gene

PLIN3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PLIN3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

208Connections
0Hypotheses
0Analyses
50Outgoing
50Incoming

Summary

PLIN3 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, activates, associated with. Associated with Hepatitis, Neurodegeneration, Tumor. Connected to 91 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolPLIN3
Functionencodes a lipid droplet-associated protein that plays crucial roles in lipid metabolism, autophagy regulation, and lysosomal function.
Primary Expressionvarious tissues with specific patterns:
Molecular Weight47 kDa
Pathwaysautophagy pathway, Phagocytosis, Mtor, Autophagy, complement cascade
Ensembl IDENSG00000138326
GeneCardsPLIN3
Human Protein AtlasPLIN3
Coats lipid droplet surfaceForms a monomolecular layer on the droplet surface
Regulates sizeControls lipid droplet growth and coalescence
Prevents lipolysisProtects stored triglycerides from ATGL-mediated hydrolysis
Recruits proteinsAttracts lipases and other regulatory proteins
Lipid droplet recognitionPLIN3 marks droplets for selective autophagy
Autophagosome recruitmentFacilitates LC3 binding to lipid droplets
Lysosomal fusionCoordinates droplet delivery to lysosomes
Associated DiseasesNeurodegeneration
Known Drugs/Compoundsrapamycin
InteractionsBECN1, GRK2, FOXO1, NR1H3, MAP3K5, SREBF2
KG Connections208 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Wiki Pages (10)

Knowledge base pages for this entity

Canonical Page

plin3

gene · 1408 words

PLIN1 — Perilipin 1

gene · 2940 words

PLIN5 — Perilipin 5

gene · 2823 words

PLIN4 Gene

gene · 1879 words

PLIN2 Gene

gene · 1479 words

TFEB Activators for Parkinson's Disease

mechanism · 1450 words

Pathway Diagram

flowchart TD
    PLIN3["PLIN3"] -->|"interacts with"| Tumor["Tumor"]
    PLIN3["PLIN3"] -->|"interacts with"| Hepatitis["Hepatitis"]
    PLIN3["PLIN3"] -->|"interacts with"| BECN1["BECN1"]
    PLIN3["PLIN3"] -->|"interacts with"| GRK2["GRK2"]
    PLIN3["PLIN3"] -->|"interacts with"| FOXO1["FOXO1"]
    PLIN3["PLIN3"] -->|"interacts with"| NR1H3["NR1H3"]
    PLIN3["PLIN3"] -->|"interacts with"| MAP3K5["MAP3K5"]
    PLIN3["PLIN3"] -->|"interacts with"| SREBF2["SREBF2"]
    PLIN3["PLIN3"] -->|"interacts with"| NFE2L2["NFE2L2"]
    PLIN3["PLIN3"] -->|"interacts with"| C1Q["C1Q"]
    PLIN3["PLIN3"] -->|"interacts with"| HTRA2["HTRA2"]
    PLIN3["PLIN3"] -->|"interacts with"| MTOR["MTOR"]
    style PLIN3 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style Tumor fill:#ef5350,stroke:#333,color:#e0e0e0
    style Hepatitis fill:#ef5350,stroke:#333,color:#e0e0e0
    style BECN1 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style GRK2 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style FOXO1 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style NR1H3 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style MAP3K5 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style SREBF2 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style NFE2L2 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style C1Q fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style HTRA2 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style MTOR fill:#4a1a6b,stroke:#333,color:#e0e0e0

Outgoing (112)

TargetRelationTypeStr
autophagy pathwayparticipates_inpathway0.70
Tumorinteracts_withdisease0.65
Hepatitisinteracts_withdisease0.65
Neurodegenerationassociated_withdisease0.65
Neurodegenerationinhibitsdisease0.65

Incoming (96)

SourceRelationTypeStr
PPARAinteracts_withgene0.60
ULK1interacts_withgene0.60
STX17interacts_withgene0.60
SQSTM1interacts_withgene0.60
NOS3interacts_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found