gene

TSC2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TSC2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

347Connections

0Hypotheses

2Analyses

50Outgoing

50Incoming

Summary

TSC2 is a gene implicated in neurodegeneration research. Key relationships include: activates, regulates, interacts with. Associated with Als, Atherosclerosis, Autism. Connected to 180 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	TSC2
Full Name	Tuberous Sclerosis Complex 2
Function	The TSC1-TSC2 heterodimer localizes primarily to the cytoplasm and intracellular membranes, where it senses cellular energy status and growth factor signals.
Primary Expression	neurons and regulates synaptic function
Subcellular Localization	synapses and regulates dendritic spine morphology and synaptic plasticity
Molecular Weight	200 kDa
Amino Acids	807 aa
Pathways	mTOR, mtor, AMPK, PI3K
Ensembl ID	ENSG00000103197
GeneCards	TSC2
Human Protein Atlas	TSC2
Inhibition of Rheb	The GAP activity of TSC2 converts active GTP-bound Rheb to inactive GDP-bound Rheb, thereby inhibiting mTORC1 activation<sup>[2]</sup>
Energy sensing	TSC2 senses cellular energy (AMP/ATP ratio) through AMPK activation, inhibiting mTORC1 during energy deprivation
Growth factor regulation	PI3K/Akt signaling phosphorylates and inhibits TSC2, allowing mTORC1 activation in response to growth factors
Cell cycle control	TSC2 loss leads to uncontrolled cell proliferation
Associated Diseases	ALS, Diabetes, Ms, Parkinson, epilepsy, neurodegeneration
Known Drugs/Compounds	rapamycin
Interactions	EGF, TFEB, MTOR, AKT, LC3, TSC1
KG Connections	347 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    TSC2["TSC2"]
    TSC2 -->|"inhibits"| mTORC1["mTORC1"]
    TSC2 -->|"regulates"| TFEB["TFEB"]
    TSC2 -->|"inhibits"| MTORC1["MTORC1"]
    TSC2 -->|"binds"| Akt["Akt"]
    TSC2 -->|"inhibits"| mTOR["mTOR"]
    TSC2 -->|"activates"| Ms["Ms"]
    TSC2 -->|"regulates"| Leukemia["Leukemia"]
    TSC2 -->|"regulates"| Als["Als"]
    TSC2 -->|"regulates"| Autism["Autism"]
    TSC2 -->|"activates"| Tumor["Tumor"]
    AKT["AKT"] -->|"phosphorylates"| TSC2
    TSC1["TSC1"] -->|"interacts"| TSC2
    Akt -->|"phosphorylates"| TSC2
    alpha_synuclein["alpha-synuclein"] -->|"interacts"| TSC2
    mTOR -->|"regulates"| TSC2
    EGF["EGF"] -->|"activates"| TSC2
    LC3["LC3"] -->|"activates"| TSC2
    MTOR["MTOR"] -->|"activates"| TSC2

Outgoing (191)

Target	Relation	Type	Str
mTOR Signaling	inhibits	pathway	0.95
mTORC1	inhibits	pathway	0.90
Mtor	activates	pathway	0.90
Mtor	interacts_with	pathway	0.90
TFEB	regulates	gene	0.85
Als	interacts_with	disease	0.85
MTORC1	inhibits	protein	0.80
Akt	binds	protein	0.80
MTOR	activates	gene	0.80
TSC1	inhibits	gene	0.80
MTOR	interacts_with	gene	0.80
MTORC1	activates	gene	0.80
Tumor	activates	disease	0.75
Cancer	activates	disease	0.75
Als	inhibits	disease	0.75
Carcinoma	activates	disease	0.75
Autism	interacts_with	disease	0.75
AKT	activates	gene	0.70
MTOR	inhibits	gene	0.70
MTOR	regulates	gene	0.70
TSC1	interacts_with	gene	0.70
Autophagy	activates	pathway	0.70
Mtor	inhibits	pathway	0.70
Mtor	regulates	pathway	0.70
mTOR	inhibits	protein	0.70
AUTOPHAGY	activates	gene	0.70
GENES	inhibits	gene	0.70
autophagy pathway	participates_in	pathway	0.70
oxidative stress response	participates_in	pathway	0.70
senescence	participates_in	pathway	0.70
Ms	activates	disease	0.65
Leukemia	regulates	disease	0.65
Als	regulates	disease	0.65
Autism	regulates	disease	0.65
Ms	therapeutic_target	disease	0.65
Carcinoma	interacts_with	disease	0.65
Neurodegeneration	interacts_with	disease	0.65
Parkinson	interacts_with	disease	0.65
Carcinoma	inhibits	disease	0.65
Glioblastoma	activates	disease	0.65
Als	activates	disease	0.65
Diabetes	associated_with	disease	0.65
Ms	inhibits	disease	0.65
Neurodegeneration	inhibits	disease	0.65
Cancer	regulates	disease	0.65
Atherosclerosis	regulates	disease	0.65
Hepatocellular Carcinoma	activates	disease	0.65
Epilepsy	interacts_with	disease	0.65
Tumor	interacts_with	disease	0.65
Cardiac	interacts_with	disease	0.65

