concept

IL-17

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IL-17: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

576Connections

1Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	IL-17
Key Genes/Proteins	Actin, Akt, AKT, AKT1, Alpha-Synuclein, ALZHEIMER
Related Diseases	Aging, Als, ALS, Alzheimer
Related Pathways	Amyloid

Pathway Diagram

graph TD
    IL_17["IL-17"]
    IL_17 -->|"mediates"| Myeloid_Cell_Immune_Response["Myeloid Cell Immune Response"]
    IL_17 -->|"mediates"| Neuroinflammation["Neuroinflammation"]
    IL_17 -->|"promotes"| hidradenitis_suppurativa["hidradenitis suppurativa"]
    IL_17 -->|"co_expressed_with"| IL_1["IL-1"]
    IL_17 -.biomarker for.-> Rheumatoid_Arthritis["Rheumatoid Arthritis"]
    IL_17 -->|"activates"| TNF["TNF"]
    IL_17 -->|"inhibits"| IL_6["IL-6"]
    Neutrophils["Neutrophils"] -->|"expressed in"| IL_17
    Microglia["Microglia"] -->|"expressed in"| IL_17
    APOPTOSIS["APOPTOSIS"] -->|"activates"| IL_17
    CYTOKINES["CYTOKINES"] -->|"inhibits"| IL_17
    CASP3["CASP3"] -->|"activates"| IL_17
    ASTROCYTES["ASTROCYTES"] -->|"activates"| IL_17

Outgoing (336)

Target	Relation	Type	Str
Cognitive Impairment	associated_with	phenotype	0.85
hidradenitis suppurativa	promotes	disease	0.85
Neuroinflammation	mediates	process	0.85
Myeloid Cell Immune Response	mediates	process	0.85
IL-1	interacts_with	protein	0.80
Rheumatoid Arthritis	biomarker_for	disease	0.80
Autoimmune Diseases	associated_with	disease	0.80
MICROGLIA	upregulates	cell_type	0.80
INFLAMMATION	associated_with	process	0.80
skeletal muscle inflammation	mediates	process	0.70
ALS	causes	disease	0.65
Inflammation	inhibits	disease	0.65
ALS	expressed_in	disease	0.65
Inflammation	activates	disease	0.65
Als	activates	disease	0.65
ALS	inhibits	disease	0.65
Dementia	interacts_with	disease	0.65
Dementia	expressed_in	disease	0.65
Aging	activates	disease	0.65
Amyotrophic Lateral Sclerosis	therapeutic_target	disease	0.65
TNF	activates	gene	0.65
Als	expressed_in	disease	0.65
Multiple Sclerosis	activates	disease	0.65
Dementia	therapeutic_target	disease	0.65
Als	inhibits	disease	0.65
Ferroptosis	activates	disease	0.65
Stroke	expressed_in	disease	0.65
Vascular Dementia	expressed_in	disease	0.65
Als	regulates	disease	0.65
Cirrhosis	activates	disease	0.65
Als	therapeutic_target	disease	0.65
Inflammation	interacts_with	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Amyotrophic Lateral Sclerosis	activates	disease	0.65
TNF	inhibits	gene	0.65
Parkinson	associated_with	disease	0.65
ALS	associated_with	disease	0.65
Ferroptosis	therapeutic_target	disease	0.65
Autoimmune	activates	disease	0.65
Multiple Sclerosis	therapeutic_target	disease	0.65
IL-6	inhibits	gene	0.65
Neuroinflammation	therapeutic_target	disease	0.65
ALS	regulates	disease	0.65
Inflammation	regulates	disease	0.65
Heart Failure	regulates	disease	0.65
Neuroinflammation	inhibits	disease	0.65
Tumor	activates	disease	0.65
Alzheimer	activates	disease	0.65
Als	associated_with	disease	0.65
Neuroinflammation	activates	disease	0.65

Incoming (240)

Source	Relation	Type	Str
Neutrophils	expressed_in	cell_type	0.85
Microglia	expressed_in	cell_type	0.85
TRIPTOLIDE	inhibits	compound	0.80
blood-brain barrier permeability	activates	process	0.70
MMP12	inhibits	gene	0.60
S100A9	activates	gene	0.60
TNF	activates	gene	0.60
GENES	activates	gene	0.60
MMP9	associated_with	gene	0.60
ASTROCYTE	activates	gene	0.60
S100A8	activates	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
INFLAMMATION	interacts_with	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	activates	gene	0.60
IL-1	interacts_with	gene	0.60
MMP9	therapeutic_target	gene	0.60
IL-6	associated_with	gene	0.60
JAK	activates	gene	0.60
APOE4	associated_with	gene	0.60
CXCL8	associated_with	gene	0.60
IL1B	associated_with	gene	0.60
MMP9	activates	gene	0.60
NEUROINFLAMMATION	inhibits	gene	0.60
AMYLOID	activates	gene	0.60
IL-1	inhibits	gene	0.60
CASP3	therapeutic_target	gene	0.60
IL1B	therapeutic_target	gene	0.60
STROKE	expressed_in	gene	0.60
ROS	therapeutic_target	gene	0.60
IL-23	therapeutic_target	gene	0.60
CLDN5	therapeutic_target	gene	0.60
ALZHEIMER	activates	gene	0.60
AMYLOID	therapeutic_target	gene	0.60
NRF2	activates	gene	0.60
IL-22	inhibits	gene	0.60
P2RX7	activates	gene	0.60
NAD	activates	gene	0.60
APOE	associated_with	gene	0.60
NF-ΚB	activates	gene	0.60
APOE Ε4	activates	gene	0.60
GENES	expressed_in	gene	0.60
INFLAMMATION	inhibits	gene	0.60
TNF	inhibits	gene	0.60
IL-6	inhibits	gene	0.60
TLR4	inhibits	gene	0.60
IL6	regulates	gene	0.60
MLKL	interacts_with	gene	0.60
MYD88	inhibits	gene	0.60
NLRP3	associated_with	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Colonic Th17/IL-17A Axis → Peripheral Immune Recruitment to	0.640	neurodegeneration	What are the mechanisms by which gut mic

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning IL-17 in their description or question text

No additional research found