gene

MANF

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MANF: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

152Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

MANF (Mesencephalic Astrocyte-Derived Neurotrophic Factor) gene encoding a neurotrophic factor with ER stress modulation properties, implicated in Parkinson's disease, Alzheimer's disease, and stroke

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🧬 Gene Info

Gene Symbol	MANF
Aliases	Mesencephalic Astrocyte-Derived Neurotrophic Factor
Function	encodes a unique neurotrophic factor with distinctive mechanisms of action distinct from classical neurotrophic factors like BDNF or GDNF.
Molecular Weight	20 kDa
Amino Acids	182 aa
Exons	4
Pathways	Amyloid, Immune Response, Lipid Metabolism, Mitophagy, Oxidative Stress
Ensembl ID	ENSG00000131791
GeneCards	MANF
Human Protein Atlas	MANF
Exon 1	Encodes the signal peptide and N-terminal portion
Exon 2-4	Encode the C-terminal secreted domain with cysteine-rich regions
Associated Diseases	PRKN E3 ligase activity, breast cancer cell survival
Interactions	MBP, GAP43, ELAVL3, GFAP, TUBULIN, Tubulin
KG Connections	152 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (19)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    MANF["<b>MANF</b>"]
    breast_cancer_cell_survival["breast cancer cell survival"]
    MANF -->|"associated with"| breast_cancer_cell_survival
    mitophagy(["mitophagy"])
    MANF -->|"activates"| mitophagy
    PRKN["PRKN"]
    MANF -->|"interacts with"| PRKN
    PRKN_E3_ligase_activity["PRKN E3 ligase activity"]
    MANF -->|"associated with"| PRKN_E3_ligase_activity
    fatty_acid_oxidation(["fatty acid oxidation"])
    MANF -->|"associated with"| fatty_acid_oxidation
    PARK2["PARK2"]
    MANF -->|"binds"| PARK2
    Als{"Als"}
    MANF -->|"activates"| Als
    Ms{"Ms"}
    MANF -->|"activates"| Ms
    Inflammation{"Inflammation"}
    MANF -->|"activates"| Inflammation
    Cancer{"Cancer"}
    MANF -->|"regulates"| Cancer
    Tumor{"Tumor"}
    MANF -->|"interacts with"| Tumor
    ALS{"ALS"}
    MANF -->|"activates"| ALS
    SENP1["SENP1"]
    SENP1 -->|"modifies"| MANF
    GFAP["GFAP"]
    GFAP -->|"inhibits"| MANF
    GAP43["GAP43"]
    GAP43 -->|"inhibits"| MANF
    ELAVL3["ELAVL3"]
    ELAVL3 -->|"inhibits"| MANF
    MBP["MBP"]
    MBP -->|"inhibits"| MANF
    GENES["GENES"]
    GENES -->|"inhibits"| MANF
    ACHE["ACHE"]
    ACHE -->|"activates"| MANF
    CAT["CAT"]
    CAT -->|"biomarker for"| MANF
    FERROPTOSIS["FERROPTOSIS"]
    FERROPTOSIS -->|"activates"| MANF
    OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    OXIDATIVE_STRESS -->|"biomarker for"| MANF
    GPX4["GPX4"]
    GPX4 -->|"biomarker for"| MANF
    ATF4["ATF4"]
    ATF4 -->|"activates"| MANF
    style MANF fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (102)