Incoming (156)

Source	Relation	Type	Str
pathologic α-synuclein	binds_to	protein	0.95
AKT	phosphorylates	protein	0.90
AKT	inhibits	protein	0.90
TSC1	interacts_with	protein	0.90
SNCA	binds	protein	0.90
Akt	phosphorylates	protein	0.90
Akt	inhibits	protein	0.90
alpha-synuclein	interacts_with	protein	0.85
RPS6	activates	gene	0.70
AKT1	activates	gene	0.70
SIRT1	activates	gene	0.70
SIRT1	modifies	gene	0.70
SIRT1	regulates	gene	0.70
LYSOSOMAL BIOGENESIS	activates	gene	0.70
mTOR	regulates	pathway	0.70
GLUT4	activates	gene	0.65
EGF	activates	gene	0.60
LC3	activates	gene	0.60
MTOR	activates	gene	0.60
AKT	regulates	gene	0.60
EGF	regulates	gene	0.60
LC3	regulates	gene	0.60
TSC1	inhibits	gene	0.60
MTOR	inhibits	gene	0.60
UBIQUITIN	regulates	gene	0.60
ATF4	regulates	gene	0.60
AKT	activates	gene	0.60
PIK3C3	activates	gene	0.60
YWHAG	activates	gene	0.60
RICTOR	activates	gene	0.60
ENDOG	activates	gene	0.60
BIP	activates	gene	0.60
HDAC6	biomarker_for	gene	0.60
MAPK8	biomarker_for	gene	0.60
TARDBP	associated_with	gene	0.60
PTEN	activates	gene	0.60
RHEB	activates	gene	0.60
RPS6KB1	activates	gene	0.60
PDPK1	activates	gene	0.60
PI3K	inhibits	gene	0.60
FOXO1	activates	gene	0.60
TSC1	causes	gene	0.60
DDB1	regulates	gene	0.60
TFEB	activates	gene	0.60
FGF21	interacts_with	gene	0.60
ERN1	activates	gene	0.60
PERK	activates	gene	0.60
HSPA5	activates	gene	0.60
MTOR	interacts_with	gene	0.60
HEXB	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (2)

Scientific analyses that reference this entity

Sleep disruption as cause and consequence of neurodegeneration

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.557

Autophagy-lysosome pathway convergence across neurodegenerative diseases

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.665

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

TSC2

Understanding Entity Pages

Summary

Wiki Pages (21)

TSC2 — Tuberous Sclerosis Complex 2

Insulin Signaling in Parkinson's Disease

rapamycin-tauopathy

cortisol-tau-pathway

AMPK Signaling Pathway

Cerebellar Purkinje Cells in Autism Spectrum Disorder

RRAGB — Ras-Related GTP Binding B

AKT2 Gene

mTOR Signaling in Neurodegeneration

Sirtuin Signaling Pathway

Autophagy-Lysosomal Pathway

pi3k-akt-signaling

NPRL2 Gene

RRAGA — Ras-Related GTP Binding A

LRRK2 Kinase Pathway in Parkinson's Disease

Autophagy Molecular Regulation in Neurodegeneration

AMPK Signaling in Neurodegeneration

PRKAA2 (AMPKα2) — AMP-Activated Protein Kinase Catalytic Subunit Alpha 2

mTOR Signaling Dysregulation in Progressive Supranuclear Palsy

RICTOR Gene

PI3K/Akt Signaling in Neurodegeneration