gene

HOMER1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HOMER1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

71Connections
0Hypotheses
0Analyses
43Outgoing
28Incoming

Summary

HOMER1 encodes Homer scaffold proteins regulating synaptic plasticity and metabotropic glutamate receptor signaling

View on Wiki →

🧬 Gene Info
Gene SymbolHOMER1
Full NameHomer Scaffold Protein 1
Chromosome5q14.1
Protein FamilyHomer scaffolding proteins
UniProt IDQ86YM7
NCBI Gene ID9456
Ensembl IDENSG00000159307
OMIM604798
GeneCardsHOMER1
Human Protein AtlasHOMER1
Associated DiseasesALS, Hallucination, Ms, Parkinson, levodopa adverse drug reactions
Known Drugs/Compoundslevodopa, rapamycin
InteractionsMTHFR, JNK1, LAMP1, LC3, MAP1LC3B, MAP2
KG Connections71 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: HOMER1 — AlphaFold Q86YM7 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

HOMER1 Gene

gene · 1513 words

Epigenetic Dysregulation in Neurodegeneration

mechanism · 4376 words

Epigenetic Mechanisms in Alzheimer's Disease

mechanism · 3425 words

SETD1B

gene · 3299 words

Synaptic Dysfunction Pathway

mechanism · 3282 words

Integrated Stress Response in Alzheimer's Disease

mechanism · 2816 words

Pathway Diagram

graph TD
    HOMER1["<b>HOMER1</b>"]
    Ms{"Ms"}
    HOMER1 -->|"associated with"| Ms
    Parkinson{"Parkinson"}
    HOMER1 -->|"associated with"| Parkinson
    Als{"Als"}
    HOMER1 -->|"associated with"| Als
    ALS{"ALS"}
    HOMER1 -->|"associated with"| ALS
    COMT["COMT"]
    HOMER1 -->|"associated with"| COMT
    SRC["SRC"]
    HOMER1 -->|"associated with"| SRC
    UBC["UBC"]
    HOMER1 -->|"associated with"| UBC
    SNCA["SNCA"]
    HOMER1 -->|"associated with"| SNCA
    DRD2["DRD2"]
    HOMER1 -->|"associated with"| DRD2
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    HOMER1 -->|"associated with"| PARKINSON_S_DISEASE
    SLC6A3["SLC6A3"]
    HOMER1 -->|"associated with"| SLC6A3
    CAMK2A["CAMK2A"]
    HOMER1 -->|"associated with"| CAMK2A
    DRD2 -->|"associated with"| HOMER1
    FYN["FYN"]
    FYN -->|"associated with"| HOMER1
    SRC -->|"associated with"| HOMER1
    CAMK2A -->|"associated with"| HOMER1
    SNCA -->|"associated with"| HOMER1
    SLC6A3 -->|"associated with"| HOMER1
    UBC -->|"associated with"| HOMER1
    COMT -->|"associated with"| HOMER1
    GENES["GENES"]
    GENES -->|"associated with"| HOMER1
    PARKINSON_S_DISEASE -->|"associated with"| HOMER1
    PARKINSON["PARKINSON"]
    PARKINSON -->|"associated with"| HOMER1
    AND["AND"]
    AND -->|"associated with"| HOMER1
    style HOMER1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (43)

TargetRelationTypeStr
Hallucinationassociated_withphenotype0.85
hallucinationbiomarker_forphenotype0.80
levodopa adverse drug reactionsassociated_withphenotype0.75
Msassociated_withdisease0.65
Parkinsonassociated_withdisease0.65

Incoming (28)

SourceRelationTypeStr
DRD2associated_withgene0.60
FYNassociated_withgene0.60
SRCassociated_withgene0.60
CAMK2Aassociated_withgene0.60
SNCAassociated_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found