protein

TUBULIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TUBULIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

550Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

TUBULIN is a protein involved in neurodegeneration research. Key relationships include: associated with, activates, regulates. Associated with ALS, Alzheimer, Inflammation. Connected to 136 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	TUBULIN
Protein Family	Tubulin family
Function	is a protein encoded by the TUBB gene.
Subcellular Localization	Microtubules, cytoplasm
Molecular Weight	55 kDa
Amino Acids	4477 aa
Pathways	Autophagy, Phagocytosis, Proteasome, Ubiquitin-Proteasome
UniProt ID	P07437
GeneCards	TUBULIN
Human Protein Atlas	TUBULIN
GTP-binding domain	α-Tubulin binds GTP at its N-terminal domain (though the GTP is not hydrolyzed)
Heterodimer formation	α-Tubulin binds β-Tubulin to form α/β heterodimers, the basic subunit of microtubules
C-terminal tail	The acidic C-terminal tail interacts with microtubule-associated proteins (MAPs)
Anterograde transport	Kinesin motors carry vesicles, proteins, organelles toward synaptic terminals
Retrograde transport	Dynein motors return materials to the cell body
Associated Diseases	Als, Amyotrophic Lateral Sclerosis, Ms, Pyroptosis
Interactions	JUN, ACTB, ATG7, TAU, ELAVL3, GFAP
KG Connections	426 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: TUBULIN — AlphaFold P07437 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    TUBULIN["TUBULIN"]
    TUBULIN -->|"activates"| Ischemia["Ischemia"]
    TUBULIN -->|"activates"| Neurodegeneration["Neurodegeneration"]
    TUBULIN -->|"activates"| Alzheimer["Alzheimer"]
    TUBULIN -.biomarker for.-> Neuroinflammation["Neuroinflammation"]
    TUBULIN -.biomarker for.-> Inflammation["Inflammation"]
    TUBULIN -->|"activates"| ALS["ALS"]
    TUBULIN -->|"regulates"| LYSOSOME["LYSOSOME"]
    TUBULIN -->|"regulates"| GJA1["GJA1"]
    TAU["TAU"] -->|"interacts"| TUBULIN
    ROS["ROS"] -->|"activates"| TUBULIN
    AXON["AXON"] -->|"activates"| TUBULIN
    APOPTOSIS["APOPTOSIS"] -->|"activates"| TUBULIN
    OXIDATIVE_STRESS["OXIDATIVE STRESS"] -->|"activates"| TUBULIN

Outgoing (299)

Target	Relation	Type	Str
Ischemia	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Alzheimer	activates	disease	0.65
Neuroinflammation	biomarker_for	disease	0.65
Inflammation	biomarker_for	disease	0.65
Neurodegeneration	biomarker_for	disease	0.65
ALS	activates	disease	0.65
Inflammation	activates	disease	0.65
Alzheimer	inhibits	disease	0.65
Neuroinflammation	inhibits	disease	0.65
Ms	activates	disease	0.65
Ms	inhibits	disease	0.65
Parkinson	inhibits	disease	0.65
Neurodegeneration	inhibits	disease	0.65
Ms	associated_with	disease	0.65
Als	causes	disease	0.65
Amyotrophic Lateral Sclerosis	associated_with	disease	0.65
Neuropathy	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
Als	expressed_in	disease	0.65
Multiple Sclerosis	inhibits	disease	0.65
Alzheimer	regulates	disease	0.65
Als	regulates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Als	activates	disease	0.65
Aging	activates	disease	0.65
Alzheimer	protects_against	disease	0.65
ALS	inhibits	disease	0.65
ALS	expressed_in	disease	0.65
ALS	regulates	disease	0.65
Inflammation	regulates	disease	0.65
Pyroptosis	causes	disease	0.65
Alzheimer	stabilizes	disease	0.65
Als	stabilizes	disease	0.65
Parkinson	regulates	disease	0.65
UBIQUITIN	activates	entity	0.60
UVRAG	activates	entity	0.60
VIM	activates	entity	0.60
VIMENTIN	activates	entity	0.60
P62	associated_with	gene	0.60
MAP3K5	associated_with	gene	0.60
UBIQUITIN	associated_with	gene	0.60
OCLN	associated_with	gene	0.60
GJA1	regulates	gene	0.60
SQSTM1	associated_with	gene	0.60
CASP3	regulates	gene	0.60
GAPDH	regulates	gene	0.60
ACTB	regulates	gene	0.60
TUBB3	associated_with	gene	0.60
UVRAG	associated_with	gene	0.60

Incoming (251)

Source	Relation	Type	Str
MAPT	interacts_with	protein	0.90
TAU	interacts_with	protein	0.72
HDAC6	phosphorylates	entity	0.60
LAMP1	activates	entity	0.60
MAP1LC3B	activates	entity	0.60
MAP3K5	activates	entity	0.60
OCLN	activates	entity	0.60
P62	activates	entity	0.60
PIK3C3	activates	entity	0.60
RAC1	activates	entity	0.60
SQSTM1	activates	entity	0.60
STK11	activates	entity	0.60
TUBB3	activates	entity	0.60
MAP2	activates	entity	0.60
MTOR	activates	entity	0.60
SNAP25	activates	entity	0.60
SYN1	activates	entity	0.60
SYT1	activates	entity	0.60
TFEB	activates	entity	0.60
ELAVL3	regulates	entity	0.60
GAP43	regulates	entity	0.60
GFAP	regulates	entity	0.60
MANF	regulates	entity	0.60
MBP	regulates	entity	0.60
MTOR	associated_with	gene	0.60
P62	associated_with	gene	0.60
MAP1LC3B	associated_with	gene	0.60
TUBB3	associated_with	gene	0.60
VIM	associated_with	gene	0.60
H2AX	regulates	gene	0.60
PIK3C3	associated_with	gene	0.60
UVRAG	associated_with	gene	0.60
STK11	associated_with	gene	0.60
OCLN	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
ACTB	regulates	gene	0.60
GJA1	regulates	gene	0.60
RAC1	associated_with	gene	0.60
CDC42	regulates	gene	0.60
GAPDH	regulates	gene	0.60
LAMP1	associated_with	gene	0.60
HDAC6	regulates	gene	0.60
BECN1	regulates	gene	0.60
CTSD	associated_with	gene	0.60
LC3	associated_with	gene	0.60
ATG7	activates	gene	0.60
SYN1	associated_with	gene	0.60
SYT1	associated_with	gene	0.60
JUN	activates	gene	0.60
ACTB	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

TUBULIN

Understanding Entity Pages

Summary

Wiki Pages (21)

α-Tubulin (Alpha-Tubulin)

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Novel Therapy Index

Alpha-Synuclein Pathology

Multiple System Atrophy

Axonal Transport Dysfunction Comparison Across Neurodegenerative Diseases

nf1-protein

Epigenetic Dysregulation in Neurodegeneration

KARS1

Tauopathies

LRRK2 G2019S

DCTN1 Protein (Dynactin Subunit 1)

tau-hyperphosphorylation

msa-pathophysiology-disease-mechanisms

Kv7.2 Potassium Channel

Epigenetic Mechanisms in Alzheimer's Disease

CNTFR Gene

Tunneling Nanotubes in Neurodegeneration

HDAC6 Protein