Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about DYNLL1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | DYNLL1 |
| Full Name | Dynein Cytoplasmic 1 Light Chain 1 |
| Chromosome | 12q12 |
| Function | DYNLL1 is a component of the dynein motor complex, essential for retrograde axonal transport. |
| UniProt ID | [P63167](https://www.uniprot.org/uniprotkb/P63167/entry) |
| GeneCards | DYNLL1 |
| Human Protein Atlas | DYNLL1 |
| Associated Diseases | Alzheimer's disease, Charcot-Marie-Tooth disease |
| Known Drugs/Compounds | rapamycin |
| Interactions | EIF4EBP1, GAPDH, HOMER1, JNK1, LAMP1, LC3 |
| KG Connections | 33 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
flowchart TD
N0["DYNLL1"]
N1["EIF4EBP1"]
N0 -->|"activates"| N1
N2["GAPDH"]
N0 -->|"activates"| N2
N3["GFP"]
N0 -->|"activates"| N3
N4["GLUT4"]
N0 -->|"activates"| N4
N5["HOMER1"]
N0 -->|"activates"| N5
N6["JNK1"]
N0 -->|"activates"| N6
N7["LAMP1"]
N0 -->|"activates"| N7
N8["LC3"]
N0 -->|"activates"| N8
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class N0 gene
class N1 gene
class N2 gene
class N3 gene
class N4 gene
class N5 gene
class N6 gene
class N7 gene
class N8 gene| Target | Relation | Type | Str |
|---|---|---|---|
| EIF4EBP1 | activates | gene | 0.60 |
| GAPDH | activates | gene | 0.60 |
| HOMER1 | activates | gene | 0.60 |
| JNK1 | activates | gene | 0.60 |
| LAMP1 | activates | gene | 0.60 |
| LC3 | activates | gene | 0.60 |
| MAP1LC3B | activates | gene | 0.60 |
| MAP2 | activates | gene | 0.60 |
| MAPK14 | activates | gene | 0.60 |
| MAPK8 | activates | gene | 0.60 |
| MCOLN1 | activates | gene | 0.60 |
| RILP | activates | gene | 0.60 |
| SLC2A4 | activates | gene | 0.60 |
| TSC2 | activates | gene | 0.60 |
| ULK1 | activates | gene | 0.60 |
| GFP | activates | gene | 0.60 |
| GLUT4 | activates | gene | 0.60 |
| LC3B | activates | gene | 0.60 |
| TRPML1 | activates | gene | 0.60 |
| autophagy pathway | participates_in | pathway | 0.60 |
| oxidative stress response | participates_in | pathway | 0.60 |
| ubiquitin-proteasome | participates_in | pathway | 0.60 |
| ROS | activates | gene | 0.60 |
| MAPK signaling | participates_in | pathway | 0.60 |
| neurons | expressed_in | cell_type | 0.55 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||