gene

HSPA1L

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HSPA1L: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

48Connections
0Hypotheses
0Analyses
28Outgoing
20Incoming

Summary

HSPA1L is a gene implicated in neurodegeneration research. Key relationships include: expressed in, regulates, activates. Associated with Cancer, Lymphoma, Ms. Connected to 33 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolHSPA1L
Chromosome1p36.33.
Protein TypeChaperone
Functionis an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight70.2 kDa
Amino Acids641 aa
PathwaysMitophagy
Ensembl IDENSG00000213401
GeneCardsHSPA1L
Human Protein AtlasHSPA1L
Associated DiseasesAls, Cancer
InteractionsPER
KG Connections48 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Wiki Pages (8)

Knowledge base pages for this entity

Canonical Page

HSPA1L Gene

gene · 672 words

Heat Shock Protein Response Pathway in Neurodegeneration

mechanism · 3159 words

Chaperone-Mediated Proteostasis Disease Comparison

mechanism · 2782 words

HSPA1L Protein

protein · 797 words

HSPA6

gene · 791 words

HSPH1 Gene

gene · 737 words

Pathway Diagram

graph TD
    HSPA1L["<b>HSPA1L</b>"]
    Ms{"Ms"}
    HSPA1L -->|"activates"| Ms
    Lymphoma{"Lymphoma"}
    HSPA1L -->|"expressed in"| Lymphoma
    HSPA1L -->|"expressed in"| Ms
    Cancer{"Cancer"}
    HSPA1L -->|"expressed in"| Cancer
    Tumor{"Tumor"}
    HSPA1L -->|"expressed in"| Tumor
    PARKIN["PARKIN"]
    HSPA1L -->|"regulates"| PARKIN
    Mitophagy(["Mitophagy"])
    HSPA1L -->|"regulates"| Mitophagy
    HSPA1A["HSPA1A"]
    HSPA1L -->|"expressed in"| HSPA1A
    DNAJC10["DNAJC10"]
    HSPA1L -->|"expressed in"| DNAJC10
    Apoptosis(["Apoptosis"])
    HSPA1L -->|"expressed in"| Apoptosis
    Unfolded_Protein_Response(["Unfolded Protein Response"])
    HSPA1L -->|"expressed in"| Unfolded_Protein_Response
    Nf__b(["Nf-Kappab"])
    HSPA1L -->|"expressed in"| Nf__b
    PER["PER"]
    PER -->|"activates"| HSPA1L
    MITOPHAGY["MITOPHAGY"]
    MITOPHAGY -->|"regulates"| HSPA1L
    UBIQUITIN["UBIQUITIN"]
    UBIQUITIN -->|"expressed in"| HSPA1L
    CANCER["CANCER"]
    CANCER -->|"expressed in"| HSPA1L
    BAG3["BAG3"]
    BAG3 -->|"expressed in"| HSPA1L
    APOPTOSIS["APOPTOSIS"]
    APOPTOSIS -->|"expressed in"| HSPA1L
    UBC["UBC"]
    UBC -->|"expressed in"| HSPA1L
    HSPD1["HSPD1"]
    HSPD1 -->|"expressed in"| HSPA1L
    NF__B["NF-KappaB"]
    NF__B -->|"expressed in"| HSPA1L
    DNAJC7["DNAJC7"]
    DNAJC7 -->|"expressed in"| HSPA1L
    HSPA6["HSPA6"]
    HSPA6 -->|"expressed in"| HSPA1L
    DNAJB1["DNAJB1"]
    DNAJB1 -->|"expressed in"| HSPA1L
    style HSPA1L fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (28)

TargetRelationTypeStr
Msactivatesdisease0.65
Lymphomaexpressed_indisease0.65
Msexpressed_indisease0.65
Cancerexpressed_indisease0.65
Tumorexpressed_indisease0.65

Incoming (20)

SourceRelationTypeStr
UBIQUITINexpressed_ingene0.60
BAG3expressed_ingene0.60
UBCexpressed_ingene0.60
HSPD1expressed_ingene0.60
DNAJC7expressed_ingene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found