NFATC1

Understanding Entity Pages

This page aggregates everything SciDEX knows about NFATC1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

NFATC1 encodes a calcium-dependent transcription factor that regulates immune response, synaptic plasticity, and is implicated in neurodegenerative diseases

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graph TD
    NFATC1["<b>NFATC1</b>"]
    TRPC6["TRPC6"]
    NFATC1 -->|"activates"| TRPC6
    Ms{"Ms"}
    NFATC1 -->|"inhibits"| Ms
    Als{"Als"}
    NFATC1 -->|"activates"| Als
    NFATC1 -->|"regulates"| Ms
    SLC7A11["SLC7A11"]
    NFATC1 -->|"activates"| SLC7A11
    Apoptosis(["Apoptosis"])
    NFATC1 -->|"inhibits"| Apoptosis
    Autophagy(["Autophagy"])
    NFATC1 -->|"inhibits"| Autophagy
    Ferroptosis(["Ferroptosis"])
    NFATC1 -->|"inhibits"| Ferroptosis
    Necroptosis(["Necroptosis"])
    NFATC1 -->|"inhibits"| Necroptosis
    Calcium_Signaling(["Calcium Signaling"])
    NFATC1 -->|"activates"| Calcium_Signaling
    MST1["MST1"]
    NFATC1 -->|"activates"| MST1
    YAP["YAP"]
    NFATC1 -->|"regulates"| YAP
    PIEZO1["PIEZO1"]
    PIEZO1 -->|"activates"| NFATC1
    RANKL["RANKL"]
    RANKL -->|"activates"| NFATC1
    TXNRD1["TXNRD1"]
    TXNRD1 -->|"activates"| NFATC1
    FERROPTOSIS["FERROPTOSIS"]
    FERROPTOSIS -->|"inhibits"| NFATC1
    APOPTOSIS["APOPTOSIS"]
    APOPTOSIS -->|"inhibits"| NFATC1
    AUTOPHAGY["AUTOPHAGY"]
    AUTOPHAGY -->|"inhibits"| NFATC1
    AQP4["AQP4"]
    AQP4 -->|"regulates"| NFATC1
    GATA3["GATA3"]
    GATA3 -->|"regulates"| NFATC1
    GATA2["GATA2"]
    GATA2 -->|"regulates"| NFATC1
    HIPPO["HIPPO"]
    HIPPO -->|"activates"| NFATC1
    RANKL -->|"inhibits"| NFATC1
    PI3K["PI3K"]
    PI3K -->|"inhibits"| NFATC1
    style NFATC1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0