Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about MMP2/MMP9: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | MMP2/MMP9 |
| Key Genes/Proteins | GFAP, S100A8, TNF, MMP9, MMP2, TLR4 |
| Related Diseases | Spinal Cord Injury, Melanoma, Cancer, Tumor, Ms |
Knowledge base pages for this entity
graph TD
MMP2_MMP9["MMP2/MMP9"]
MMP2_MMP9 -->|"inhibits"| Spinal_Cord_Injury["Spinal Cord Injury"]
MMP2_MMP9 -->|"target for"| Melanoma["Melanoma"]
MMP2_MMP9 -->|"target for"| Cancer["Cancer"]
MMP2_MMP9 -->|"regulates"| Tumor["Tumor"]
MMP2_MMP9 -->|"inhibits"| Ms["Ms"]
MMP2_MMP9 -->|"inhibits"| GFAP["GFAP"]
MMP2_MMP9 -->|"inhibits"| S100A8["S100A8"]
MMP2_MMP9 -->|"inhibits"| TNF["TNF"]
TLR4["TLR4"] -->|"activates"| MMP2_MMP9
NF__B["NF-KappaB"] -->|"activates"| MMP2_MMP9
CD68["CD68"] -->|"inhibits"| MMP2_MMP9
TNF__["TNF-Alpha"] -->|"inhibits"| MMP2_MMP9
GENES["GENES"] -->|"inhibits"| MMP2_MMP9
CD47["CD47"] -->|"inhibits"| MMP2_MMP9
AND["AND"] -->|"target for"| MMP2_MMP9
MMP2["MMP2"] -->|"regulates"| MMP2_MMP9| Target | Relation | Type | Str |
|---|---|---|---|
| Spinal Cord Injury | inhibits | disease | 0.65 |
| Melanoma | therapeutic_target | disease | 0.65 |
| Cancer | therapeutic_target | disease | 0.65 |
| Tumor | regulates | disease | 0.65 |
| Ms | inhibits | disease | 0.65 |
| MMP9 | inhibits | entity | 0.60 |
| TLR4 | inhibits | entity | 0.60 |
| GFAP | inhibits | gene | 0.60 |
| S100A8 | inhibits | gene | 0.60 |
| TNF | inhibits | gene | 0.60 |
| MMP9 | activates | gene | 0.60 |
| MMP2 | activates | gene | 0.60 |
| TLR4 | activates | gene | 0.60 |
| CD68 | inhibits | gene | 0.60 |
| CD47 | inhibits | gene | 0.60 |
| MMP9 | regulates | gene | 0.60 |
| IL-6 | inhibits | gene | 0.60 |
| Nf-Κb | activates | pathway | 0.60 |
| GENES | inhibits | gene | 0.60 |
| TNF-Α | inhibits | gene | 0.60 |
| NF-ΚB | activates | gene | 0.60 |
| AND | inhibits | gene | 0.60 |
| neurodegeneration | promoted: SASP-Mediated Cholinergic Synapse Disruption | disease | 0.56 |
| Spinal Cord | expressed_in | brain_region | 0.55 |
| Neuron | expressed_in | cell_type | 0.55 |
| senescence | activates | process | 0.55 |
| neurodegeneration | associated_with | disease | 0.50 |
| NAMPT | debate_co_mention | gene | 0.45 |
| PLA2G6/PLA2G4A | debate_co_mention | gene | 0.45 |
| SLC7A11 | debate_co_mention | gene | 0.45 |
| MMP9 | debate_co_mention | gene | 0.45 |
| neuroinflammation | debate_co_mention | process | 0.45 |
| PLA2G6 | debate_co_mention | gene | 0.45 |
| senescence | debate_co_mention | process | 0.45 |
| PLA2G6/PLA2G4A | co_associated_with | gene | 0.40 |
| Source | Relation | Type | Str |
|---|---|---|---|
| MMP2 | activates | entity | 0.60 |
| MMP2 | inhibits | entity | 0.60 |
| TLR4 | activates | gene | 0.60 |
| CD68 | inhibits | gene | 0.60 |
| CD47 | inhibits | gene | 0.60 |
| MMP2 | regulates | gene | 0.60 |
| TNF | inhibits | gene | 0.60 |
| S100A8 | inhibits | gene | 0.60 |
| MMP9 | activates | gene | 0.60 |
| GFAP | inhibits | gene | 0.60 |
| NF-ΚB | activates | gene | 0.60 |
| TNF-Α | inhibits | gene | 0.60 |
| GENES | inhibits | gene | 0.60 |
| AND | therapeutic_target | gene | 0.60 |
| CANCER | therapeutic_target | gene | 0.60 |
| IL-6 | inhibits | gene | 0.60 |
| AND | inhibits | gene | 0.60 |
| CGAS | debate_co_mention | gene | 0.45 |
| ferroptosis | debate_co_mention | pathway | 0.45 |
| GPX4 | debate_co_mention | gene | 0.45 |
| GPX4/SLC7A11 | debate_co_mention | gene | 0.45 |
| IL1B | debate_co_mention | gene | 0.45 |
| MMP2 | debate_co_mention | gene | 0.45 |
| mitophagy | debate_co_mention | pathway | 0.45 |
| CGAS/STING1/DNASE2 | co_associated_with | gene | 0.40 |
| C1Q/C3 | co_associated_with | gene | 0.40 |
| GPX4/SLC7A11 | co_associated_with | gene | 0.40 |
| AQP4 | co_associated_with | gene | 0.40 |
