Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PLIN3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
PLIN3 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, activates, associated with. Associated with Hepatitis, Neurodegeneration, Tumor. Connected to 91 entities in the SciDEX knowledge graph.
| Gene Symbol | PLIN3 |
| Function | encodes a lipid droplet-associated protein that plays crucial roles in lipid metabolism, autophagy regulation, and lysosomal function. |
| Primary Expression | various tissues with specific patterns: |
| Molecular Weight | 47 kDa |
| Pathways | autophagy pathway, Phagocytosis, Mtor, Autophagy, complement cascade |
| Ensembl ID | ENSG00000138326 |
| GeneCards | PLIN3 |
| Human Protein Atlas | PLIN3 |
| Coats lipid droplet surface | Forms a monomolecular layer on the droplet surface |
| Regulates size | Controls lipid droplet growth and coalescence |
| Prevents lipolysis | Protects stored triglycerides from ATGL-mediated hydrolysis |
| Recruits proteins | Attracts lipases and other regulatory proteins |
| Lipid droplet recognition | PLIN3 marks droplets for selective autophagy |
| Autophagosome recruitment | Facilitates LC3 binding to lipid droplets |
| Lysosomal fusion | Coordinates droplet delivery to lysosomes |
| Associated Diseases | Neurodegeneration |
| Known Drugs/Compounds | rapamycin |
| Interactions | BECN1, GRK2, FOXO1, NR1H3, MAP3K5, SREBF2 |
| KG Connections | 208 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
flowchart TD
PLIN3["PLIN3"] -->|"interacts with"| Tumor["Tumor"]
PLIN3["PLIN3"] -->|"interacts with"| Hepatitis["Hepatitis"]
PLIN3["PLIN3"] -->|"interacts with"| BECN1["BECN1"]
PLIN3["PLIN3"] -->|"interacts with"| GRK2["GRK2"]
PLIN3["PLIN3"] -->|"interacts with"| FOXO1["FOXO1"]
PLIN3["PLIN3"] -->|"interacts with"| NR1H3["NR1H3"]
PLIN3["PLIN3"] -->|"interacts with"| MAP3K5["MAP3K5"]
PLIN3["PLIN3"] -->|"interacts with"| SREBF2["SREBF2"]
PLIN3["PLIN3"] -->|"interacts with"| NFE2L2["NFE2L2"]
PLIN3["PLIN3"] -->|"interacts with"| C1Q["C1Q"]
PLIN3["PLIN3"] -->|"interacts with"| HTRA2["HTRA2"]
PLIN3["PLIN3"] -->|"interacts with"| MTOR["MTOR"]
style PLIN3 fill:#4a1a6b,stroke:#333,color:#e0e0e0
style Tumor fill:#ef5350,stroke:#333,color:#e0e0e0
style Hepatitis fill:#ef5350,stroke:#333,color:#e0e0e0
style BECN1 fill:#4a1a6b,stroke:#333,color:#e0e0e0
style GRK2 fill:#4a1a6b,stroke:#333,color:#e0e0e0
style FOXO1 fill:#4a1a6b,stroke:#333,color:#e0e0e0
style NR1H3 fill:#4a1a6b,stroke:#333,color:#e0e0e0
style MAP3K5 fill:#4a1a6b,stroke:#333,color:#e0e0e0
style SREBF2 fill:#4a1a6b,stroke:#333,color:#e0e0e0
style NFE2L2 fill:#4a1a6b,stroke:#333,color:#e0e0e0
style C1Q fill:#4a1a6b,stroke:#333,color:#e0e0e0
style HTRA2 fill:#4a1a6b,stroke:#333,color:#e0e0e0
style MTOR fill:#4a1a6b,stroke:#333,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| autophagy pathway | participates_in | pathway | 0.70 |
| Tumor | interacts_with | disease | 0.65 |
| Hepatitis | interacts_with | disease | 0.65 |
| Neurodegeneration | associated_with | disease | 0.65 |
| Neurodegeneration | inhibits | disease | 0.65 |
| BECN1 | interacts_with | gene | 0.60 |
| GRK2 | interacts_with | gene | 0.60 |
| FOXO1 | interacts_with | gene | 0.60 |
| NR1H3 | interacts_with | gene | 0.60 |
| MAP3K5 | interacts_with | gene | 0.60 |
| SREBF2 | interacts_with | gene | 0.60 |
| NFE2L2 | interacts_with | gene | 0.60 |
| C1Q | interacts_with | gene | 0.60 |
| HTRA2 | interacts_with | gene | 0.60 |