Target	Relation	Type	Str
PRKN	binds_to	protein	0.95
mitophagy	promotes	process	0.95
breast cancer cell survival	associated_with	phenotype	0.90
PRKN	interacts_with	gene	0.90
PRKN E3 ligase activity	associated_with	phenotype	0.90
PRKN	activates	protein	0.90
breast cancer	therapeutic_target	disease	0.90
mitophagy	activates	pathway	0.90
fatty acid oxidation	promotes	process	0.85
fatty acid oxidation	associated_with	pathway	0.80
PARK2	binds	gene	0.80
NEURON	expressed_in	cell_type	0.80
Oxidative Stress	regulates	pathway	0.70
Als	activates	disease	0.65
Ms	activates	disease	0.65
Inflammation	activates	disease	0.65
Cancer	regulates	disease	0.65
Tumor	interacts_with	disease	0.65
ALS	activates	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Neuroinflammation	therapeutic_target	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Neurodegeneration	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
Neuroinflammation	regulates	disease	0.65
Inflammation	regulates	disease	0.65
MBP	inhibits	gene	0.60
GAP43	inhibits	gene	0.60
ELAVL3	inhibits	gene	0.60
GFAP	inhibits	gene	0.60
MBP	regulates	entity	0.60
TUBULIN	regulates	entity	0.60
Tubulin	inhibits	protein	0.60
Rb	activates	protein	0.60
TAU	therapeutic_target	gene	0.60
neuroinflammation	activates	disease	0.60
neuroinflammation	regulates	disease	0.60
TFEB	regulates	gene	0.60
Oxidative Stress	activates	pathway	0.60
Apoptosis	activates	pathway	0.60
ACHE	activates	gene	0.60
Ferroptosis	activates	pathway	0.60
Er Stress	activates	pathway	0.60
Oxidative Stress	biomarker_for	pathway	0.60
Mitophagy	regulates	pathway	0.60
INFLAMMATION	activates	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
AMYLOID	therapeutic_target	gene	0.60

Incoming (50)

Source	Relation	Type	Str
SENP1	de-SUMOylates	protein	0.90
Bpmc	downregulates	compound	0.85
SENP1	modulates	protein	0.85
SENP1	modifies	protein	0.80
OXIDATIVE STRESS	regulates	gene	0.70
GFAP	inhibits	gene	0.60
GAP43	inhibits	gene	0.60
ELAVL3	inhibits	gene	0.60
MBP	inhibits	gene	0.60
CAT	biomarker_for	gene	0.60
GPX4	biomarker_for	gene	0.60
ATF4	activates	gene	0.60
SENP1	activates	gene	0.60
PARKIN	regulates	gene	0.60
UBIQUITIN	regulates	gene	0.60
PRKN	regulates	gene	0.60
TUBULIN	inhibits	gene	0.60
TAU	therapeutic_target	gene	0.60
ELAVL3	regulates	entity	0.60
GAP43	regulates	entity	0.60
GFAP	regulates	entity	0.60
GENES	inhibits	gene	0.60
ACHE	activates	gene	0.60
FERROPTOSIS	activates	gene	0.60
OXIDATIVE STRESS	biomarker_for	gene	0.60
MITOPHAGY	regulates	gene	0.60
CANCER	regulates	gene	0.60
ROS	activates	gene	0.60
AXON	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
NEURON	activates	gene	0.60
MYELIN	activates	gene	0.60
INFLAMMATION	activates	gene	0.60
NEUROTOXICITY	activates	gene	0.60
NEURODEGENERATION	therapeutic_target	gene	0.60
EXERCISE	therapeutic_target	gene	0.60
SYN2A	inhibits	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
EXERCISE	regulates	gene	0.60
NEUROINFLAMMATION	regulates	gene	0.60
MITOCHONDRIAL DYSFUNCTION	regulates	gene	0.60
ASTROCYTE	regulates	gene	0.60
ALZHEIMER	regulates	gene	0.60
FGF	regulates	gene	0.60
BPMC	inhibits	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
ALZHEIMER	activates	gene	0.50
AMYLOID	co_discussed	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

MANF

Understanding Entity Pages

Summary

Wiki Pages (19)

MANF Gene

Neurotrophic Factors in Neurodegeneration

Section 103: Neurotrophic Factor Therapies in CBS/PSP

Wolfram Syndrome

Spinocerebellar Ataxia Type 17 (SCA17)

CDNF Gene

Section 141: Advanced Neurotrophin and Growth Factor Therapy in CBS/PSP

Neurotrophic Factor Gene Therapy Programs — GDNF, CDNF, BDNF, Neurturin

Cerebral Dopamine Neurotrophic Factor

Parkin Protein

PRKN — Parkin RBR E3 Ubiquitin Protein Ligase

ELAVL3 Gene

Neurotrophic Factor Therapy for Neurodegenerative Diseases

MDS 2026: Advanced Therapies and Disease Modification in Movement Disorders

Peptide-Based Therapeutics for Neurodegeneration

SENP1 — SUMO Specific Peptidase 1

MANF Protein