| CD38/NAMPT | co_associated_with | gene | 0.40 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| SASP-Mediated Cholinergic Synapse Disruption | 0.564 | neurodegeneration | Senolytic therapy for age-related neurod |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 8 hypotheses Top: 0.703
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Clinical, Immunological, and Vesicular Markers in Sarcopenia and Presarcopenia. [PMID:40917056] | Shuliko LM, Svarovsky DA, Spirina LV, Og | Front Biosci (Landmark Ed) | 2025 | 1 |
| CD47-blocking antibody interferes with neutrophil extracellular traps formation [PMID:39951937] | Diao Y, Hao M, Xie M, Hu X, Tan R, Wang | J Neuroimmunol | 2025 | 1 |
| Asparagine Endopeptidase Inhibition Attenuates Tissue Plasminogen Activator-Indu [PMID:40116141] | Xie G, Jiang G, Huang L, Sun S, Li X, Wu | CNS Neurosci Ther | 2025 | 1 |
| Enhanced anticancer activity of nanoemulsified cardamom extract via modulation o [PMID:41658858] | ["Soltani T", "Karimian M", "Vaziri H", | Biochemistry and biophysics re | 2026 | 0 |
| Integrated transcriptomic, proteomic, and metabolomic analyses reveal molecular [PMID:41850064] | ["Wang H", "Liu Y", "Jiang K", "Yin J", | Poultry science | 2026 | 0 |
| Fragment merging design, synthesis, and biological evaluation of novel methyl Se [PMID:41785527] | ["Shaaban S", "Hawas S", "Elmaaty A", "B | Bioorganic & medicinal chemist | 2026 | 0 |
| Theranekron modulates extracellular matrix and apoptotic signaling pathways in c [PMID:41852375] | ["Kuccukturk S", "Duran T", "Vanli S", " | Cytotechnology | 2026 | 0 |
| Saliva liquid biopsy: MMP2, MMP9, and TIMP2 as potential diagnostic biomarkers i [PMID:41779471] | ["Cruz-Romero S", "Baldi\u00f3n A", "Taw | Journal of applied oral scienc | 2026 | 0 |
| Glomerular Transcriptome Analysis Reveals Endothelial Disturbances in Patients W [PMID:41659822] | ["Nelson-Taylor S", "Troost J", "Giannin | Kidney medicine | 2026 | 0 |
| Encapsulation of hydroxyurea in exosomes derived from adipose mesenchymal stem c [PMID:41702234] | ["Taheri Kangarshahi Z", "Ganji S", "Ash | Translational oncology | 2026 | 0 |
| NSUN2 promoted tumor growth and metastatic via m [PMID:41794778] | ["Li R", "Jin D", "Shao S", "Guo J"] | Cell death & disease | 2026 | 0 |
| Membrane-Type 5 Matrix Metalloproteinase (MT5-MMP): Background and Proposed Role [PMID:40867559] | ["Jadhav D", "Knapinska A", "Wang H", "F | Biomolecules | 2025 | 0 |
| Pyridostigmine Treatment Significantly Alleviates Isoprenaline-Induced Chronic H [PMID:40725139] | Marinković ST, Sobot T, Maksimović ŽM, Ð | International journal of molec | 2025 | 0 |
| Effects of Mono- (2-ethylhexyl) phthalate and Phthalic Acid Monobenzyl Ester on [PMID:40769497] | ["Wu Q", "Sun Y", "Liu Q", "Zhao X", "Li | Reproductive toxicology (Elmsf | 2025 | 0 |
| Targeting Invasion: The Role of MMP-2 and MMP-9 Inhibition in Colorectal Cancer [PMID:39858430] | ["Shoari A", "Ashja Ardalan A", "Dimesa | Biomolecules | 2024 | 0 |
| Effects of MMP2 and its inhibitor TIMP2 on DNA damage, apoptosis and senescence [PMID:39538054] | ["Deng X", "Zhang Y", "He X", "Li L", "Y | Journal of bioenergetics and b | 2024 | 0 |
| Biological significance and pathophysiological role of Matrix Metalloproteinases [PMID:39322129] | ["Ganguly K", "Adhikary K", "Acharjee A" | International journal of biolo | 2024 | 0 |
| Reduced inhibitory and excitatory input onto parvalbumin interneurons mediated b [PMID:36543316] | ["Zhang L", "Gao Y", "Zhao C", "Xia J", | Neuropharmacology | 2023 | 0 |
| Unlocking the potential of iridium and ruthenium arene complexes as anti-tumor a [PMID:36370504] | Lv M, Qian X, Li S, Gong J, Wang Q, Qian | Journal of inorganic biochemis | 2023 | 0 |
| Low protein-induced intrauterine growth restriction as a risk factor for schizop [PMID:36720849] | ["Allg\u00e4uer L", "Cabungcal J", "Yzyd | Translational psychiatry | 2023 | 0 |