protein

CLAUDIN-5

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CLAUDIN-5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

60Connections

0Hypotheses

0Analyses

44Outgoing

13Incoming

Summary

Page for Claudin-5 Protein

View on Wiki →

🔬 Protein Info

Gene Symbol	CLAUDIN
Molecular Weight	21.8 kDa
Amino Acids	218 aa
Pathways	Endocytosis
GeneCards	CLAUDIN
Human Protein Atlas	CLAUDIN
Interactions	IL-1Β, NF-ΚB, NLRP3, OCCLUDIN, Proteins, ALZHEIMER
KG Connections	57 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    CLAUDIN_5["<b>CLAUDIN-5</b>"]
    GFAP(["GFAP"])
    CLAUDIN_5 -->|"co_discussed"| GFAP
    IL_1_(["IL-1Beta"])
    CLAUDIN_5 -->|"activates"| IL_1_
    NEURON(["NEURON"])
    CLAUDIN_5 -->|"co_discussed"| NEURON
    NF__B(["NF-KappaB"])
    CLAUDIN_5 -->|"activates"| NF__B
    NLRP3(["NLRP3"])
    CLAUDIN_5 -->|"activates"| NLRP3
    OCLN(["OCLN"])
    CLAUDIN_5 -->|"co_discussed"| OCLN
    ALZHEIMER(["ALZHEIMER"])
    ALZHEIMER -->|"co_discussed"| CLAUDIN_5
    AQP4(["AQP4"])
    AQP4 -->|"co_discussed"| CLAUDIN_5
    APP(["APP"])
    APP -->|"activates"| CLAUDIN_5
    style CLAUDIN_5 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#4fc3f7

Outgoing (45)

Target	Relation	Type	Str
GFAP	co_discussed	gene	0.50
IL-1Β	activates	protein	0.50
NEURON	co_discussed	gene	0.50
NF-ΚB	activates	gene	0.50
NLRP3	activates	protein	0.50
OCLN	co_discussed	gene	0.50
PARKIN	co_discussed	gene	0.50
PARKINSON	co_discussed	gene	0.50
SNCA	expressed_in	gene	0.50
WAS	co_discussed	protein	0.50
GENES	co_discussed	gene	0.50
LRP1	co_discussed	gene	0.50
OCCLUDIN	co_discussed	protein	0.50
STROKE	co_discussed	gene	0.50
OCCLUDIN	expressed_in	protein	0.50
CAVEOLIN-1	regulates	protein	0.50
Endocytosis	regulates	pathway	0.50
Endothelial Cell	regulates	cell_type	0.50
ENDOTHELIAL	regulates	concept	0.50
ISCHEMIC	regulates	concept	0.50
ISCHEMIC STROKE	regulates	concept	0.50
ENDOTHELIAL CELLS	regulates	concept	0.50
STEM CELLS	regulates	concept	0.50
EXTRACELLULAR VESICLES	regulates	concept	0.50
OCCLUDIN	activates	protein	0.50
EXERCISE	activates	concept	0.50
EXOSOMES	activates	concept	0.50
ENDOTHELIAL	activates	concept	0.50
CELL PROLIFERATION	activates	concept	0.50
PERICYTES	activates	concept	0.50
ENDOTHELIAL CELLS	activates	concept	0.50
OCCLUDIN	inhibits	protein	0.50
Hippocampus	inhibits	entity	0.50
GENE EXPRESSION	inhibits	concept	0.50
Spinal Cord	activates	cell_type	0.50
Proteins	activates	protein	0.50
Proteins	expressed_in	protein	0.50
OCCLUDIN	associated_with	protein	0.50
Proteins	associated_with	protein	0.50
apoptosis	associated_with	process	0.50
NF-κB	associated_with	concept	0.50
CYTOKINES	associated_with	concept	0.50
Reactive Oxygen Species	associated_with	process	0.50
CELL PROLIFERATION	associated_with	concept	0.50

Incoming (15)

Source	Relation	Type	Str
ALZHEIMER	co_discussed	gene	0.50
AQP4	co_discussed	gene	0.50
ALZHEIMER	activates	gene	0.50
APP	activates	gene	0.50
STROKE	regulates	gene	0.50
PHAGOCYTOSIS	activates	gene	0.50
LRP1	activates	gene	0.50
TDP43	activates	protein	0.50
GFAP	activates	gene	0.50
AQP4	associated_with	gene	0.50
AQUAPORIN-4	associated_with	gene	0.50
OCLN	associated_with	gene	0.50
GFAP	associated_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

CLAUDIN-5

Understanding Entity Pages

Summary

Wiki Pages (20)

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Blood-Brain Barrier Biology and Crossing Strategies

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Traumatic Brain Injury and Neurodegeneration Pathway

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Gut-Brain Axis in Neurodegeneration

Psychobiotic Therapy for Neurodegenerative Diseases

neurovascular-dysfunction

cGMP Signaling Pathway in Neurodegeneration

Neuroinflammation in Amyotrophic Lateral Sclerosis

bbb-transport-mechanisms

vegfr-signaling-neurodegeneration

Blood-Brain Barrier Breakdown in Neurodegeneration

Cerebral Ischemia Pathway in Neurodegeneration

blood-brain-barrier-endothelial-cells

Receptor-Mediated Transcytosis (RMT)