Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about HOMER1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
HOMER1 encodes Homer scaffold proteins regulating synaptic plasticity and metabotropic glutamate receptor signaling
| Gene Symbol | HOMER1 |
| Full Name | Homer Scaffold Protein 1 |
| Chromosome | 5q14.1 |
| Protein Family | Homer scaffolding proteins |
| UniProt ID | Q86YM7 |
| NCBI Gene ID | 9456 |
| Ensembl ID | ENSG00000159307 |
| OMIM | 604798 |
| GeneCards | HOMER1 |
| Human Protein Atlas | HOMER1 |
| Associated Diseases | ALS, Hallucination, Ms, Parkinson, levodopa adverse drug reactions |
| Known Drugs/Compounds | levodopa, rapamycin |
| Interactions | MTHFR, JNK1, LAMP1, LC3, MAP1LC3B, MAP2 |
| KG Connections | 71 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
HOMER1["<b>HOMER1</b>"]
Ms{"Ms"}
HOMER1 -->|"associated with"| Ms
Parkinson{"Parkinson"}
HOMER1 -->|"associated with"| Parkinson
Als{"Als"}
HOMER1 -->|"associated with"| Als
ALS{"ALS"}
HOMER1 -->|"associated with"| ALS
COMT["COMT"]
HOMER1 -->|"associated with"| COMT
SRC["SRC"]
HOMER1 -->|"associated with"| SRC
UBC["UBC"]
HOMER1 -->|"associated with"| UBC
SNCA["SNCA"]
HOMER1 -->|"associated with"| SNCA
DRD2["DRD2"]
HOMER1 -->|"associated with"| DRD2
PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
HOMER1 -->|"associated with"| PARKINSON_S_DISEASE
SLC6A3["SLC6A3"]
HOMER1 -->|"associated with"| SLC6A3
CAMK2A["CAMK2A"]
HOMER1 -->|"associated with"| CAMK2A
DRD2 -->|"associated with"| HOMER1
FYN["FYN"]
FYN -->|"associated with"| HOMER1
SRC -->|"associated with"| HOMER1
CAMK2A -->|"associated with"| HOMER1
SNCA -->|"associated with"| HOMER1
SLC6A3 -->|"associated with"| HOMER1
UBC -->|"associated with"| HOMER1
COMT -->|"associated with"| HOMER1
GENES["GENES"]
GENES -->|"associated with"| HOMER1
PARKINSON_S_DISEASE -->|"associated with"| HOMER1
PARKINSON["PARKINSON"]
PARKINSON -->|"associated with"| HOMER1
AND["AND"]
AND -->|"associated with"| HOMER1
style HOMER1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Hallucination | associated_with | phenotype | 0.85 |
| hallucination | biomarker_for | phenotype | 0.80 |
| levodopa adverse drug reactions | associated_with | phenotype | 0.75 |
| Ms | associated_with | disease | 0.65 |
| Parkinson | associated_with | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| ALS | associated_with | disease | 0.65 |
| COMT | associated_with | gene | 0.60 |
| SRC | associated_with | gene | 0.60 |
| UBC | associated_with | gene | 0.60 |
| SNCA | associated_with | gene | 0.60 |
| DRD2 | associated_with | gene | 0.60 |
| SLC6A3 | associated_with | gene | 0.60 |
| CAMK2A | associated_with | gene | 0.60 |
| FYN | associated_with | gene | 0.60 |
| MTHFR | interacts_with | gene | 0.60 |
| JNK1 | activates | gene | 0.60 |
| LAMP1 | activates | gene | 0.60 |
| LC3 | activates | gene | 0.60 |
| MAP1LC3B | activates | gene | 0.60 |
| MAP2 | activates | gene | 0.60 |
| MAPK14 | activates | gene | 0.60 |
| MAPK8 | activates | gene | 0.60 |
| MCOLN1 | activates | gene | 0.60 |
| RILP | activates | gene | 0.60 |
| SLC2A4 | activates | gene | 0.60 |
| TSC2 | activates | gene | 0.60 |
| ULK1 | activates | gene | 0.60 |
| PARKINSON'S DISEASE | associated_with | gene | 0.60 |
| AND | associated_with | gene | 0.60 |
| PARKINSON | associated_with | gene | 0.60 |
| GENES | associated_with | gene | 0.60 |
| App | associated_with | protein | 0.60 |
| LC3B | activates | gene | 0.60 |
| TRPML1 | activates | gene | 0.60 |
| autophagy pathway | participates_in | pathway | 0.60 |
| oxidative stress response | participates_in | pathway | 0.60 |
| ubiquitin-proteasome | participates_in | pathway | 0.60 |
| ROS | activates | gene | 0.60 |
| MAPK signaling | participates_in | pathway | 0.60 |
| neurons | expressed_in | cell_type | 0.55 |
| SLC6A3 | co_expressed_with | gene | 0.50 |
| SNCA | co_expressed_with | gene | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| DRD2 | associated_with | gene | 0.60 |
| FYN | associated_with | gene | 0.60 |
| SRC | associated_with | gene | 0.60 |
| CAMK2A | associated_with | gene | 0.60 |
| SNCA | associated_with | gene | 0.60 |
| SLC6A3 | associated_with | gene | 0.60 |
| UBC | associated_with | gene | 0.60 |
| COMT | associated_with | gene | 0.60 |
| levodopa | targets | drug | 0.60 |
| ATG5 | activates | gene | 0.60 |
| ATM | activates | gene | 0.60 |
| ATR | activates | gene | 0.60 |
| CASP3 | activates | gene | 0.60 |
| CTSB | activates | gene | 0.60 |
| CTSD | activates | gene | 0.60 |
| DYNLL1 | activates | gene | 0.60 |
| EIF4EBP1 | activates | gene | 0.60 |
| GAPDH | activates | gene | 0.60 |
| GENES | associated_with | gene | 0.60 |
| PARKINSON'S DISEASE | associated_with | gene | 0.60 |
| PARKINSON | associated_with | gene | 0.60 |
| AMPK | activates | gene | 0.60 |
| GFP | activates | gene | 0.60 |
| GLUT4 | activates | gene | 0.60 |
| rapamycin | targets | drug | 0.60 |
| DRD2 | interacts_with | gene | 0.50 |
| DRD2 | co_expressed_with | gene | 0.50 |
| FYN | co_expressed_with | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||