gene 776 words KG: CTSD
Contents

CTSD — Cathepsin D

🧬 Gene Info
Gene SymbolCTSD
Full NameCathepsin D
AliasesCPSD, CLN10
Chromosome11p15.5
Protein TypeProtease
Functionis a lysosomal aspartic protease encoded by the CTSD gene.
Primary ExpressionBrain, liver, macrophages, neurons, microglia
Molecular Weight48 kDa
PathwaysAkt, Angiogenesis, Apoptosis, Autophagy, Blood-Brain Barrier
UniProt IDP07339
NCBI Gene ID1509
Ensembl IDENSG00000103811
GeneCardsCTSD
Human Protein AtlasCTSD
Pre-proenzymeSignal peptide + prosegment + mature enzyme
Associated DiseasesAD, ADH, Aging, ALI, Als
Known Drugs/CompoundsCHLOROQUINE, COENZYME Q10, H2S, rapamycin, RAPAMYCIN
InteractionsABCA1, ABCD3, ACTB, Actin, ADRA2A, AGING
SciDEX HypothesesCathepsin D Enhancement for Tau Degradation
KG Connections1554 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (37)

Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.70
Mitochondrial Transfer Pathway Enhancement
Score: 0.70
Lysosomal Positioning Dynamics Modulation
Score: 0.69
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
Oligodendrocyte Protectin D1 Mimetic for Myelin Resolution
Score: 0.68
RAB27A-dependent extracellular vesicle engineering for mitoc
Score: 0.67
Metabolic Reprogramming via Microglial Glycolysis Inhibition
Score: 0.67
Mitochondrial-Lysosomal Contact Site Engineering
Score: 0.67
RNA Granule Nucleation Site Modulation
Score: 0.66
Optogenetic Microglial Deactivation via Engineered Inhibitor
Score: 0.66
The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction
Score: 0.65
Quantum Coherence Disruption in Cellular Communication
Score: 0.63
TREM2-mediated microglial tau clearance enhancement
Score: 0.62
LRP1-Dependent Tau Uptake Disruption
Score: 0.60
Synaptic Vesicle Tau Capture Inhibition
Score: 0.58
Fractalkine Axis Amplification via CX3CR1 Positive Allosteri
Score: 0.56
Restoring Neuroprotective Tryptophan Metabolism via Targeted
Score: 0.61
← Prevpg 2/2

Related Analyses (12)

Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived

Related Experiments (2)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40
Experiment: Multi-Ethnic PD GWAS
clinical · proposed · Score: 0.40

See Also (8)

ABCA1 - ATP-Binding Cassette Transporter A1
gene · KG edge: associated_with
ABCD3 Gene
gene · KG edge: interacts_with
ACSL4 Gene - Acyl-CoA Synthetase Long Chain Family Memb
gene · KG edge: debate_co_mention
ACTB Gene
gene · KG edge: associated_with
ADAM10 — A Disintegrin And Metalloproteinase Domain 10
gene · KG edge: therapeutic_target

Knowledge Graph (12 edges)

ACTB regulates CTSD
PPARA regulates CTSD
CAT regulates CTSD
SQSTM1 regulates CTSD
RPS6KB1 regulates CTSD
RAB7A regulates CTSD
SREBF1 regulates CTSD
EIF4EBP1 regulates CTSD
CTSD regulates PPARGC1A
CTSD regulates LRP2

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