Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about NRF2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
NRF2 is a gene implicated in neurodegeneration research. Key relationships include: activates, regulates, inhibits. Associated with ALS, ALZHEIMER'S DISEASE, Aging. Connected to 1652 entities in the SciDEX knowledge graph.
| Gene Symbol | NRF2 |
| Chromosome | 2q31.2 |
| Protein Family | Cap'n'Collar (CNC) bZIP transcription factor |
| Function | Basal state: Keap1 homodimer binds NRF2 via the DLG and ETGE motifs, serving as a substrate adapter for the Cul3-RING ubiquitin E3 ligase complex. |
| Molecular Weight | 68 kDa |
| Amino Acids | 605 aa |
| Pathways | Akt, Apoptosis, Autophagy, Cell Cycle, Chaperone |
| GeneCards | NRF2 |
| Human Protein Atlas | NRF2 |
| 2012 | Company founded in Cheshire, UK |
| 2015 | LSE AIM IPO (ticker: EVG) |
| 2018 | SFX-01 enters Phase 2 clinical trials for PD and AD |
| 2020 | Positive Phase 2 data in subarachnoid hemorrhage |
| 2022 | Multiple Phase 2 trials ongoing in neurological indications |
| 2024 | Continued clinical development with SFX-01 in PD and AD [@evgen_r] |
| Associated Diseases | ALS, ALZHEIMER'S DISEASE, Aging, Alzheimer |
| Known Drugs/Compounds | RAPAMYCIN, KAEMPFEROL, GPS, EPS, VITAMINE, DMF |
| Interactions | GPX4, CX3CR1, TNF, CD163, CD68, ULK1 |
| KG Connections | 3350 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
NRF2["NRF2 Transcription Factor"] -->|"Inhibited by"| KEAP1["KEAP1 Repressor"]
NRF2 -->|"Activates"| ARE["Antioxidant Response Element"]
NRF2 -->|"Regulates"| OX["Oxidative Stress Response"]
NRF2 -->|"Inhibits"| INFLAM["Inflammation"]
NRF2 -->|"Regulates"| NFKB["NF-kappaB Pathway"]
ARE -->|"Induces"| HMOX1["HMOX1"]
ARE -->|"Induces"| NQO1["NQO1"]
ARE -->|"Induces"| SOD["SOD"]
ARE -->|"Induces"| GCLC["GCLC"]
ARE -->|"Induces"| GCLM["GCLM"]
ARE -->|"Induces"| SRXN1["SRXN1"]
ARE -->|"Induces"| TXNRD1["TXNRD1"]
GCLC -->|"Synthesizes"| GSH["Glutathione"]
GCLM -->|"Synthesizes"| GSH
NRF2 -->|"Implicated in"| ND["Neurodegeneration"]
NRF2 -->|"Associated with"| CCRCC["Clear Cell RCC"]
style NRF2 fill:#1b5e20,color:#e0e0e0
style KEAP1 fill:#b71c1c,color:#e0e0e0
style ARE fill:#0d47a1,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| AKT | activates | protein | 1.00 |
| SOD1 | associated_with | gene | 1.00 |
| Als | therapeutic_target | disease | 1.00 |
| Ferroptosis | inhibits | pathway | 1.00 |
| Inflammation | activates | disease | 1.00 |
| Neuroinflammation | activates | disease | 1.00 |
| Tumor | activates | disease | 1.00 |
| Stroke | activates | disease | 1.00 |
| Autophagy | activates | pathway | 1.00 |
| Ferroptosis | activates | pathway | 1.00 |
| Apoptosis | activates | pathway | 1.00 |
| Als | inhibits | disease | 1.00 |
| Als | activates | disease | 1.00 |
| Oxidative Stress | activates | pathway | 1.00 |
| Nf-Κb | activates | pathway | 1.00 |
| Oxidative Stress | regulates | pathway | 1.00 |
| Nf-Κb | regulates | pathway | 1.00 |
| Cancer | regulates | disease | 1.00 |
| Inflammation | regulates | disease | 1.00 |
| Inflammation | therapeutic_target | disease | 1.00 |
| Als | regulates | disease | 1.00 |
| Neurodegeneration | activates | disease | 1.00 |
| Parkinson | activates | disease | 1.00 |
| Cancer | activates | disease | 1.00 |
| Alzheimer | activates | disease | 1.00 |
| Oxidative Stress | inhibits | pathway | 1.00 |
| Autophagy | regulates | pathway | 1.00 |
