Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about purinergic receptor: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| microglia | expressed_in | cell_type | 0.90 |
| neurons | expressed_in | cell_type | 0.90 |
| purinergic signaling | activates | pathway | 0.80 |
| astrocytes | expressed_in | cell_type | 0.80 |
| pyroptosis | activates | pathway | 0.80 |
| adenosine | binds | neurotransmitter | 0.70 |
| blood-brain barrier | expressed_in | brain_region | 0.70 |
| neural stem cells | expressed_in | cell_type | 0.70 |
| unfolded protein response | activates | pathway | 0.70 |
| macrophages | expressed_in | cell_type | 0.70 |
| serotonin | binds | neurotransmitter | 0.60 |
| interneurons | expressed_in | cell_type | 0.60 |
| satellite glial cells | expressed_in | cell_type | 0.60 |
| cerebral cortex | expressed_in | brain_region | 0.60 |
| NF-kB signaling | activates | pathway | 0.60 |
| GABAergic neurons | expressed_in | cell_type | 0.60 |
| hippocampus | expressed_in | brain_region | 0.60 |
| synaptic plasticity | activates | pathway | 0.60 |
| cortex | expressed_in | brain_region | 0.60 |
| oligodendrocytes | expressed_in | cell_type | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| neuroinflammation | involves | disease | 0.90 |
| neurodegeneration | involves | disease | 0.90 |
| ATP | implicated_in | gene | 0.90 |
| Alzheimer's disease | involves | disease | 0.90 |
| ATP | activates | gene | 0.90 |
| ATP | releases | gene | 0.90 |
| NLRP3 | inhibits | gene | 0.80 |
| ATP | expressed_in | gene | 0.80 |
| ATP | regulates | gene | 0.80 |
| depression | involves | disease | 0.70 |
| NLRP3 | activates | gene | 0.70 |
| epilepsy | involves | disease | 0.70 |
| NLRP3 | regulates | gene | 0.70 |
| multiple sclerosis | involves | disease | 0.70 |
| ATP | associated_with | gene | 0.70 |
| ATP | inhibits | gene | 0.70 |
| P2RY12 | regulates | gene | 0.60 |
| aspirin | activates | compound | 0.60 |
| aspirin | inhibits | compound | 0.60 |
| NLRP3 | causes | gene | 0.60 |
| NLRP3 | implicated_in | gene | 0.60 |
| HDAC3 | activates | gene | 0.60 |
| HDAC3 | inhibits | gene | 0.60 |
| NLRP3 | suppresses | gene | 0.60 |
| APP | inhibits | gene | 0.60 |
| APP | regulates | gene | 0.60 |
| APP | treats | gene | 0.60 |
| SOD1 | activates | gene | 0.60 |
| SOD1 | regulates | gene | 0.60 |
| GSDMD | regulates | gene | 0.60 |
| GSDMD | interacts_with | gene | 0.60 |
| NLRP3 | interacts_with | gene | 0.60 |
| GSDMD | expressed_in | gene | 0.60 |
| NLRP3 | expressed_in | gene | 0.60 |
| GSDMD | activates | gene | 0.60 |
| GSDMD | promotes | gene | 0.60 |
| NLRP3 | promotes | gene | 0.60 |
| NLRP3 | associated_with | gene | 0.60 |
| GPR109A | associated_with | gene | 0.60 |
| CMKLR1 | associated_with | gene | 0.60 |
| diabetes | involves | disease | 0.60 |
| ATP | causes | gene | 0.60 |
| ATP | interacts_with | gene | 0.60 |
| ATP | transported_by | gene | 0.60 |
| ATP | suppresses | gene | 0.60 |
| RNA | activates | gene | 0.60 |
| RNA | inhibits | gene | 0.60 |
| RNA | associated_with | gene | 0.60 |
| RNA | regulates | gene | 0.60 |
| RNA | implicated_in | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||