease	0.65
ALS	associated_with	disease	0.65
Tumor	activates	disease	0.65
Parkinson	activates	disease	0.65
Ferroptosis	expressed_in	disease	0.65
Als	transports	disease	0.65
AUTOPHAGY	activates	gene	0.60
NCOA4	expressed_in	gene	0.60
FERROPTOSIS	expressed_in	gene	0.60
LC3	activates	gene	0.60
NEURON	activates	gene	0.60
GPX4	expressed_in	gene	0.60
ATG5	activates	gene	0.60
HO-1	activates	gene	0.60
P62	activates	gene	0.60
MTOR	activates	gene	0.60
BCL-2	activates	gene	0.60
PARKINSON	activates	gene	0.60
Oxidative Stress	activates	pathway	0.60
Autophagy	activates	pathway	0.60
Mtor	activates	pathway	0.60
Apoptosis	activates	pathway	0.60
Neuron	activates	cell_type	0.60
Caspase	activates	protein	0.60
Α-Synuclein	activates	protein	0.60
BAX	activates	gene	0.60
ROS	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
SLC7A11	therapeutic_target	gene	0.60
oxidative stress response	participates_in	pathway	0.60
ferroptosis	participates_in	pathway	0.60
SLC7A11	transports	gene	0.60
NRF2	activates	gene	0.60
CANCER	transports	gene	0.60
Ferroptosis	transports	pathway	0.60
FERROPTOSIS	therapeutic_target	gene	0.60
PARKINSON'S DISEASE	activates	gene	0.60
COX2	expressed_in	gene	0.60
FERROPTOSIS	transports	gene	0.60
Neuron	expressed_in	cell_type	0.55
glutathione synthesis	activates	process	0.50

Incoming (28)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:XCT	data_in	dataset_row	0.00
25384799	regulates	paper	0.90
25384799	is enriched in	paper	0.90
NRF2	regulates	protein	0.85
SLC7A11	encodes	gene	0.80
Nrf2	activates	transcription_factor	0.70
FERROPTOSIS	therapeutic_target	gene	0.60
SLC7A11	transports	gene	0.60
NRF2	activates	gene	0.60
GPX4	expressed_in	gene	0.60
COX2	expressed_in	gene	0.60
APOPTOSIS	activates	gene	0.60
PARKINSON	activates	gene	0.60
P62	activates	gene	0.60
HO-1	activates	gene	0.60
BCL-2	activates	gene	0.60
MTOR	activates	gene	0.60
BAX	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
SLC7A11	therapeutic_target	gene	0.60
LC3	activates	gene	0.60
FERROPTOSIS	expressed_in	gene	0.60
FER	expressed_in	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
NCOA4	expressed_in	gene	0.60
ROS	activates	gene	0.60
ATG5	activates	gene	0.60
NEURON	activates	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Microglial xCT/SLC7A11 Selective Inhibition to Reduce Non-Ce	0.620	-	Ferroptosis in ALS and motor neuron dise

Mentioning Analyses (1)

Scientific analyses that reference this entity

SEA-AD Single-Cell Analysis: Cell-Type Vulnerability in Alzheimer's Disease

neurodegeneration | 2026-04-04 | 0 hypotheses

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Gandouling protection against brain injury in Wilson's disease via SIR	validation	Hepatolenticular degeneration	0.900	0.00	TX mice (Wilson's disease mode	proposed	N/A

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

What are the cell-type specific vulnerability mechanisms in Alzheimer's disease

closed · Rounds: 4 · Score: 0.68 · 2026-04-04

Related Research

Hypotheses and analyses mentioning XCT in their description or question text

No additional research found