REV-ERB Agonist Microglial Deactivation

flowchart TD
    A["Microglial Chronic Activation<br/>AD Neuroinflammatory State"]
    B["Circadian Clock Dysregulation<br/>BMAL1 CLOCK Disrupted"]
    C["REV-ERB Alpha NR1D1<br/>Nuclear Receptor Expressed in Microglia"]
    D["Synthetic REV-ERB Agonist<br/>SR9009 SR9011 Treatment"]
    E["NR1D1 NR1D2 Activation<br/>Transcriptional Repressor Function"]
    F["IL-6 TNF-alpha NLRP3 Suppressed<br/>Inflammatory Gene Repression"]
    G["Microglial Deactivation<br/>DAM to Homeostatic Transition"]
    H["Neuroprotection<br/>Amyloid and Tau Pathology Reduced"]
    A --> B
    B --> C
    C --> D
    D --> E
    E --> F
    F --> G
    G --> H
    style E fill:#1a237e,stroke:#4fc3f7,color:#4fc3f7
    style H fill:#1b5e20,stroke:#a5d6a7,color:#a5d6a7