protein

MBP

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MBP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

378Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

MBP is a protein involved in neurodegeneration research. Key relationships include: activates, expressed in, inhibits. Associated with ALS, Aging, Als. Connected to 174 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	MBP
Full Name	Myelin Basic Protein
Chromosome	18q23
Function	Membrane compaction: MBP interacts with the cytoplasmic surface of the oligodendrocyte membrane, facilitating the tight apposition of myelin lamellae [6]
Primary Expression	a developmentally regulated manner, with different isoforms predominant at different stages of oligodendrocyte maturation and myelination
Molecular Weight	18.5-21.5 kDa (various isoforms)
Amino Acids	197 aa
Exons	11
Pathways	MAPK
Ensembl ID	ENSG00000197971
GeneCards	MBP
Human Protein Atlas	MBP
Gene	MBP (Myelin Basic Protein), located on chromosome 18q23
Protein	170-185 amino acids (multiple isoforms via alternative splicing)
Exon 2-containing	21.5 kDa (early development)
Associated Diseases	ALS, Alzheimer, Ms, Parkinson, dementia
Known Drugs/Compounds	metformin
Interactions	PLP1, MANF, GAP43, ELAVL3, GFAP, ATF3
KG Connections	377 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    MBP["MBP"]
    MBP -->|"activates"| Dementia["Dementia"]
    MBP -->|"activates"| Als["Als"]
    MBP -->|"activates"| Alzheimer["Alzheimer"]
    MBP -->|"activates"| Parkinson["Parkinson"]
    MBP -->|"activates"| Ms["Ms"]
    MBP -->|"activates"| Inflammation["Inflammation"]
    MBP -->|"regulates"| Stroke["Stroke"]
    MBP -->|"regulates"| Neuroinflammation["Neuroinflammation"]
    MBP -->|"regulates"| Traumatic_Brain_Injury["Traumatic Brain Injury"]
    HSPA1A["HSPA1A"] -->|"activates"| MBP
    GFAP["GFAP"] -->|"inhibits"| MBP
    GAP43["GAP43"] -->|"inhibits"| MBP
    ELAVL3["ELAVL3"] -->|"inhibits"| MBP
    MANF["MANF"] -->|"inhibits"| MBP
    P38["P38"] -->|"regulates"| MBP
    CD36["CD36"] -->|"activates"| MBP
    TNF["TNF"] -->|"regulates"| MBP
    ACHE["ACHE"] -->|"activates"| MBP
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"expressed in"| MBP

Outgoing (237)

Target	Relation	Type	Str
ds-f2c28aed24a7	provides_data_for	dataset	1.00
Myelin Degeneration	biomarker_for	phenotype	0.87
Hypermyelination	involved_in	phenotype	0.85
Inflammation	activates	disease	0.85
Als	expressed_in	disease	0.85
Microglia	upregulates	cell_type	0.85
Parkinson's Disease Dementia	upregulates	disease	0.80
oligodendrocytes	expressed_in	cell_type	0.80
oxidative stress response	participates_in	pathway	0.80
Oxidative Stress	activates	pathway	0.70
Apoptosis	activates	pathway	0.70
AUTOPHAGY	expressed_in	gene	0.70
Autophagy	expressed_in	pathway	0.70
MICROGLIA	activates	cell_type	0.70
MOG	associated_with	gene	0.65
PLP1	associated_with	gene	0.65
MOG	regulates	gene	0.65
MTOR	co_discussed	gene	0.65
OLIG2	co_discussed	gene	0.65
PARP1	co_discussed	gene	0.65
oligodendrocyte	co_discussed	concept	0.65
neuron	co_discussed	concept	0.65
Dementia	activates	disease	0.65
Als	activates	disease	0.65
Alzheimer	activates	disease	0.65
Parkinson	activates	disease	0.65
Ms	associated_with	disease	0.65
Ms	activates	disease	0.65
Stroke	regulates	disease	0.65
Neuroinflammation	regulates	disease	0.65
Traumatic Brain Injury	regulates	disease	0.65
Inflammation	regulates	disease	0.65
Ms	regulates	disease	0.65
OLIGODENDROCYTE	associated_with	concept	0.65
Alzheimer	expressed_in	disease	0.65
Dementia	expressed_in	disease	0.65
Ms	inhibits	disease	0.65
Tumor	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Schizophrenia	expressed_in	disease	0.65
Bipolar	expressed_in	disease	0.65
Depression	expressed_in	disease	0.65
Als	associated_with	disease	0.65
ALS	activates	disease	0.65
Tumor	expressed_in	disease	0.65
Aging	inhibits	disease	0.65
Neurodegeneration	expressed_in	disease	0.65
Multiple Sclerosis	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Tumor	inhibits	disease	0.65