| Oxidative Stress | associated_with | pathway | 1.00 |
| Cancer | therapeutic_target | disease | 1.00 |
| Tumor | inhibits | disease | 1.00 |
| Carcinoma | activates | disease | 1.00 |
| Aging | therapeutic_target | disease | 1.00 |
| Parkinson | therapeutic_target | disease | 1.00 |
| Cancer | inhibits | disease | 1.00 |
| Apoptosis | regulates | pathway | 1.00 |
| Inflammation | inhibits | disease | 1.00 |
| Cardiac | activates | disease | 1.00 |
| AUTOPHAGY | activates | gene | 1.00 |
| Apoptosis | inhibits | pathway | 1.00 |
| OXIDATIVE STRESS | regulates | gene | 1.00 |
| Aging | regulates | disease | 1.00 |
| Ferroptosis | regulates | pathway | 1.00 |
| OXIDATIVE STRESS | inhibits | gene | 1.00 |
| Mapk | inhibits | pathway | 1.00 |
| NEUROINFLAMMATION | activates | gene | 1.00 |
| Pi3K/Akt | activates | pathway | 1.00 |
| OXIDATIVE STRESS | associated_with | gene | 1.00 |
| MITOCHONDRIA | activates | gene | 1.00 |
| OXIDATIVE STRESS | activates | gene | 1.00 |
| Nf-Κb | inhibits | pathway | 1.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| KEAP1 | regulates | gene | 1.00 |
| P62 | activates | protein | 1.00 |
| KEAP1 | inhibits | protein | 1.00 |
| KEAP1 | activates | gene | 1.00 |
| GPX4 | activates | gene | 1.00 |
| PI3K | activates | gene | 1.00 |
| GPX4 | inhibits | gene | 1.00 |
| SQSTM1 | activates | gene | 1.00 |
| TMEM16F | regulates | gene | 1.00 |
| ROS | activates | phenotype | 1.00 |
| INFLAMMATION | activates | phenotype | 1.00 |
| GENES | regulates | gene | 1.00 |
| GENES | activates | gene | 1.00 |
| HO-1 | activates | gene | 1.00 |
| HO-1 | inhibits | gene | 1.00 |
| OXIDATIVE STRESS | associated_with | gene | 1.00 |
| FERROPTOSIS | inhibits | gene | 1.00 |
| OXIDATIVE STRESS | activates | gene | 1.00 |
| CANCER | activates | gene | 1.00 |
| CANCER | regulates | gene | 1.00 |
| NEURODEGENERATION | activates | gene | 1.00 |
| INFLAMMATION | regulates | gene | 1.00 |
| NF-ΚB | regulates | gene | 1.00 |
| APOPTOSIS | regulates | gene | 1.00 |
| OXIDATIVE STRESS | regulates | gene | 1.00 |
| APOPTOSIS | associated_with | gene | 1.00 |
| INFLAMMATION | therapeutic_target | gene | 1.00 |
| OXIDATIVE STRESS | inhibits | gene | 1.00 |
| NF-ΚB | activates | gene | 1.00 |
| CYTOKINES | activates | gene | 1.00 |
| CANCER | therapeutic_target | gene | 1.00 |
| INFLAMMATION | inhibits | gene | 1.00 |
| NEURODEGENERATIVE DISEASES | activates | gene | 1.00 |
| ROS | regulates | gene | 1.00 |
| NEURODEGENERATION | associated_with | gene | 1.00 |
| NF-KB | associated_with | protein | 1.00 |
| ALZHEIMER'S DISEASE | associated_with | disease | 1.00 |
| KEAP1 | associated_with | gene | 1.00 |
| GENES | associated_with | gene | 1.00 |
| HO-1 | regulates | gene | 1.00 |
| CANCER | inhibits | gene | 1.00 |
| OXIDATIVE STRESS | therapeutic_target | gene | 1.00 |
| PARKINSON'S DISEASE | therapeutic_target | gene | 1.00 |
| PARKINSON'S DISEASE | activates | gene | 1.00 |
| NEURODEGENERATIVE DISEASES | regulates | gene | 1.00 |
| BCL-2 | activates | gene | 1.00 |
| ROS | inhibits | gene | 1.00 |
| PARKINSON | therapeutic_target | gene | 1.00 |
| FERROPTOSIS | activates | gene | 0.98 |
| MCL | activates | drug | 0.95 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
neurodegeneration | 2026-04-14 | 0 hypotheses
neurodegeneration | 2026-04-03 | 14 hypotheses Top: 0.622
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.552
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||