Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about HSPA1L: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
HSPA1L is a gene implicated in neurodegeneration research. Key relationships include: expressed in, regulates, activates. Associated with Cancer, Lymphoma, Ms. Connected to 33 entities in the SciDEX knowledge graph.
| Gene Symbol | HSPA1L |
| Chromosome | 1p36.33. |
| Protein Type | Chaperone |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Molecular Weight | 70.2 kDa |
| Amino Acids | 641 aa |
| Pathways | Mitophagy |
| Ensembl ID | ENSG00000213401 |
| GeneCards | HSPA1L |
| Human Protein Atlas | HSPA1L |
| Associated Diseases | Als, Cancer |
| Interactions | PER |
| KG Connections | 48 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
HSPA1L["<b>HSPA1L</b>"]
Ms{"Ms"}
HSPA1L -->|"activates"| Ms
Lymphoma{"Lymphoma"}
HSPA1L -->|"expressed in"| Lymphoma
HSPA1L -->|"expressed in"| Ms
Cancer{"Cancer"}
HSPA1L -->|"expressed in"| Cancer
Tumor{"Tumor"}
HSPA1L -->|"expressed in"| Tumor
PARKIN["PARKIN"]
HSPA1L -->|"regulates"| PARKIN
Mitophagy(["Mitophagy"])
HSPA1L -->|"regulates"| Mitophagy
HSPA1A["HSPA1A"]
HSPA1L -->|"expressed in"| HSPA1A
DNAJC10["DNAJC10"]
HSPA1L -->|"expressed in"| DNAJC10
Apoptosis(["Apoptosis"])
HSPA1L -->|"expressed in"| Apoptosis
Unfolded_Protein_Response(["Unfolded Protein Response"])
HSPA1L -->|"expressed in"| Unfolded_Protein_Response
Nf__b(["Nf-Kappab"])
HSPA1L -->|"expressed in"| Nf__b
PER["PER"]
PER -->|"activates"| HSPA1L
MITOPHAGY["MITOPHAGY"]
MITOPHAGY -->|"regulates"| HSPA1L
UBIQUITIN["UBIQUITIN"]
UBIQUITIN -->|"expressed in"| HSPA1L
CANCER["CANCER"]
CANCER -->|"expressed in"| HSPA1L
BAG3["BAG3"]
BAG3 -->|"expressed in"| HSPA1L
APOPTOSIS["APOPTOSIS"]
APOPTOSIS -->|"expressed in"| HSPA1L
UBC["UBC"]
UBC -->|"expressed in"| HSPA1L
HSPD1["HSPD1"]
HSPD1 -->|"expressed in"| HSPA1L
NF__B["NF-KappaB"]
NF__B -->|"expressed in"| HSPA1L
DNAJC7["DNAJC7"]
DNAJC7 -->|"expressed in"| HSPA1L
HSPA6["HSPA6"]
HSPA6 -->|"expressed in"| HSPA1L
DNAJB1["DNAJB1"]
DNAJB1 -->|"expressed in"| HSPA1L
style HSPA1L fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Ms | activates | disease | 0.65 |
| Lymphoma | expressed_in | disease | 0.65 |
| Ms | expressed_in | disease | 0.65 |
| Cancer | expressed_in | disease | 0.65 |
| Tumor | expressed_in | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Cancer | associated_with | disease | 0.65 |
| PARKIN | regulates | gene | 0.60 |
| HSPA1A | expressed_in | gene | 0.60 |
| DNAJC10 | expressed_in | gene | 0.60 |
| UBIQUITIN | expressed_in | gene | 0.60 |
| HSPD1 | expressed_in | gene | 0.60 |
| HSPH1 | expressed_in | gene | 0.60 |
| HSP90AB1 | expressed_in | gene | 0.60 |
| IKBKB | expressed_in | gene | 0.60 |
| HSPE1 | expressed_in | gene | 0.60 |
| HSP60 | expressed_in | gene | 0.60 |
| DNAJB1 | expressed_in | gene | 0.60 |
| Mitophagy | regulates | pathway | 0.60 |
| Apoptosis | expressed_in | pathway | 0.60 |
| Unfolded Protein Response | expressed_in | pathway | 0.60 |
| Nf-Κb | expressed_in | pathway | 0.60 |
| Phagocytosis | expressed_in | pathway | 0.60 |
| NF-ΚB | expressed_in | gene | 0.60 |
| AND | expressed_in | gene | 0.60 |
| CANCER | expressed_in | gene | 0.60 |
| PARKINSON | biomarker_for | gene | 0.60 |
| Immune Response | expressed_in | pathway | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| UBIQUITIN | expressed_in | gene | 0.60 |
| BAG3 | expressed_in | gene | 0.60 |
| UBC | expressed_in | gene | 0.60 |
| HSPD1 | expressed_in | gene | 0.60 |
| DNAJC7 | expressed_in | gene | 0.60 |
| HSPA6 | expressed_in | gene | 0.60 |
| DNAJB1 | expressed_in | gene | 0.60 |
| IKBKB | expressed_in | gene | 0.60 |
| HSPA1B | expressed_in | gene | 0.60 |
| HSPE1 | expressed_in | gene | 0.60 |
| HSP90AB1 | expressed_in | gene | 0.60 |
| HSP70 | expressed_in | gene | 0.60 |
| HSPH1 | expressed_in | gene | 0.60 |
| PER | activates | gene | 0.60 |
| MITOPHAGY | regulates | gene | 0.60 |
| CANCER | expressed_in | gene | 0.60 |
| APOPTOSIS | expressed_in | gene | 0.60 |
| NF-ΚB | expressed_in | gene | 0.60 |
| PHAGOCYTOSIS | expressed_in | gene | 0.60 |
| GENES | expressed_in | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||