| Gene Symbol | RIPK1 |
| Aliases | Receptor-Interacting Serine/Threonine-Protein Kinase 1 |
| Protein Type | Kinase |
| Function | Complex I formation: TNFR1 recruits TRADD, RIPK1, TRAF2/5, and cIAP1/2 into a membrane-associated complex |
| Subcellular Localization | </td><td>Cytoplasm, plasma membrane (TNFR1 complex)</td></tr> |
| Molecular Weight | 75 kDa |
| Amino Acids | 671 aa |
| Exons | 9 |
| Pathways | NF-κB signaling, NF-κB |
| GeneCards | RIPK1 |
| Human Protein Atlas | RIPK1 |
| Associated Diseases | ALS, Alzheimer, Alzheimer's disease, Amyotrophic Lateral Sclerosis, Cancer |
| Known Drugs/Compounds | RAPAMYCIN, Cadmium, Metformin, rapamycin, metformin, Necrostatin |
| Interactions | MAPK14, BECN1, ATF6, DDIT3, NBR1, HSP70 |
| KG Connections | 1508 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |