Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Multidrug Resistance: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | Multidrug Resistance |
| Key Genes/Proteins | CANCER, APOPTOSIS, PI3K, NF-ΚB, AKT |
| Related Diseases | Als, Cancer, Tumor, Carcinoma, Leukemia |
Knowledge base pages for this entity
graph TD
Als["Als"] -->|"therapeutic target"| Multidrug_Resistance["Multidrug Resistance"]
style Als fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
CANCER["CANCER"] -->|"therapeutic target"| Multidrug_Resistance["Multidrug Resistance"]
style CANCER fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
Tumor["Tumor"] -->|"therapeutic target"| Multidrug_Resistance["Multidrug Resistance"]
style Tumor fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
APOPTOSIS["APOPTOSIS"] -->|"regulates"| Multidrug_Resistance["Multidrug Resistance"]
style APOPTOSIS fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
PI3K["PI3K"] -->|"regulates"| Multidrug_Resistance["Multidrug Resistance"]
style PI3K fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
style Multidrug_Resistance fill:#1b5e20,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| Als | therapeutic_target | disease | 1.00 |
| CANCER | therapeutic_target | gene | 0.90 |
| Cancer | therapeutic_target | disease | 0.90 |
| Tumor | therapeutic_target | disease | 0.90 |
| APOPTOSIS | regulates | gene | 0.70 |
| PI3K | regulates | gene | 0.70 |
| NF-ΚB | regulates | gene | 0.70 |
| CANCER | regulates | gene | 0.70 |
| AKT | regulates | gene | 0.70 |
| Cancer | regulates | disease | 0.70 |
| Als | activates | disease | 0.70 |
| Carcinoma | therapeutic_target | disease | 0.70 |
| NF-ΚB | therapeutic_target | gene | 0.70 |
| Leukemia | therapeutic_target | disease | 0.70 |
| AKT | therapeutic_target | gene | 0.70 |
| MYC | therapeutic_target | gene | 0.70 |
| GENES | activates | gene | 0.70 |
| CANCER | activates | gene | 0.70 |
| Cancer | activates | disease | 0.70 |
| AUTOPHAGY | therapeutic_target | gene | 0.60 |
| NEURODEGENERATION | therapeutic_target | gene | 0.60 |
| Neurodegeneration | therapeutic_target | disease | 0.60 |
| REST | therapeutic_target | gene | 0.60 |
| APOPTOSIS | therapeutic_target | gene | 0.60 |
| Cardiovascular | therapeutic_target | disease | 0.60 |
| GENES | regulates | gene | 0.60 |
| ASTROCYTE | therapeutic_target | gene | 0.60 |
| OVERVIEW | therapeutic_target | gene | 0.60 |
| SND1 | therapeutic_target | gene | 0.60 |
| Glioma | therapeutic_target | disease | 0.60 |
| STATHMIN | therapeutic_target | gene | 0.60 |
| CYTOKINES | therapeutic_target | gene | 0.60 |
| ABCB1 | therapeutic_target | gene | 0.60 |
| CANCER | inhibits | gene | 0.60 |
| MICROTUBULES | therapeutic_target | gene | 0.60 |
| Cancer | inhibits | disease | 0.60 |
| Tumor | treats | disease | 0.60 |
| Hepatocellular Carcinoma | therapeutic_target | disease | 0.60 |
| Breast Cancer | therapeutic_target | disease | 0.60 |
| PPAR | therapeutic_target | gene | 0.60 |
| EXOSOMES | therapeutic_target | gene | 0.60 |
| PI3K | therapeutic_target | gene | 0.60 |
| OCT4 | therapeutic_target | gene | 0.60 |
| KLF4 | therapeutic_target | gene | 0.60 |
| SOX2 | therapeutic_target | gene | 0.60 |
| JAK | therapeutic_target | gene | 0.60 |
| MTOR | therapeutic_target | gene | 0.60 |
| Tumor | contributes_to | disease | 0.60 |
| CD44 | therapeutic_target | gene | 0.60 |
| EGFR | activates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||