concept

PERICYTES

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PERICYTES: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

247Connections

0Hypotheses

1Analyses

31Outgoing

50Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	PERICYTES
Summary	Pericytes are specialized mural cells that maintain blood-brain barrier integrity and regulate cerebral blood flow. Their dysfunction contributes to neurodegenerative diseases.
Key Genes/Proteins	VEGF
Related Diseases	ALZHEIMER

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    PERICYTES["PERICYTES"]
    style PERICYTES fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    PERICYTES -->|"component_of"| Neurovascular_Unit["Neurovascular Unit"]
    PERICYTES -->|"involved_in"| Blood_Brain_Barrier["Blood-Brain Barrier"]
    PERICYTES -->|"regulates"| SENESCENCE["SENESCENCE"]
    PERICYTES -->|"activates"| VEGF([VEGF])
    SMAD3([SMAD3]) -->|"expressed in"| PERICYTES
    KATP([KATP]) -->|"expressed in"| PERICYTES
    PERICYTE["/PERICYTE/"] -->|"causes"| PERICYTES
    AUTOPHAGY["AUTOPHAGY"] -->|"regulates"| PERICYTES
    ASTROCYTE["/ASTROCYTE/"] -->|"activates"| PERICYTES
    ASTROCYTES["/ASTROCYTES/"] -->|"activates"| PERICYTES
    ENDOTHELIAL["/ENDOTHELIAL/"] -->|"contributes to"| PERICYTES

Outgoing (41)

Target	Relation	Type	Str
vascular barrier function	promotes	process	0.90
VEGF	activates	gene	0.65
VEGF	inhibits	gene	0.60
ENDOTHELIAL CELLS	produces	cell_type	0.60
T CELL	co_discussed	entity	0.50
T CELLS	co_discussed	entity	0.50
STING	co_discussed	entity	0.50
PRION-LIKE	co_discussed	entity	0.50
ENDOTHELIAL CELLS	associated_with	concept	0.50
EXTRACELLULAR VESICLES	associated_with	concept	0.50
FIBROBLASTS	associated_with	concept	0.50
B CELLS	associated_with	concept	0.50
EXTRACELLULAR MATRIX	associated_with	concept	0.50
ENDOTHELIAL CELLS	activates	concept	0.50
IPSC	activates	concept	0.50
CENTRAL NERVOUS SYSTEM	activates	concept	0.50
ENDOTHELIAL CELLS	inhibits	concept	0.50
CENTRAL NERVOUS SYSTEM	regulates	concept	0.50
FIBROBLASTS	activates	concept	0.50
ENDOTHELIAL CELLS	interacts_with	concept	0.50
VEGF	co_discussed	gene	0.40
SEPSIS	regulates	disease	0.35
PI3K	regulates	gene	0.35
TAU	regulates	protein	0.35
T CELLS	interacts_with	cell_type	0.35
STEM CELLS	activates	cell_type	0.35
SENESCENCE	activates	process	0.35
SENESCENCE	associated_with	process	0.35
SENESCENCE	implicated_in	process	0.35
RAPAMYCIN	activates	drug	0.35
SENESCENCE	therapeutic_target	process	0.35

Incoming (206)

Source	Relation	Type	Str
ENDOTHELIAL CELLS	interacts_with	cell_type	0.95
PERICYTE	causes	cell_type	0.65
PERICYTE	regulates	cell_type	0.65
ASTROCYTE	activates	cell_type	0.65
ASTROCYTES	activates	cell_type	0.65
PERICYTE	activates	cell_type	0.65
ENDOTHELIAL CELLS	activates	cell_type	0.65
OLIGODENDROCYTE	produces	cell_type	0.65
ENDOTHELIAL	contributes_to	cell_type	0.60
PERICYTE	contributes_to	cell_type	0.60
ALZHEIMER	causes	disease	0.60
ALZHEIMER'S	causes	disease	0.60
APOE	causes	gene	0.60
APOE4	causes	gene	0.60
PERICYTE	stabilizes	cell_type	0.60
ALZHEIMER	activates	disease	0.60
ALZHEIMER'S	activates	disease	0.60
ALZHEIMER'S DISEASE	activates	disease	0.60
ASTROCYTE	inhibits	cell_type	0.60
ASTROCYTES	inhibits	cell_type	0.60
ENDOTHELIAL	treats	cell_type	0.60
PDGF	activates	gene	0.60
PERICYTE	treats	cell_type	0.60
CHAT	interacts_with	gene	0.60
PERICYTE	expressed_in	cell_type	0.60
NEURON	impairs	cell_type	0.60
NEURONS	impairs	cell_type	0.60
PDGF	regulates	gene	0.60
ENDOTHELIAL	co_discussed	entity	0.50
PERICYTE	co_discussed	entity	0.50
APOE	co_discussed	entity	0.50
BBB	co_discussed	entity	0.50
OLIGODENDROCYTE	co_discussed	entity	0.50
OLIGODENDROCYTES	co_discussed	entity	0.50
B CELL	co_discussed	entity	0.50
NEURON	co_discussed	entity	0.50
NEURONS	co_discussed	entity	0.50
PARKINSON	co_discussed	entity	0.50
PARKINSON'S	co_discussed	entity	0.50
FIBROBLASTS	interacts_with	cell_type	0.50
NEURON	regulates	cell_type	0.50
ASTROCYTES	interacts_with	cell_type	0.50
ENDOTHELIAL	associated_with	concept	0.50
PERICYTE	associated_with	concept	0.50
FIBROSIS	associated_with	disease	0.50
microglia	associated_with	cell_type	0.50
Astrocytes	associated_with	cell_type	0.50
NEURONS	associated_with	concept	0.50
OLIGODENDROCYTES	associated_with	concept	0.50
Fibroblast	associated_with	cell_type	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

How does pericyte senescence mechanistically promote glioma cell growth and inva

neurodegeneration | 2026-04-14 | 0 hypotheses

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

PERICYTES

Understanding Entity Pages

Wiki Pages (21)

Pericytes

Progressive Supranuclear Palsy (PSP)

Corticobasal Syndrome (CBS)

Novel Therapy Index

nhp-validation-animal-model

neuroinflammation

TREM2 Mechanism Hub

Circadian Rhythm in Neurodegeneration

Autophagy Mechanisms

Oligodendrocytes

Blood-Brain Barrier Dysfunction in Neurodegeneration

APOC4 — Apolipoprotein C-IV

VEGF/Angiogenesis Pathway in Neurodegeneration

Blood-Brain Barrier Biology and Crossing Strategies

blood-brain-barrier

Astrocytes

GBA1→GCase→Lysosome→PD Causal Chain

Microglial Senescence Pathway in Neurodegeneration

neurovascular-coupling

Quinolinic Acid Neurotoxicity in Neurodegeneration