| MTOR | interacts_with | gene | 0.60 |
| SIRT3 | interacts_with | gene | 0.60 |
| PLIN2 | interacts_with | gene | 0.60 |
| TP53 | interacts_with | gene | 0.60 |
| STING1 | interacts_with | gene | 0.60 |
| GLP1R | interacts_with | gene | 0.60 |
| SREBF1 | interacts_with | gene | 0.60 |
| NOS3 | interacts_with | gene | 0.60 |
| LC3 | interacts_with | gene | 0.60 |
| PRKAA2 | interacts_with | gene | 0.60 |
| RPTOR | interacts_with | gene | 0.60 |
| SQSTM1 | interacts_with | gene | 0.60 |
| PPARA | interacts_with | gene | 0.60 |
| LAMP2 | interacts_with | gene | 0.60 |
| ULK1 | interacts_with | gene | 0.60 |
| STX17 | interacts_with | gene | 0.60 |
| SIRT1 | interacts_with | gene | 0.60 |
| TFEB | interacts_with | gene | 0.60 |
| KDM6B | interacts_with | gene | 0.60 |
| LC3 | activates | gene | 0.60 |
| LAMP1 | activates | gene | 0.60 |
| PPARA | activates | entity | 0.60 |
| PRKAA2 | activates | entity | 0.60 |
| RPTOR | activates | entity | 0.60 |
| SIRT1 | activates | entity | 0.60 |
| SIRT3 | activates | entity | 0.60 |
| SQSTM1 | activates | entity | 0.60 |
| SREBF1 | activates | entity | 0.60 |
| SREBF2 | activates | entity | 0.60 |
| STING1 | activates | entity | 0.60 |
| STX17 | activates | entity | 0.60 |
| TFEB | activates | entity | 0.60 |
| TP53 | activates | entity | 0.60 |
| ULK1 | activates | entity | 0.60 |
| P62 | interacts_with | gene | 0.60 |
| BECN1 | activates | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| PPARA | interacts_with | gene | 0.60 |
| ULK1 | interacts_with | gene | 0.60 |
| STX17 | interacts_with | gene | 0.60 |
| SQSTM1 | interacts_with | gene | 0.60 |
| NOS3 | interacts_with | gene | 0.60 |
| STING1 | interacts_with | gene | 0.60 |
| GLP1R | interacts_with | gene | 0.60 |
| SREBF1 | interacts_with | gene | 0.60 |
| SIRT1 | interacts_with | gene | 0.60 |
| KDM6B | interacts_with | gene | 0.60 |
| LC3 | interacts_with | gene | 0.60 |
| RPTOR | interacts_with | gene | 0.60 |
| PRKAA2 | interacts_with | gene | 0.60 |
| LAMP2 | interacts_with | gene | 0.60 |
| FOXO1 | interacts_with | gene | 0.60 |
| TFEB | interacts_with | gene | 0.60 |
| MTOR | interacts_with | gene | 0.60 |
| P62 | interacts_with | gene | 0.60 |
| NR1H3 | interacts_with | gene | 0.60 |
| MAP3K5 | interacts_with | gene | 0.60 |
| BECN1 | interacts_with | gene | 0.60 |
| HTRA2 | interacts_with | gene | 0.60 |
| GRK2 | interacts_with | gene | 0.60 |
| NFE2L2 | interacts_with | gene | 0.60 |
| TP53 | interacts_with | gene | 0.60 |
| SREBF2 | interacts_with | gene | 0.60 |
| PLIN2 | interacts_with | gene | 0.60 |
| C1Q | interacts_with | gene | 0.60 |
| PLIN2 | activates | gene | 0.60 |
| BECN1 | activates | gene | 0.60 |
| ATG5 | activates | gene | 0.60 |
| C1Q | activates | entity | 0.60 |
| FOXO1 | activates | entity | 0.60 |
| GLP1R | activates | entity | 0.60 |
| GRK2 | activates | entity | 0.60 |
| HTRA2 | activates | entity | 0.60 |
| KDM6B | activates | entity | 0.60 |
| LAMP2 | activates | entity | 0.60 |
| LC3 | activates | entity | 0.60 |
| MAP3K5 | activates | entity | 0.60 |
| MTOR | activates | entity | 0.60 |
| NFE2L2 | activates | entity | 0.60 |
| NOS3 | activates | entity | 0.60 |
| NR1H3 | activates | entity | 0.60 |
| P62 | activates | entity | 0.60 |
| LAMP1 | activates | gene | 0.60 |
| SIRT3 | interacts_with | gene | 0.60 |
| ATG5 | biomarker_for | gene | 0.60 |
| BECN1 | biomarker_for | gene | 0.60 |
| LAMP1 | biomarker_for | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||