protein

DNAJC10

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DNAJC10: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

40Connections
0Hypotheses
0Analyses
20Outgoing
20Incoming

Summary

DNAJC10 is a protein involved in neurodegeneration research. Key relationships include: expressed in, implicated in. Associated with Cancer, Lymphoma, Ms. Connected to 28 entities in the SciDEX knowledge graph.

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🔬 Protein Info
Gene SymbolDNAJC10
Full NameDnaJ Heat Shock Protein Family (Hsp40) Member C10
AliasesERdj5
Protein TypeChaperone
FunctionDNAJC10/ERdj5 possesses multiple domains and functions
Primary Expressioncortex, hippocampus, and various brain regions - Cellular Localization: ER lumen, with some
Subcellular Localizationthe endoplasmic reticulum (ER) where it plays critical roles in protein folding, quality control, and ER-associated degr
Molecular Weight90.6 kDa
Amino Acids70 aa
GeneCardsDNAJC10
Human Protein AtlasDNAJC10
J domainN-terminal
Client bindingCentral
Thioredoxin 1C-terminal
Thioredoxin 2C-terminal
Associated Diseasesneurodegeneration
KG Connections40 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Wiki Pages (10)

Knowledge base pages for this entity

Canonical Page

DNAJC10 Gene

gene · 699 words

dnajc4

gene · 2075 words

DNAJB9 Gene

gene · 2073 words

HSPA6

gene · 791 words

HSPH1 Gene

gene · 737 words

DNAJC10 Protein (ERdj5)

protein · 718 words

Pathway Diagram

graph TD
    DNAJC10["<b>DNAJC10</b>"]
    Lymphoma{"Lymphoma"}
    DNAJC10 -->|"expressed in"| Lymphoma
    Ms{"Ms"}
    DNAJC10 -->|"expressed in"| Ms
    Cancer{"Cancer"}
    DNAJC10 -->|"expressed in"| Cancer
    Tumor{"Tumor"}
    DNAJC10 -->|"expressed in"| Tumor
    Apoptosis(["Apoptosis"])
    DNAJC10 -->|"expressed in"| Apoptosis
    Unfolded_Protein_Response(["Unfolded Protein Response"])
    DNAJC10 -->|"expressed in"| Unfolded_Protein_Response
    Nf__b(["Nf-Kappab"])
    DNAJC10 -->|"expressed in"| Nf__b
    Phagocytosis(["Phagocytosis"])
    DNAJC10 -->|"expressed in"| Phagocytosis
    neurodegeneration["neurodegeneration"]
    DNAJC10 -->|"implicated in"| neurodegeneration
    UBIQUITIN["UBIQUITIN"]
    UBIQUITIN -->|"expressed in"| DNAJC10
    CANCER["CANCER"]
    CANCER -->|"expressed in"| DNAJC10
    BAG3["BAG3"]
    BAG3 -->|"expressed in"| DNAJC10
    APOPTOSIS["APOPTOSIS"]
    APOPTOSIS -->|"expressed in"| DNAJC10
    UBC["UBC"]
    UBC -->|"expressed in"| DNAJC10
    HSPD1["HSPD1"]
    HSPD1 -->|"expressed in"| DNAJC10
    NF__B["NF-KappaB"]
    NF__B -->|"expressed in"| DNAJC10
    DNAJC7["DNAJC7"]
    DNAJC7 -->|"expressed in"| DNAJC10
    HSPA6["HSPA6"]
    HSPA6 -->|"expressed in"| DNAJC10
    DNAJB1["DNAJB1"]
    DNAJB1 -->|"expressed in"| DNAJC10
    IKBKB["IKBKB"]
    IKBKB -->|"expressed in"| DNAJC10
    HSPA1B["HSPA1B"]
    HSPA1B -->|"expressed in"| DNAJC10
    style DNAJC10 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (20)

TargetRelationTypeStr
Lymphomaexpressed_indisease0.65
Msexpressed_indisease0.65
Cancerexpressed_indisease0.65
Tumorexpressed_indisease0.65
UBIQUITINexpressed_ingene0.60

Incoming (20)

SourceRelationTypeStr
UBIQUITINexpressed_ingene0.60
BAG3expressed_ingene0.60
UBCexpressed_ingene0.60
HSPD1expressed_ingene0.60
DNAJC7expressed_ingene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found