SLC2A4

Understanding Entity Pages

This page aggregates everything SciDEX knows about SLC2A4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

Solute Carrier Family 2 Member 4 (GLUT4) gene

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graph TD
    ASPSCR1["ASPSCR1"]
    SLC2A4["SLC2A4<br/>(GLUT4)"]
    GlucoseUptake["Glucose Uptake"]
    InsulinSignaling["Insulin Signaling"]
    PI3K_AKT["PI3K/AKT Pathway"]
    GLUT4_Translocation["GLUT4 Translocation"]
    Neuronal_Metabolism["Neuronal Glucose Metabolism"]
    Energy_Production["ATP Production"]
    Metabolic_Dysfunction["Metabolic Dysfunction"]
    Insulin_Resistance["Insulin Resistance"]
    Oxidative_Stress["Oxidative Stress"]
    Neuroinflammation["Neuroinflammation"]
    Protein_Aggregation["Protein Aggregation"]
    Synaptic_Dysfunction["Synaptic Dysfunction"]
    Neurodegeneration["Neurodegeneration"]

    ASPSCR1 -->|"regulates"| SLC2A4
    InsulinSignaling -->|"activates"| PI3K_AKT
    PI3K_AKT -->|"promotes"| GLUT4_Translocation
    GLUT4_Translocation -->|"enhances"| SLC2A4
    SLC2A4 -->|"mediates"| GlucoseUptake
    GlucoseUptake -->|"supports"| Neuronal_Metabolism
    Neuronal_Metabolism -->|"generates"| Energy_Production
    Insulin_Resistance -->|"impairs"| PI3K_AKT
    Metabolic_Dysfunction -->|"reduces"| GlucoseUptake
    Metabolic_Dysfunction -->|"promotes"| Oxidative_Stress
    Oxidative_Stress -->|"triggers"| Neuroinflammation
    Neuroinflammation -->|"induces"| Protein_Aggregation
    Protein_Aggregation -->|"causes"| Synaptic_Dysfunction
    Synaptic_Dysfunction -->|"leads to"| Neurodegeneration
    Energy_Production -->|"prevents"| Metabolic_Dysfunction

    classDef central fill:#1a3a4a,stroke:#4fc3f7,stroke-width:2px,color:#fff
    classDef protective fill:#1a3a2a,stroke:#81c784,stroke-width:2px,color:#fff
    classDef pathological fill:#3a1a1a,stroke:#ef5350,stroke-width:2px,color:#fff
    classDef regulatory fill:#2a1a3a,stroke:#ce93d8,stroke-width:2px,color:#fff
    classDef disease fill:#3a2a1a,stroke:#ffa726,stroke-width:2px,color:#fff

    class SLC2A4 central
    class GlucoseUptake,Neuronal_Metabolism,Energy_Production protective
    class Metabolic_Dysfunction,Insulin_Resistance,Oxidative_Stress,Neuroinflammation,Protein_Aggregation,Synaptic_Dysfunction pathological
    class ASPSCR1,InsulinSignaling,PI3K_AKT,GLUT4_Translocation regulatory
    class Neurodegeneration disease