Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about DNAJC10: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
DNAJC10 is a protein involved in neurodegeneration research. Key relationships include: expressed in, implicated in. Associated with Cancer, Lymphoma, Ms. Connected to 28 entities in the SciDEX knowledge graph.
| Gene Symbol | DNAJC10 |
| Full Name | DnaJ Heat Shock Protein Family (Hsp40) Member C10 |
| Aliases | ERdj5 |
| Protein Type | Chaperone |
| Function | DNAJC10/ERdj5 possesses multiple domains and functions |
| Primary Expression | cortex, hippocampus, and various brain regions - Cellular Localization: ER lumen, with some |
| Subcellular Localization | the endoplasmic reticulum (ER) where it plays critical roles in protein folding, quality control, and ER-associated degr |
| Molecular Weight | 90.6 kDa |
| Amino Acids | 70 aa |
| GeneCards | DNAJC10 |
| Human Protein Atlas | DNAJC10 |
| J domain | N-terminal |
| Client binding | Central |
| Thioredoxin 1 | C-terminal |
| Thioredoxin 2 | C-terminal |
| Associated Diseases | neurodegeneration |
| KG Connections | 40 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
DNAJC10["<b>DNAJC10</b>"]
Lymphoma{"Lymphoma"}
DNAJC10 -->|"expressed in"| Lymphoma
Ms{"Ms"}
DNAJC10 -->|"expressed in"| Ms
Cancer{"Cancer"}
DNAJC10 -->|"expressed in"| Cancer
Tumor{"Tumor"}
DNAJC10 -->|"expressed in"| Tumor
Apoptosis(["Apoptosis"])
DNAJC10 -->|"expressed in"| Apoptosis
Unfolded_Protein_Response(["Unfolded Protein Response"])
DNAJC10 -->|"expressed in"| Unfolded_Protein_Response
Nf__b(["Nf-Kappab"])
DNAJC10 -->|"expressed in"| Nf__b
Phagocytosis(["Phagocytosis"])
DNAJC10 -->|"expressed in"| Phagocytosis
neurodegeneration["neurodegeneration"]
DNAJC10 -->|"implicated in"| neurodegeneration
UBIQUITIN["UBIQUITIN"]
UBIQUITIN -->|"expressed in"| DNAJC10
CANCER["CANCER"]
CANCER -->|"expressed in"| DNAJC10
BAG3["BAG3"]
BAG3 -->|"expressed in"| DNAJC10
APOPTOSIS["APOPTOSIS"]
APOPTOSIS -->|"expressed in"| DNAJC10
UBC["UBC"]
UBC -->|"expressed in"| DNAJC10
HSPD1["HSPD1"]
HSPD1 -->|"expressed in"| DNAJC10
NF__B["NF-KappaB"]
NF__B -->|"expressed in"| DNAJC10
DNAJC7["DNAJC7"]
DNAJC7 -->|"expressed in"| DNAJC10
HSPA6["HSPA6"]
HSPA6 -->|"expressed in"| DNAJC10
DNAJB1["DNAJB1"]
DNAJB1 -->|"expressed in"| DNAJC10
IKBKB["IKBKB"]
IKBKB -->|"expressed in"| DNAJC10
HSPA1B["HSPA1B"]
HSPA1B -->|"expressed in"| DNAJC10
style DNAJC10 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Lymphoma | expressed_in | disease | 0.65 |
| Ms | expressed_in | disease | 0.65 |
| Cancer | expressed_in | disease | 0.65 |
| Tumor | expressed_in | disease | 0.65 |
| UBIQUITIN | expressed_in | gene | 0.60 |
| HSPD1 | expressed_in | gene | 0.60 |
| HSPH1 | expressed_in | gene | 0.60 |
| HSP90AB1 | expressed_in | gene | 0.60 |
| IKBKB | expressed_in | gene | 0.60 |
| HSPE1 | expressed_in | gene | 0.60 |
| HSPA1A | expressed_in | gene | 0.60 |
| HSP60 | expressed_in | gene | 0.60 |
| DNAJB1 | expressed_in | gene | 0.60 |
| Apoptosis | expressed_in | pathway | 0.60 |
| Unfolded Protein Response | expressed_in | pathway | 0.60 |
| Nf-Κb | expressed_in | pathway | 0.60 |
| Phagocytosis | expressed_in | pathway | 0.60 |
| NF-ΚB | expressed_in | gene | 0.60 |
| AND | expressed_in | gene | 0.60 |
| CANCER | expressed_in | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| UBIQUITIN | expressed_in | gene | 0.60 |
| BAG3 | expressed_in | gene | 0.60 |
| UBC | expressed_in | gene | 0.60 |
| HSPD1 | expressed_in | gene | 0.60 |
| DNAJC7 | expressed_in | gene | 0.60 |
| HSPA6 | expressed_in | gene | 0.60 |
| DNAJB1 | expressed_in | gene | 0.60 |
| IKBKB | expressed_in | gene | 0.60 |
| HSPA1B | expressed_in | gene | 0.60 |
| HSPE1 | expressed_in | gene | 0.60 |
| HSP90AB1 | expressed_in | gene | 0.60 |
| HSP70 | expressed_in | gene | 0.60 |
| HSPH1 | expressed_in | gene | 0.60 |
| HSPA1L | expressed_in | gene | 0.60 |
| HSPA1A | expressed_in | gene | 0.60 |
| CANCER | expressed_in | gene | 0.60 |
| APOPTOSIS | expressed_in | gene | 0.60 |
| NF-ΚB | expressed_in | gene | 0.60 |
| PHAGOCYTOSIS | expressed_in | gene | 0.60 |
| GENES | expressed_in | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||