gene

HBA1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HBA1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

71Connections

0Hypotheses

0Analyses

38Outgoing

33Incoming

Summary

HBA1 Gene

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🧬 Gene Info

Gene Symbol	HBA1
Full Name	Hemoglobin Subunit Alpha 1
Aliases	HBA-T1, alpha-globin
Chromosome	16p13.3
Function	encodes the alpha-globin chain of hemoglobin, the oxygen-carrying protein in red blood cells
UniProt ID	P69905
NCBI Gene ID	3039
Ensembl ID	ENSG00000188536
GeneCards	HBA1
Human Protein Atlas	HBA1
Protein Name	Hemoglobin subunit alpha
Associated Diseases	neurodegeneration
Interactions	Hemoglobin, RNA, Interferon, ARG1, CHI3L1, MMP9
KG Connections	71 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: HBA1 — AlphaFold P69905 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    HBA1["<b>HBA1</b>"]
    Nephropathy["Nephropathy"]
    HBA1 -->|"therapeutic target"| Nephropathy
    Diabetes["Diabetes"]
    HBA1 -->|"therapeutic target"| Diabetes
    Hypertension["Hypertension"]
    HBA1 -->|"therapeutic target"| Hypertension
    Als["Als"]
    HBA1 -->|"biomarker for"| Als
    Retinopathy["Retinopathy"]
    HBA1 -->|"therapeutic target"| Retinopathy
    Alzheimer["Alzheimer"]
    HBA1 -->|"therapeutic target"| Alzheimer
    Parkinson["Parkinson"]
    HBA1 -->|"therapeutic target"| Parkinson
    Neuroinflammation["Neuroinflammation"]
    HBA1 -->|"therapeutic target"| Neuroinflammation
    Alzheimer["Alzheimer"]
    HBA1 -->|"biomarker for"| Alzheimer
    Neuroinflammation["Neuroinflammation"]
    HBA1 -->|"biomarker for"| Neuroinflammation
    Parkinson["Parkinson"]
    HBA1 -->|"biomarker for"| Parkinson
    Inflammation["Inflammation"]
    HBA1 -->|"biomarker for"| Inflammation
    Cholesterol["Cholesterol"]
    HBA1 -->|"therapeutic target"| Cholesterol
    ALZHEIMER["ALZHEIMER"]
    HBA1 -->|"therapeutic target"| ALZHEIMER
    TNF["TNF"]
    HBA1 -->|"therapeutic target"| TNF
    RNA["RNA"]
    HBA1 -->|"inhibits"| RNA
    PLCG2["PLCG2"]
    HBA1 -->|"therapeutic target"| PLCG2
    PARKINSON["PARKINSON"]
    HBA1 -->|"therapeutic target"| PARKINSON
    NFE2L2["NFE2L2"]
    HBA1 -->|"therapeutic target"| NFE2L2
    Oxidative_Stress["Oxidative Stress"]
    HBA1 -->|"therapeutic target"| Oxidative_Stress
    Epigenetic["Epigenetic"]
    HBA1 -->|"therapeutic target"| Epigenetic
    Nf__b["Nf-Kappab"]
    HBA1 -->|"therapeutic target"| Nf__b
    Microglia["Microglia"]
    HBA1 -->|"therapeutic target"| Microglia
    Neuron["Neuron"]
    HBA1 -->|"therapeutic target"| Neuron
    NEURODEGENERATIVE_DISORDERS["NEURODEGENERATIVE DISORDERS"]
    HBA1 -->|"biomarker for"| NEURODEGENERATIVE_DISORDERS
    Oxidative_Stress["Oxidative Stress"]
    HBA1 -->|"biomarker for"| Oxidative_Stress
    Epigenetic["Epigenetic"]
    HBA1 -->|"biomarker for"| Epigenetic
    Nf__b["Nf-Kappab"]
    HBA1 -->|"biomarker for"| Nf__b
    NRF2["NRF2"]
    NRF2 -->|"therapeutic target"| HBA1
    NEUROINFLAMMATION["NEUROINFLAMMATION"]
    NEUROINFLAMMATION -->|"biomarker for"| HBA1