Incoming (141)

Source	Relation	Type	Str
ds-f2c28aed24a7	data_in	dataset	1.00
Bpmc	downregulates	compound	0.85
Transcranial near-infrared light	upregulates	compound	0.85
OLEA	upregulates	compound	0.80
MYELIN	activates	gene	0.80
INFLAMMATION	activates	gene	0.80
TNF	activates	gene	0.70
GENES	activates	gene	0.70
APOPTOSIS	activates	gene	0.70
OXIDATIVE STRESS	activates	gene	0.70
OLIGODENDROCYTE	activates	gene	0.70
APOE	co_discussed	gene	0.65
LRRK2	co_discussed	gene	0.65
CLU	co_discussed	gene	0.65
BIN1	co_discussed	gene	0.65
DEMYELINATION	regulates	phenotype	0.65
HSPA1A	activates	gene	0.60
GFAP	inhibits	gene	0.60
GAP43	inhibits	gene	0.60
ELAVL3	inhibits	gene	0.60
MANF	inhibits	gene	0.60
P38	regulates	gene	0.60
CD36	activates	gene	0.60
TNF	regulates	gene	0.60
GFAP	co_discussed	gene	0.60
MMP9	associated_with	gene	0.60
RELA	expressed_in	gene	0.60
OPA1	associated_with	gene	0.60
P62	expressed_in	gene	0.60
MFN2	associated_with	gene	0.60
BAX	activates	gene	0.60
PLP1	activates	gene	0.60
SOX10	expressed_in	gene	0.60
DISC1	inhibits	gene	0.60
IL1B	interacts_with	gene	0.60
SOD2	interacts_with	gene	0.60
MARCKS	associated_with	gene	0.60
LAMP1	interacts_with	gene	0.60
TUBULIN	inhibits	gene	0.60
IBA1	activates	gene	0.60
BDNF	activates	gene	0.60
ACSL4	inhibits	gene	0.60
STAT3	implicated_in	gene	0.60
IL6	activates	gene	0.60
FER	activates	gene	0.60
MOG	activates	gene	0.60
ELAVL3	regulates	entity	0.60
GAP43	regulates	entity	0.60
GFAP	regulates	entity	0.60
MANF	regulates	entity	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

MBP

Understanding Entity Pages

Summary

Wiki Pages (21)

Myelin Basic Protein (MBP) - Biomarker

Progressive Supranuclear Palsy (PSP)

Novel Therapy Index

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

Corticobasal Degeneration (CBD)

Oligodendrocytes

rankings

Glia-Neuron Crosstalk in Alzheimer's Disease

KARS1

Section 233: Advanced Virtual Reality and Immersive Technology-Based Rehabilitation in CBS/PSP

Thyroid Hormone Signaling Pathway in Neurodegeneration

Multiple Sclerosis (MS)

Oligodendrocyte and Myelin Dysfunction in Corticobasal Syndrome

TGF-β Signaling in Parkinson's Disease

msa-pathophysiology-disease-mechanisms

Remyelination in Neurodegeneration

FA2H Gene

Viral Vector Delivery Investment Landscape for Neurodegeneration

Section 249: Advanced LSVT Voice and Speech Therapy in CBS/PSP