gene

KDM6B

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about KDM6B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

219Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

KDM6B is a gene implicated in neurodegeneration research. Key relationships include: interacts with, activates, expressed in. Associated with ALS, Als, Hepatitis. Connected to 96 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	KDM6B
Full Name	Lysine Demethylase 6B
Aliases	JMJD3
Chromosome	17p13.1
Function	encodes a Jumonji C (JmjC) domain-containing histone demethylase that specifically removes di- and trimethyl marks from histone H3 lysine 27 (H3K27me2/3).
Pathways	NF-κB
UniProt ID	[O15054](https://www.uniprot.org/uniprot/O15054)
Ensembl ID	ENSG00000132510
GeneCards	KDM6B
Human Protein Atlas	KDM6B
Neuronal differentiation	KDM6B removes H3K27me3 from neurogenic gene promoters during the transition from neural stem cells to postmitotic neurons, activating expression of NEUROD1, TBR1, and other neuronal identity genes
Macrophage polarization	KDM6B drives M1 (pro-inflammatory) macrophage/microglial polarization by activating inflammatory gene programs
Aging epigenome	KDM6B expression increases with aging, contributing to the progressive loss of H3K27me3 that characterizes the aging epigenome and potentially derepressing deleterious gene programs
Neuroinflammatory amplification	KDM6B removes H3K27me3 from pro-inflammatory gene promoters (TNF, IL1B, IL6, complement components), converting microglia to a chronic inflammatory state that damages neurons
[Tau](/proteins/tau) pathology	KDM6B activates kinase genes (CDK5, GSK3B) that hyperphosphorylate tau, promoting neurofibrillary tangle formation
Associated Diseases	NAFLD, NASH
Known Drugs/Compounds	rapamycin
Interactions	LC3, ATG7, RPTOR, PRKAA2, LAMP2, PLIN3
KG Connections	219 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    KDM6B["KDM6B"] -->|"activates"| Als["Als"]
    KDM6B["KDM6B"] -->|"interacts"| Tumor["Tumor"]
    KDM6B["KDM6B"] -->|"interacts"| Hepatitis["Hepatitis"]
    KDM6B["KDM6B"] -->|"activates"| ALS["ALS"]
    KDM6B["KDM6B"] -->|"activates"| LC3["LC3"]
    KDM6B["KDM6B"] -->|"activates"| ATG7["ATG7"]
    FGF21["FGF21"] -->|"activates"| KDM6B["KDM6B"]
    ULK1["ULK1"] -->|"activates"| KDM6B["KDM6B"]
    PPARA["PPARA"] -->|"interacts"| KDM6B["KDM6B"]
    ULK1_1["ULK1"] -->|"interacts"| KDM6B["KDM6B"]
    style KDM6B fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (142)

Target	Relation	Type	Str
autophagy pathway	participates_in	pathway	0.70
Als	activates	disease	0.65
Tumor	interacts_with	disease	0.65
Hepatitis	interacts_with	disease	0.65
ALS	activates	disease	0.65
GLUTAMATE	regulates	phenotype	0.65
NEURONS	causes	cell_type	0.65
NEURONS	treats	cell_type	0.65
LC3	activates	gene	0.60
ATG7	activates	gene	0.60
LC3	interacts_with	gene	0.60
RPTOR	interacts_with	gene	0.60
PRKAA2	interacts_with	gene	0.60
LAMP2	interacts_with	gene	0.60
PLIN3	interacts_with	gene	0.60
BECN1	interacts_with	gene	0.60
GRK2	interacts_with	gene	0.60
FOXO1	interacts_with	gene	0.60
NR1H3	interacts_with	gene	0.60
MAP3K5	interacts_with	gene	0.60
SREBF2	interacts_with	gene	0.60
NFE2L2	interacts_with	gene	0.60
C1Q	interacts_with	gene	0.60
HTRA2	interacts_with	gene	0.60
MTOR	interacts_with	gene	0.60
SIRT3	interacts_with	gene	0.60
PLIN2	interacts_with	gene	0.60
TP53	interacts_with	gene	0.60
SIRT1	interacts_with	gene	0.60
STX17	interacts_with	gene	0.60
STING1	interacts_with	gene	0.60
GLP1R	interacts_with	gene	0.60
SREBF1	interacts_with	gene	0.60
NOS3	interacts_with	gene	0.60
TFEB	activates	gene	0.60
ULK1	activates	gene	0.60
FGF21	activates	gene	0.60
PPARA	interacts_with	gene	0.60
TFEB	interacts_with	gene	0.60
LAMP2	activates	entity	0.60
MAP3K5	activates	entity	0.60
MTOR	activates	entity	0.60
NFE2L2	activates	entity	0.60
NOS3	activates	entity	0.60
NR1H3	activates	entity	0.60
P62	activates	entity	0.60
PLIN2	activates	entity	0.60
PLIN3	activates	entity	0.60
PPARA	activates	entity	0.60
PRKAA2	activates	entity	0.60

