Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PREFRONTAL: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | PREFRONTAL |
| Key Genes/Proteins | SOD1, C9ORF72, FUS |
| Related Diseases | ALS, PTSD |
| Linked Hypotheses | 8 hypotheses |
Knowledge base pages for this entity
graph TD
PREFRONTAL["PREFRONTAL"]
PREFRONTAL -->|"regulates"| SOD1["SOD1"]
PREFRONTAL -->|"regulates"| PTSD["PTSD"]
PREFRONTAL -->|"causes"| SUBSTANTIA_NIGRA["SUBSTANTIA NIGRA"]
PREFRONTAL -->|"causes"| VENTRAL_TEGMENTAL["VENTRAL TEGMENTAL"]
ALS["ALS"] -->|"regulates"| PREFRONTAL
C9ORF72["C9ORF72"] -->|"regulates"| PREFRONTAL
FUS["FUS"] -->|"regulates"| PREFRONTAL
AMYLOID["AMYLOID"] -->|"reduces"| PREFRONTAL
HIPPOCAMPUS["HIPPOCAMPUS"] -->|"contributes to"| PREFRONTAL
FRONTAL["FRONTAL"] -->|"sensitizes_to"| PREFRONTAL
CORTEX["CORTEX"] -->|"regulates"| PREFRONTAL| Target | Relation | Type | Str |
|---|---|---|---|
| SOD1 | regulates | gene | 0.65 |
| PTSD | regulates | disease | 0.60 |
| SUBSTANTIA NIGRA | causes | brain_region | 0.60 |
| VENTRAL TEGMENTAL | causes | brain_region | 0.60 |
| PTSD | co_discussed | disease | 0.40 |
| SYNAPTIC TRANSMISSION | co_discussed | biological_process | 0.40 |
| SCHIZOPHRENIA | co_discussed | disease | 0.40 |
| STRIATUM | co_discussed | brain_region | 0.40 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ALS | regulates | disease | 0.65 |
| C9ORF72 | regulates | gene | 0.65 |
| FUS | regulates | gene | 0.65 |
| HIPPOCAMPUS | contributes_to | brain_region | 0.65 |
| ALS | sensitizes_to | disease | 0.65 |
| FRONTAL | sensitizes_to | brain_region | 0.65 |
| CORTEX | regulates | brain_region | 0.65 |
| FRONTAL | contributes_to | brain_region | 0.65 |
| CORTEX | expressed_in | brain_region | 0.60 |
| FRONTAL | expressed_in | brain_region | 0.60 |
| CORTEX | associated_with | brain_region | 0.60 |
| FRONTAL | associated_with | brain_region | 0.60 |
| HIPPOCAMPUS | associated_with | brain_region | 0.60 |
| DEMENTIA | regulates | disease | 0.60 |
| NEURON | expressed_in | cell_type | 0.60 |
| NEURONS | expressed_in | cell_type | 0.60 |
| CORTEX | contributes_to | brain_region | 0.60 |
| NEURON | contributes_to | cell_type | 0.60 |
| FRONTAL | regulates | brain_region | 0.60 |
| HIPPOCAMPUS | regulates | brain_region | 0.60 |
| CORTEX | activates | brain_region | 0.60 |
| DEPRESSION | activates | disease | 0.60 |
| FRONTAL | activates | brain_region | 0.60 |
| MICROGLIA | expressed_in | cell_type | 0.60 |
| AMYGDALA | regulates | brain_region | 0.60 |
| INTERNEURON | activates | cell_type | 0.60 |
| INTERNEURONS | activates | cell_type | 0.60 |
| NEURON | activates | cell_type | 0.60 |
| NEURONS | activates | cell_type | 0.60 |
| CORTEX | inhibits | brain_region | 0.60 |
| FRONTAL | inhibits | brain_region | 0.60 |
| INTERNEURON | inhibits | cell_type | 0.60 |
| INTERNEURONS | inhibits | cell_type | 0.60 |
| NEURON | inhibits | cell_type | 0.60 |
| NEURONS | inhibits | cell_type | 0.60 |
| CHRNA7 | expressed_in | gene | 0.60 |
| CORTEX | causes | brain_region | 0.60 |
| DOPAMINERGIC | causes | cell_type | 0.60 |
| FRONTAL | causes | brain_region | 0.60 |
| ANXIETY | expressed_in | disease | 0.60 |
| DEPRESSION | expressed_in | disease | 0.60 |
| CORTEX | mediates | brain_region | 0.60 |
| DRD2 | mediates | gene | 0.60 |
| FRONTAL | mediates | brain_region | 0.60 |
| DRD2 | regulates | gene | 0.60 |
| GFAP | activates | gene | 0.60 |
| CORTEX | co_discussed | entity | 0.50 |
| HIPPOCAMPUS | co_discussed | entity | 0.50 |
| DEMENTIA | co_discussed | entity | 0.50 |
| DLB | co_discussed | entity | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Closed-loop transcranial alternating current stimulation to | 0.639 | Alzheimer's disease | Circuit-level neural dynamics in neurode |
