gene

GATA3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GATA3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

106Connections
0Hypotheses
0Analyses
50Outgoing
38Incoming
0Experiments

Summary

GATA3 is a gene implicated in neurodegeneration research. Key relationships include: associated with, regulates, activates. Associated with Als, Alzheimer, Asthma. Connected to 70 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolGATA3
Full NameGATA Binding Protein 3
AliasesPage for GATA3
Protein TypeTranscription Factor
FunctionGATA3 plays diverse roles in development and adult neural function
Primary Expressionhypothalamic neurons and regulates neuroendocrine functions
PathwaysDifferentiation, Hippo Pathway
Ensembl IDENSG00000107485
GeneCardsGATA3
Human Protein AtlasGATA3
Associated DiseasesAls, Alzheimer, Asthma, Autoimmune, Cancer, Carcinoma
InteractionsGATA2, MST1, TLR4, FOXP3, AQP4, HIPPO
KG Connections106 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

GATA3 - GATA Binding Protein 3

gene · 502 words

Neurons — Cell Type Hierarchy

cell · 5551 words

CCR8 Gene

gene · 2904 words

GABAergic Neurons — Cell Type Hierarchy

cell · 2527 words

IL13 — Interleukin 13

gene · 2501 words

TBX1 — T-Box Transcription Factor 1

gene · 2492 words

Pathway Diagram

graph TD
    GATA3["<b>GATA3</b>"]
    Als{"Als"}
    GATA3 -->|"activates"| Als
    Ms{"Ms"}
    GATA3 -->|"regulates"| Ms
    Cancer{"Cancer"}
    GATA3 -->|"regulates"| Cancer
    Tumor{"Tumor"}
    GATA3 -->|"regulates"| Tumor
    Hepatitis{"Hepatitis"}
    GATA3 -->|"associated with"| Hepatitis
    Glioblastoma{"Glioblastoma"}
    GATA3 -->|"associated with"| Glioblastoma
    Alzheimer{"Alzheimer"}
    GATA3 -->|"associated with"| Alzheimer
    Obesity{"Obesity"}
    GATA3 -->|"associated with"| Obesity
    Diabetes{"Diabetes"}
    GATA3 -->|"associated with"| Diabetes
    Stroke{"Stroke"}
    GATA3 -->|"associated with"| Stroke
    Multiple_Sclerosis{"Multiple Sclerosis"}
    GATA3 -->|"associated with"| Multiple_Sclerosis
    GATA3 -->|"associated with"| Als
    AQP4["AQP4"]
    AQP4 -->|"activates"| GATA3
    TGFB1["TGFB1"]
    TGFB1 -->|"regulates"| GATA3
    TGFBR2["TGFBR2"]
    TGFBR2 -->|"regulates"| GATA3
    RORA["RORA"]
    RORA -->|"associated with"| GATA3
    CANCER["CANCER"]
    CANCER -->|"associated with"| GATA3
    BMP7["BMP7"]
    BMP7 -->|"associated with"| GATA3
    CX3CR1["CX3CR1"]
    CX3CR1 -->|"associated with"| GATA3
    CYTOKINES["CYTOKINES"]
    CYTOKINES -->|"associated with"| GATA3
    DIABETES_MELLITUS["DIABETES MELLITUS"]
    DIABETES_MELLITUS -->|"associated with"| GATA3
    AHR["AHR"]
    AHR -->|"associated with"| GATA3
    MICRORNAS["MICRORNAS"]
    MICRORNAS -->|"associated with"| GATA3
    EP300["EP300"]
    EP300 -->|"associated with"| GATA3
    style GATA3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (68)

TargetRelationTypeStr
Alsactivatesdisease0.65
Msregulatesdisease0.65
Cancerregulatesdisease0.65
Tumorregulatesdisease0.65
Hepatitisassociated_withdisease0.65

Incoming (38)

SourceRelationTypeStr
AQP4activatesgene0.60
TGFB1regulatesgene0.60
TGFBR2regulatesgene0.60
RORAassociated_withgene0.60
BMP7associated_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

ExperimentTypeDiseaseScoreFeasibilityModelStatusEst. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found