Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about HSPA6: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
HSPA6 is a gene implicated in neurodegeneration research. Key relationships include: expressed in, implicated in. Associated with Cancer, Lymphoma, Ms. Connected to 28 entities in the SciDEX knowledge graph.
| Gene Symbol | HSPA6 |
| Protein Type | Chaperone |
| Function | HSPA6 (Heat Shock Protein Family A (Hsp70) Member 6) is a member of the Hsp70 family of molecular chaperones. |
| Primary Expression | various cancers: |
| Pathways | Apoptosis, Unfolded Protein Response, Nf-Κb, Phagocytosis |
| Ensembl ID | ENSG00000173110 |
| GeneCards | HSPA6 |
| Human Protein Atlas | HSPA6 |
| Associated Diseases | neurodegeneration |
| KG Connections | 36 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
HSPA6["<b>HSPA6</b>"]
Lymphoma{"Lymphoma"}
HSPA6 -->|"expressed in"| Lymphoma
Ms{"Ms"}
HSPA6 -->|"expressed in"| Ms
Cancer{"Cancer"}
HSPA6 -->|"expressed in"| Cancer
Tumor{"Tumor"}
HSPA6 -->|"expressed in"| Tumor
DNAJB1["DNAJB1"]
HSPA6 -->|"expressed in"| DNAJB1
IKBKB["IKBKB"]
HSPA6 -->|"expressed in"| IKBKB
HSPA1B["HSPA1B"]
HSPA6 -->|"expressed in"| HSPA1B
HSPE1["HSPE1"]
HSPA6 -->|"expressed in"| HSPE1
HSP90AB1["HSP90AB1"]
HSPA6 -->|"expressed in"| HSP90AB1
HSP70["HSP70"]
HSPA6 -->|"expressed in"| HSP70
PHAGOCYTOSIS["PHAGOCYTOSIS"]
HSPA6 -->|"expressed in"| PHAGOCYTOSIS
HSPH1["HSPH1"]
HSPA6 -->|"expressed in"| HSPH1
UBIQUITIN["UBIQUITIN"]
UBIQUITIN -->|"expressed in"| HSPA6
CANCER["CANCER"]
CANCER -->|"expressed in"| HSPA6
BAG3["BAG3"]
BAG3 -->|"expressed in"| HSPA6
APOPTOSIS["APOPTOSIS"]
APOPTOSIS -->|"expressed in"| HSPA6
UBC["UBC"]
UBC -->|"expressed in"| HSPA6
HSPD1["HSPD1"]
HSPD1 -->|"expressed in"| HSPA6
NF__B["NF-KappaB"]
NF__B -->|"expressed in"| HSPA6
DNAJC7["DNAJC7"]
DNAJC7 -->|"expressed in"| HSPA6
style HSPA6 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Lymphoma | expressed_in | disease | 0.65 |
| Ms | expressed_in | disease | 0.65 |
| Cancer | expressed_in | disease | 0.65 |
| Tumor | expressed_in | disease | 0.65 |
| DNAJB1 | expressed_in | gene | 0.60 |
| IKBKB | expressed_in | gene | 0.60 |
| HSPA1B | expressed_in | gene | 0.60 |
| HSPE1 | expressed_in | gene | 0.60 |
| HSP90AB1 | expressed_in | gene | 0.60 |
| HSP70 | expressed_in | gene | 0.60 |
| HSPH1 | expressed_in | gene | 0.60 |
| HSPA1L | expressed_in | gene | 0.60 |
| HSPA1A | expressed_in | gene | 0.60 |
| DNAJC10 | expressed_in | gene | 0.60 |
| UBC | expressed_in | gene | 0.60 |
| UBIQUITIN | expressed_in | gene | 0.60 |
| HSPD1 | expressed_in | gene | 0.60 |
| HSP60 | expressed_in | gene | 0.60 |
| PHAGOCYTOSIS | expressed_in | gene | 0.60 |
| Apoptosis | expressed_in | pathway | 0.60 |
| Unfolded Protein Response | expressed_in | pathway | 0.60 |
| Nf-Κb | expressed_in | pathway | 0.60 |
| Phagocytosis | expressed_in | pathway | 0.60 |
| GENES | expressed_in | gene | 0.60 |
| NF-ΚB | expressed_in | gene | 0.60 |
| AND | expressed_in | gene | 0.60 |
| CANCER | expressed_in | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||