gene

CHUK

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CHUK: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

94Connections

0Hypotheses

0Analyses

50Outgoing

39Incoming

Summary

CHUK gene encodes IKK alpha, a critical serine/threonine kinase in NF-κB signaling pathway, with essential roles in neuroinflammation, microglial activation, and neuronal survival in neurodegenerative diseases.

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🧬 Gene Info

Gene Symbol	CHUK
Full Name	IKK Alpha (IκB Kinase Alpha)
Chromosome	10q24.31
Protein Type	Kinase
Function	is a critical serine/threonine protein kinase that plays a central role in the NF-κB signaling pathway.
Molecular Weight	85 kDa
Amino Acids	745 aa
Exons	21
Pathways	NF-κB signaling
UniProt ID	[O15111](https://www.uniprot.org/uniprot/O15111)
Ensembl ID	ENSG00000028137
OMIM	600655
GeneCards	CHUK
Human Protein Atlas	CHUK
Histone H3	At Ser10, linking NF-κB to chromatin remodeling
Associated Diseases	neurodegeneration
Interactions	GAIN, MTOR, IKBKB, PRDX6, MAPK14, BECN1
KG Connections	94 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (7)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    CHUK["CHUK"] -->|"activates"| Cancer["Cancer"]
    CHUK["CHUK"] -->|"therapeutic target"| Diabetes["Diabetes"]
    CHUK["CHUK"] -->|"therapeutic target"| Obesity["Obesity"]
    CHUK["CHUK"] -->|"therapeutic target"| Stroke["Stroke"]
    CHUK["CHUK"] -->|"therapeutic target"| Als["Als"]
    CHUK["CHUK"] -->|"therapeutic target"| Hypertension["Hypertension"]
    IKBKB["IKBKB"] -.->|"inhibits"| CHUK["CHUK"]
    DSDNA["DSDNA"] -->|"therapeutic target"| CHUK["CHUK"]
    GAIN["GAIN"] -.->|"inhibits"| CHUK["CHUK"]
    MTOR["MTOR"] -.->|"inhibits"| CHUK["CHUK"]
    style CHUK fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (55)

Target	Relation	Type	Str
Cancer	activates	disease	0.65
Diabetes	therapeutic_target	disease	0.65
Obesity	therapeutic_target	disease	0.65
Stroke	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Hypertension	therapeutic_target	disease	0.65
Ischemia	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Infection	activates	disease	0.65
GAIN	inhibits	gene	0.60
MTOR	inhibits	gene	0.60
IKBKB	inhibits	gene	0.60
PRDX6	activates	gene	0.60
MAPK14	activates	gene	0.60
BECN1	activates	gene	0.60
TNF	activates	gene	0.60
ECSIT	activates	gene	0.60
MAP3K7	activates	gene	0.60
TLR4	activates	gene	0.60
RELA	activates	gene	0.60
TAK1	activates	gene	0.60
IKBKB	activates	gene	0.60
IL6	activates	gene	0.60
LC3	activates	gene	0.60
PRDX1	activates	gene	0.60
JUN	therapeutic_target	gene	0.60
IL1B	activates	gene	0.60
UBIQUITIN	activates	gene	0.60
RAF1	therapeutic_target	gene	0.60
TNF	therapeutic_target	gene	0.60
PRKACA	therapeutic_target	gene	0.60
Mtor	inhibits	pathway	0.60
Tgf-Β	therapeutic_target	pathway	0.60
Mapk	therapeutic_target	pathway	0.60
NFKB	activates	gene	0.60
Nf-Kb	activates	pathway	0.60
Autophagy	activates	pathway	0.60
Mapk	activates	pathway	0.60
DSDNA	associated_with	gene	0.60
Mapk	associated_with	pathway	0.60
MAP1LC3	activates	gene	0.60
Jak-Stat	therapeutic_target	pathway	0.60
Akt	therapeutic_target	pathway	0.60
Pi3K	therapeutic_target	pathway	0.60
Mapk	phosphorylates	pathway	0.60
Tgf-Β	phosphorylates	pathway	0.60
CANCER	activates	gene	0.60
Invasion	activates	pathway	0.60
AND	activates	gene	0.60
NF-KB	activates	gene	0.60

Incoming (39)

Source	Relation	Type	Str
IKBKB	inhibits	gene	0.60
GAIN	inhibits	gene	0.60
MTOR	inhibits	gene	0.60
P38	activates	gene	0.60
IL1B	activates	gene	0.60
PRDX1	activates	gene	0.60
TRAF6	activates	gene	0.60
TLR4	activates	gene	0.60
UBIQUITIN	activates	gene	0.60
MAPK14	activates	gene	0.60
TNF	activates	gene	0.60
MAP3K7	activates	gene	0.60
LC3	activates	gene	0.60
BECN1	activates	gene	0.60
ECSIT	activates	gene	0.60
PI3K	therapeutic_target	gene	0.60
RELA	therapeutic_target	gene	0.60
PTGS2	therapeutic_target	gene	0.60
PRKACA	therapeutic_target	gene	0.60
AKT1	therapeutic_target	gene	0.60
TNF	therapeutic_target	gene	0.60
RAF1	therapeutic_target	gene	0.60
TAK1	activates	gene	0.60
RELA	activates	gene	0.60
PRDX6	activates	gene	0.60
IL6	activates	gene	0.60
DSDNA	therapeutic_target	gene	0.60
MAP1LC3	activates	gene	0.60
CANCER	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
NF-KB	activates	gene	0.60
JAK	therapeutic_target	gene	0.60
DSDNA	phosphorylates	gene	0.60
HIPPO	phosphorylates	gene	0.60
NFKB	activates	gene	0.60
AND	inhibits	gene	0.60
STROKE	therapeutic_target	gene	0.60
IL-17	therapeutic_target	gene	0.60
mTOR	inhibits	entity	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

CHUK

Understanding Entity Pages

Summary

Wiki Pages (7)

CHUK — IKK Alpha (IκB Kinase Alpha)

ECSIT — Evolutionarily Conserved Signaling Intermediate in Toll Pathways

NF-κB Signaling in Parkinson's Disease

IKKBETA Gene

IKK Alpha Protein