disease

Arrhythmia

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Arrhythmia: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

147Connections

0Hypotheses

0Analyses

32Outgoing

50Incoming

No summary available yet. View on Wiki →

Disease Info

Associated Genes	MITOCHONDRIA, MITOCHONDRIAL DYSFUNCTION, MITOPHAGY, STROKE, INSULIN RESISTANCE, INFLAMMATION, AGING, EXOSOMES
KG Connections	147 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    Arrhythmia["Arrhythmia"] -->|"activates"| Pi3K_Akt["Pi3K/Akt"]
    Arrhythmia["Arrhythmia"] -->|"activates"| Ampk_Signaling["Ampk Signaling"]
    Arrhythmia["Arrhythmia"] -->|"therapeutic target"| Mitochondrial_Function["Mitochondrial Function"]
    Arrhythmia["Arrhythmia"] -->|"therapeutic target"| Mitophagy["Mitophagy"]
    Arrhythmia["Arrhythmia"] -->|"therapeutic target"| Oxidative_Phosphorylation["Oxidative Phosphorylation"]
    Arrhythmia["Arrhythmia"] -->|"implicated in"| Mitophagy_1["Mitophagy"]
    Als["Als"] -->|"therapeutic target"| Arrhythmia["Arrhythmia"]
    MITOCHONDRIA["MITOCHONDRIA"] -->|"therapeutic target"| Arrhythmia["Arrhythmia"]
    PI3K["PI3K"] -->|"activates"| Arrhythmia["Arrhythmia"]
    AMPK["AMPK"] -->|"activates"| Arrhythmia["Arrhythmia"]
    style Arrhythmia fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (32)

Target	Relation	Type	Str
Sudden Unexpected Death in Epilepsy	contributes_to	disease	0.85
Pi3K/Akt	activates	pathway	0.60
Ampk Signaling	activates	pathway	0.60
Mitochondrial Function	therapeutic_target	pathway	0.60
Mitophagy	therapeutic_target	pathway	0.60
Oxidative Phosphorylation	therapeutic_target	pathway	0.60
Mitophagy	implicated_in	pathway	0.60
Microbiota	regulates	pathway	0.60
Cholesterol	regulates	pathway	0.60
Lipid Metabolism	regulates	pathway	0.60
Receptor Tyrosine Kinase	activates	pathway	0.60
Stem Cell	activates	pathway	0.60
Epigenetic	treats	pathway	0.60
Oxidative Stress	contributes_to	pathway	0.60
Mitochondrial Function	contributes_to	pathway	0.60
Checkpoint Inhibitor	inhibits	pathway	0.60
Immune Checkpoint	inhibits	pathway	0.60
Telomere	associated_with	pathway	0.60
Stem Cell	associated_with	pathway	0.60
Senescence	associated_with	pathway	0.60
Microbiota	activates	pathway	0.60
Oxidative Stress	regulates	pathway	0.60
Oxidative Stress	activates	pathway	0.60
Lipid Metabolism	activates	pathway	0.60
Inflammasome	activates	pathway	0.60
Apoptosis	associated_with	pathway	0.60
Tumor	regulates	disease	0.55
Cardiovascular	regulates	disease	0.55
Atherosclerosis	regulates	disease	0.55
Cardiovascular	therapeutic_target	disease	0.55
Als	activates	disease	0.55
Cardiovascular	activates	disease	0.55

Incoming (115)

Source	Relation	Type	Str
Long-Qt Syndrome	causes	disease	0.90
Long QT Syndrome	causes	disease	0.90
Seizure	associated_with	phenotype	0.82
Seizures	associated_with	phenotype	0.80
Als	therapeutic_target	disease	0.75
MITOCHONDRIA	therapeutic_target	gene	0.75
PI3K	activates	gene	0.65
AMPK	activates	gene	0.65
VEGF	activates	gene	0.65
AKT	activates	gene	0.65
EXOSOMES	activates	gene	0.65
Myocardial Infarction	activates	disease	0.65
Cardiac	inhibits	disease	0.65
TNF	regulates	gene	0.65
EXERCISE	regulates	gene	0.65
CYTOKINES	regulates	gene	0.65
VEGF	regulates	gene	0.65
TNF-Α	regulates	gene	0.65
ROS	therapeutic_target	gene	0.65
MITOPHAGY	therapeutic_target	gene	0.65
MITOCHONDRIAL DNA	therapeutic_target	gene	0.65
MTDNA	therapeutic_target	gene	0.65
MITOCHONDRIA	implicated_in	gene	0.65
MITOCHONDRIAL DYSFUNCTION	implicated_in	gene	0.65
DNA	therapeutic_target	gene	0.65
ATP	therapeutic_target	gene	0.65
Cardiac	therapeutic_target	disease	0.65
MITOPHAGY	implicated_in	gene	0.65
LDL	regulates	gene	0.65
APOE	regulates	gene	0.65
SREBP1	regulates	gene	0.65
SREBP2	regulates	gene	0.65
OVERVIEW	treats	gene	0.65
Cardiac	activates	disease	0.65
OXIDATIVE STRESS	contributes_to	gene	0.65
INFLAMMATION	contributes_to	gene	0.65
STROKE	associated_with	gene	0.65
INSULIN RESISTANCE	associated_with	gene	0.65
Cardiovascular	associated_with	disease	0.65
Heart Failure	associated_with	disease	0.65
CANCER	inhibits	gene	0.65
Atherosclerosis	associated_with	disease	0.65
INFLAMMATION	associated_with	gene	0.65
AGING	associated_with	gene	0.65
EXOSOMES	associated_with	gene	0.65
MITOCHONDRIAL DYSFUNCTION	associated_with	gene	0.65
EXERCISE	activates	gene	0.65
OXIDATIVE STRESS	regulates	gene	0.65
INFLAMMATION	regulates	gene	0.65
OVERVIEW	regulates	gene	0.65

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Arrhythmia

Understanding Entity Pages

Wiki Pages (20)

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