Outgoing (38)

Target	Relation	Type	Str
Nephropathy	therapeutic_target	disease	0.65
Diabetes	therapeutic_target	disease	0.65
Hypertension	therapeutic_target	disease	0.65
Als	biomarker_for	disease	0.65
Retinopathy	therapeutic_target	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Neuroinflammation	therapeutic_target	disease	0.65
Alzheimer	biomarker_for	disease	0.65
Neuroinflammation	biomarker_for	disease	0.65
Parkinson	biomarker_for	disease	0.65
Inflammation	biomarker_for	disease	0.65
Multiple Sclerosis	expressed_in	disease	0.65
TNF	therapeutic_target	gene	0.60
PLCG2	therapeutic_target	gene	0.60
NFE2L2	therapeutic_target	gene	0.60
Hemoglobin	inhibits	protein	0.60
Hemoglobin	activates	protein	0.60
Cholesterol	therapeutic_target	pathway	0.60
ALZHEIMER	therapeutic_target	gene	0.60
RNA	inhibits	gene	0.60
PARKINSON	therapeutic_target	gene	0.60
Oxidative Stress	therapeutic_target	pathway	0.60
Epigenetic	therapeutic_target	pathway	0.60
Nf-Κb	therapeutic_target	pathway	0.60
Microglia	therapeutic_target	cell_type	0.60
Neuron	therapeutic_target	cell_type	0.60
NEURODEGENERATIVE DISORDERS	biomarker_for	gene	0.60
Oxidative Stress	biomarker_for	pathway	0.60
Epigenetic	biomarker_for	pathway	0.60
Nf-Κb	biomarker_for	pathway	0.60
Neutrophil	activates	cell_type	0.60
Interferon	activates	protein	0.60
Caudate	expressed_in	brain_region	0.55
Neuron	expressed_in	cell_type	0.55
Microglia	expressed_in	cell_type	0.55
NEURON	co_discussed	gene	0.50
disease	inhibits	disease	0.50

Incoming (33)

Source	Relation	Type	Str
NF-ΚB1	downregulates	gene	0.80
NRF2	therapeutic_target	gene	0.60
NRF2	biomarker_for	gene	0.60
PLCG2	biomarker_for	gene	0.60
NFE2L2	biomarker_for	gene	0.60
TNF	therapeutic_target	gene	0.60
PLCG2	therapeutic_target	gene	0.60
NFE2L2	therapeutic_target	gene	0.60
ARG1	activates	gene	0.60
CHI3L1	activates	gene	0.60
MMP9	activates	gene	0.60
HBB	activates	gene	0.60
NEUROINFLAMMATION	biomarker_for	gene	0.60
MITOCHONDRIAL DYSFUNCTION	biomarker_for	gene	0.60
INFLAMMATION	biomarker_for	gene	0.60
PARKINSON	biomarker_for	gene	0.60
ALZHEIMER	biomarker_for	gene	0.60
NF-ΚB	biomarker_for	gene	0.60
OXIDATIVE STRESS	biomarker_for	gene	0.60
RNA	inhibits	gene	0.60
AND	inhibits	gene	0.60
ALZHEIMER'S DISEASE	biomarker_for	gene	0.60
PARKINSON'S DISEASE	biomarker_for	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
PARKINSON	therapeutic_target	gene	0.60
IL-10	activates	gene	0.60
LCN2	activates	gene	0.60
IL-17	activates	gene	0.60
IL-18	expressed_in	gene	0.60
ERBB2	activates	gene	0.60
PD-L1	activates	gene	0.60
ALZHEIMER	activates	gene	0.50
NF-ΚB	activates	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found