Incoming (77)

Source	Relation	Type	Str
TAU	interacts_with	protein	0.65
FGF21	activates	gene	0.60
ULK1	activates	gene	0.60
PPARA	interacts_with	gene	0.60
ULK1	interacts_with	gene	0.60
STX17	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
NOS3	interacts_with	gene	0.60
STING1	interacts_with	gene	0.60
GLP1R	interacts_with	gene	0.60
SREBF1	interacts_with	gene	0.60
SIRT1	interacts_with	gene	0.60
TFEB	activates	gene	0.60
ATG7	activates	gene	0.60
FOXO1	interacts_with	gene	0.60
TFEB	interacts_with	gene	0.60
MTOR	interacts_with	gene	0.60
P62	interacts_with	gene	0.60
NR1H3	interacts_with	gene	0.60
MAP3K5	interacts_with	gene	0.60
LAMP2	interacts_with	gene	0.60
BECN1	interacts_with	gene	0.60
RPTOR	interacts_with	gene	0.60
HTRA2	interacts_with	gene	0.60
PRKAA2	interacts_with	gene	0.60
GRK2	interacts_with	gene	0.60
LC3	activates	gene	0.60
PLIN3	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60
TP53	interacts_with	gene	0.60
SIRT3	interacts_with	gene	0.60
PLIN2	interacts_with	gene	0.60
SREBF2	interacts_with	gene	0.60
C1Q	interacts_with	gene	0.60
NFE2L2	interacts_with	gene	0.60
BECN1	activates	entity	0.60
C1Q	activates	entity	0.60
FOXO1	activates	entity	0.60
GLP1R	activates	entity	0.60
GRK2	activates	entity	0.60
HTRA2	activates	entity	0.60
SLC17A7	activates	gene	0.60
VGLUT2	expressed_in	gene	0.60
VGLUT1	activates	gene	0.60
TAU	activates	gene	0.60
ADIPOQ	activates	gene	0.60
CREBBP	interacts_with	gene	0.60
EP300	interacts_with	gene	0.60
GAPDH	interacts_with	gene	0.60
HSP90AB1	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

KDM6B

Understanding Entity Pages

Summary

Wiki Pages (21)

KDM6B (JMJD3)

Epigenetic Dysregulation in Neurodegeneration

setd1a

KDM4B (Lysine Demethylase 4B)

Median Eminence Tanycytes

Subthalamic Nucleus Glutamatergic Neurons

KDM6A Gene

PHF8 (PHD Finger Protein 8)

Alzheimer's Disease Histone Methylation and Epigenetic Writer Companies

KDM7A

KDM5C (Lysine Demethylase 5C)

Arcuate Nucleus of Medulla

KDM5B (Lysine Demethylase 5B)

NSD2 (Nuclear Receptor Binding SET Domain Protein 2)

JARID2

EED

SUZ12

Medial Terminal Nucleus Neurons

Pre-Bötzinger Complex Expanded v2