gene

CASP6

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CASP6: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

60Connections

0Hypotheses

0Analyses

37Outgoing

23Incoming

Summary

CASP6 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, implicated in. Associated with Als, Cancer, Ms. Connected to 10 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	CASP6
Full Name	Caspase-6
Chromosome	4q25
Protein Type	Enzyme
Function	Initiator caspase cleavage: Caspase-1 or caspase-3 cleave procaspase-6 at Asp179 and Asp193
Primary Expression	Brain (hippocampus, cortex, striatum), ubiquitous
Amino Acids	293 aa
Exons	7
Pathways	Apoptosis, Neurodegeneration
UniProt ID	P55212
NCBI Gene ID	839
Ensembl ID	ENSG00000138794
OMIM	601532
GeneCards	CASP6
Human Protein Atlas	CASP6
Associated Diseases	Aging, Alzheimer, Alzheimer Disease, Dementia, Huntington Disease, Pyroptosis
Interactions	DES, RIPK1, FADD, CEBPB, MCL1, MDM2
KG Connections	60 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CASP6 — AlphaFold P55212 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (14)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    CASP6["<b>CASP6</b>"]
    Als{"Als"}
    CASP6 -->|"interacts with"| Als
    Ms{"Ms"}
    CASP6 -->|"interacts with"| Ms
    Cancer{"Cancer"}
    CASP6 -->|"interacts with"| Cancer
    DES["DES"]
    CASP6 -->|"interacts with"| DES
    CANCER["CANCER"]
    CASP6 -->|"interacts with"| CANCER
    RIPK1["RIPK1"]
    CASP6 -->|"interacts with"| RIPK1
    FADD["FADD"]
    CASP6 -->|"interacts with"| FADD
    neurodegeneration["neurodegeneration"]
    CASP6 -->|"implicated in"| neurodegeneration
    FAS["FAS"]
    FAS -->|"interacts with"| CASP6
    CASP8["CASP8"]
    CASP8 -->|"interacts with"| CASP6
    style CASP6 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (37)

Target	Relation	Type	Str
Neurodegeneration	involved_in	process	0.90
Huntington Disease	associated_with	disease	0.85
Alzheimer Disease	associated_with	disease	0.85
Post Mortem Brain	expressed_in	cell_type	0.80
Als	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Cancer	interacts_with	disease	0.65
Pyroptosis	associated_with	disease	0.65
Dementia	associated_with	disease	0.65
Alzheimer	associated_with	disease	0.65
Aging	associated_with	disease	0.65
DES	interacts_with	gene	0.60
RIPK1	interacts_with	gene	0.60
FADD	interacts_with	gene	0.60
PYCARD	associated_with	gene	0.60
BAX	associated_with	gene	0.60
CASP4	associated_with	gene	0.60
NLRP6	associated_with	gene	0.60
NLRP3	associated_with	gene	0.60
PYCARD	expressed_in	gene	0.60
CEBPB	activates	gene	0.60
MCL1	activates	gene	0.60
MDM2	activates	gene	0.60
TNF	activates	gene	0.60
CANCER	interacts_with	gene	0.60
DEMENTIA	associated_with	gene	0.60
Monocyte	associated_with	cell_type	0.60
IMMUNE INFILTRATION	associated_with	gene	0.60
PYROPTOSIS	associated_with	gene	0.60
pyroptosis	participates_in	pathway	0.60
pyroptosis	expressed_in	process	0.60
NF-kB signaling	participates_in	pathway	0.60
oxidative stress response	participates_in	pathway	0.60
NLRP6	expressed_in	gene	0.50
CASP4	expressed_in	protein	0.50
NLRP3	expressed_in	protein	0.50
Pyroptosis	expressed_in	pathway	0.50

Incoming (23)

Source	Relation	Type	Str
FAS	interacts_with	gene	0.60
CASP8	interacts_with	gene	0.60
NLRP6	associated_with	gene	0.60
NLRP3	associated_with	gene	0.60
CASP4	associated_with	gene	0.60
PYCARD	associated_with	gene	0.60
BAX	associated_with	gene	0.60
BAX	expressed_in	gene	0.60
CASP4	expressed_in	gene	0.60
BCL2A1	activates	gene	0.60
CASP3	activates	gene	0.60
PYROPTOSIS	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
AGING	associated_with	gene	0.60
DEMENTIA	associated_with	gene	0.60
GENES	associated_with	gene	0.60
AND	associated_with	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
BAX	co_discussed	gene	0.50
CASP4	co_discussed	protein	0.50
PYCARD	expressed_in	gene	0.50
ALZHEIMER	activates	gene	0.50
DEMENTIA	activates	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

CASP6

Understanding Entity Pages

Summary

Wiki Pages (14)

CASP6 — Caspase-6

Cell Death Pathways in 4R-Tauopathies

casp8

CASP14 Gene

casp3

CASP2 Gene

Caspase-6

Mutant Huntingtin (mHTT) Clearance Mechanisms — Therapeutic Target Validation

Protein Families & Clusters

BCL2A1 Gene

CASP3 Protein — Caspase-3

Caspase 2 (CASP2)