| Prefrontal sensory gating circuit restoration via PV interne | 0.587 | Alzheimer's disease | Circuit-level neural dynamics in neurode |
| Real-time gamma-guided transcranial focused ultrasound targe | 0.538 | Alzheimer's disease | Circuit-level neural dynamics in neurode |
| Closed-loop transcranial focused ultrasound targeting CA1 PV | 0.508 | Alzheimer's disease | Circuit-level neural dynamics in neurode |
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Transcriptional and functional profiles of muscarinic receptor-expressing neuron [PMID:41857244] | Tsolias A, Mojica CA, Yamani R, Khanna S | Communications biology | 2026 | 0 |
| Neurophysiological and neuropharmacological effects of melatonin MT2 receptors a [PMID:41571206] | ["Barzon B", "Marchiotto F", "Nasini S", | Biochemical pharmacology | 2026 | 0 |
| Enhanced interhemispheric functional connectivity in elderly anxiety patients wi [PMID:41656398] | ["Chang Y", "Liu M", "Liu Y", "Xie X", " | Scientific reports | 2026 | 0 |
| Convergent transcriptomic and connectomic controllers of information integration [PMID:41606107] | Luppi AI, Uhrig L, Tasserie J, Mediano P | Nature human behaviour | 2026 | 0 |
| Transcranial direct current stimulation restores addictive behavior via prefront [PMID:41136747] | ["Zuo H", "Zhang W", "Wang L", "Wu Y", " | Molecular psychiatry | 2026 | 0 |
| Meta-Analyses of Auditory Evoked Potentials as Alzheimer Biomarkers. [PMID:40836165] | Bayat A, Mirmomeni G, Aiken S, Jafari Z | Ear and hearing | 2026 | 0 |
| Establishing mouse forebrain organoids as models of intrinsic cortical network a [PMID:41791384] | Hernandez S, Schweiger HE, Cline I, Kaur | Stem cell reports | 2026 | 0 |
| Altered Expression of GABA-Related Genes in Schizophrenia: Insights from Meta-An [PMID:41788138] | Singer Y, Yitzhaky A, Hertzberg L | Alpha psychiatry | 2026 | 0 |
| A silent Kv channel subunit shapes PV neuron action potential waveform and short [PMID:41632839] | Ganesh S, Canty TM, Sabatini BL | Proceedings of the National Ac | 2026 | 0 |
| External fixation versus reverse shoulder arthroplasty for proximal humerus frac [PMID:41940987] | Vadalà A, Benelli C, Suraci F, Carta B, | Arch Orthop Trauma Surg | 2026 | 0 |
| Mitochondrial bioenergetic signatures differentiate asymptomatic from symptomati [PMID:41279752] | Mandal P, Trushina E, Arnold M, Kaddurah | bioRxiv : the preprint server | 2025 | 0 |
| Multimodal Neuroimaging of Obesity: From Structural-Functional Mechanisms to Pre [PMID:40426616] | ["Liu W", "Li N", "Tang D", "Qin L", "Zh | Brain sciences | 2025 | 0 |
| Medial prefrontal cortex circuit dynamics involved in stage-specific addiction. [PMID:41307570] | ["Zhao D", "Zhang X", "Bai J"] | Brain structure & function | 2025 | 0 |
| Studies in rats of a target specific and reversible general anesthetic with a fa [PMID:41187127] | ["Xie Z", "Fong R", "Fox A"] | PloS one | 2025 | 0 |
| tDCS-induced enhancement of cognitive flexibility in autism: role of frontal lob [PMID:40874060] | ["Han Y", "Dong A", "Xia C", "Zhang Z", | Frontiers in behavioral neuros | 2025 | 0 |
| Fate plasticity of interneuron specification. [PMID:40264797] | ["Mostajo-Radji M", "Leon W", "Breevoort | iScience | 2025 | 0 |
| The thalamic reticular nucleus orchestrates social memory. [PMID:38701789] | Wang F, Sun H, Chen M, Feng B, Lu Y, Lyu | Neuron | 2024 | 0 |
| Integrated multimodal cell atlas of Alzheimer's disease. [PMID:39402379] | Gabitto MI, Travaglini KJ, Rachleff VM, | Nature neuroscience | 2024 | 0 |
| A vagal reflex evoked by airway closure. [PMID:38448588] | ["Schappe M", "Brinn P", "Joshi N", "Gre | Nature | 2024 | 0 |
| Parvalbumin interneuron mGlu [PMID:38773314] | ["Fabian C", "Jordan N", "Cole R", "Carl | Neuropsychopharmacology : offi | 2024 | 0 |