Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about GATA3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
GATA3 is a gene implicated in neurodegeneration research. Key relationships include: associated with, regulates, activates. Associated with Als, Alzheimer, Asthma. Connected to 70 entities in the SciDEX knowledge graph.
| Gene Symbol | GATA3 |
| Full Name | GATA Binding Protein 3 |
| Aliases | Page for GATA3 |
| Protein Type | Transcription Factor |
| Function | GATA3 plays diverse roles in development and adult neural function |
| Primary Expression | hypothalamic neurons and regulates neuroendocrine functions |
| Pathways | Differentiation, Hippo Pathway |
| Ensembl ID | ENSG00000107485 |
| GeneCards | GATA3 |
| Human Protein Atlas | GATA3 |
| Associated Diseases | Als, Alzheimer, Asthma, Autoimmune, Cancer, Carcinoma |
| Interactions | GATA2, MST1, TLR4, FOXP3, AQP4, HIPPO |
| KG Connections | 106 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
GATA3["<b>GATA3</b>"]
Als{"Als"}
GATA3 -->|"activates"| Als
Ms{"Ms"}
GATA3 -->|"regulates"| Ms
Cancer{"Cancer"}
GATA3 -->|"regulates"| Cancer
Tumor{"Tumor"}
GATA3 -->|"regulates"| Tumor
Hepatitis{"Hepatitis"}
GATA3 -->|"associated with"| Hepatitis
Glioblastoma{"Glioblastoma"}
GATA3 -->|"associated with"| Glioblastoma
Alzheimer{"Alzheimer"}
GATA3 -->|"associated with"| Alzheimer
Obesity{"Obesity"}
GATA3 -->|"associated with"| Obesity
Diabetes{"Diabetes"}
GATA3 -->|"associated with"| Diabetes
Stroke{"Stroke"}
GATA3 -->|"associated with"| Stroke
Multiple_Sclerosis{"Multiple Sclerosis"}
GATA3 -->|"associated with"| Multiple_Sclerosis
GATA3 -->|"associated with"| Als
AQP4["AQP4"]
AQP4 -->|"activates"| GATA3
TGFB1["TGFB1"]
TGFB1 -->|"regulates"| GATA3
TGFBR2["TGFBR2"]
TGFBR2 -->|"regulates"| GATA3
RORA["RORA"]
RORA -->|"associated with"| GATA3
CANCER["CANCER"]
CANCER -->|"associated with"| GATA3
BMP7["BMP7"]
BMP7 -->|"associated with"| GATA3
CX3CR1["CX3CR1"]
CX3CR1 -->|"associated with"| GATA3
CYTOKINES["CYTOKINES"]
CYTOKINES -->|"associated with"| GATA3
DIABETES_MELLITUS["DIABETES MELLITUS"]
DIABETES_MELLITUS -->|"associated with"| GATA3
AHR["AHR"]
AHR -->|"associated with"| GATA3
MICRORNAS["MICRORNAS"]
MICRORNAS -->|"associated with"| GATA3
EP300["EP300"]
EP300 -->|"associated with"| GATA3
style GATA3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Als | activates | disease | 0.65 |
| Ms | regulates | disease | 0.65 |
| Cancer | regulates | disease | 0.65 |
| Tumor | regulates | disease | 0.65 |
| Hepatitis | associated_with | disease | 0.65 |
| Glioblastoma | associated_with | disease | 0.65 |
| Alzheimer | associated_with | disease | 0.65 |
| Obesity | associated_with | disease | 0.65 |
| Diabetes | associated_with | disease | 0.65 |
| Stroke | associated_with | disease | 0.65 |
| Multiple Sclerosis | associated_with | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Cancer | associated_with | disease | 0.65 |
| Carcinoma | associated_with | disease | 0.65 |
| Fibrosis | associated_with | disease | 0.65 |
| Ms | associated_with | disease | 0.65 |
| Leukemia | associated_with | disease | 0.65 |
| Autoimmune | associated_with | disease | 0.65 |
| Asthma | associated_with | disease | 0.65 |
| Inflammation | activates | disease | 0.65 |
| Tumor | expressed_in | disease | 0.65 |
| Cancer | expressed_in | disease | 0.65 |
| Als | treats | disease | 0.65 |
| Inflammation | treats | disease | 0.65 |
| GATA2 | activates | gene | 0.60 |
| NFATC1 | regulates | gene | 0.60 |
| MST1 | activates | gene | 0.60 |
| ATF6 | associated_with | gene | 0.60 |
| MAF | associated_with | gene | 0.60 |
| BCL2 | expressed_in | gene | 0.60 |
| TLR4 | activates | gene | 0.60 |
| FOXP3 | activates | gene | 0.60 |
| AQP4 | activates | gene | 0.60 |
| NLRP3 | expressed_in | gene | 0.60 |
| GLB1 | regulates | gene | 0.60 |
| IL1RL1 | regulates | gene | 0.60 |
| IL4 | regulates | gene | 0.60 |
| IL7R | regulates | gene | 0.60 |
| LC3 | regulates | gene | 0.60 |
| LDH | regulates | gene | 0.60 |
| PECAM1 | regulates | gene | 0.60 |
| RORC | regulates | gene | 0.60 |
| SQSTM1 | regulates | gene | 0.60 |
| TNF | regulates | gene | 0.60 |
| VIM | regulates | gene | 0.60 |
| HIPPO | activates | gene | 0.60 |
| YAP | regulates | gene | 0.60 |
| MST2 | activates | gene | 0.60 |
| CLDN4 | regulates | gene | 0.60 |
| CANCER | regulates | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| AQP4 | activates | gene | 0.60 |
| TGFB1 | regulates | gene | 0.60 |
| TGFBR2 | regulates | gene | 0.60 |
| RORA | associated_with | gene | 0.60 |
| BMP7 | associated_with | gene | 0.60 |
| CX3CR1 | associated_with | gene | 0.60 |
| AHR | associated_with | gene | 0.60 |
| EP300 | associated_with | gene | 0.60 |
| JUN | associated_with | gene | 0.60 |
| JAK2 | associated_with | gene | 0.60 |
| CCL20 | associated_with | gene | 0.60 |
| CD38 | associated_with | gene | 0.60 |
| FOXP3 | associated_with | gene | 0.60 |
| PPARG | associated_with | gene | 0.60 |
| NOTCH1 | associated_with | gene | 0.60 |
| SMAD6 | associated_with | gene | 0.60 |
| FOXP2 | associated_with | gene | 0.60 |
| TP53 | expressed_in | gene | 0.60 |
| MST1 | activates | gene | 0.60 |
| ACTB | regulates | gene | 0.60 |
| BECN1 | regulates | gene | 0.60 |
| CD31 | regulates | gene | 0.60 |
| CKB | regulates | gene | 0.60 |
| CTS | regulates | gene | 0.60 |
| GAPDH | regulates | gene | 0.60 |
| CANCER | associated_with | gene | 0.60 |
| CYTOKINES | associated_with | gene | 0.60 |
| DIABETES MELLITUS | associated_with | gene | 0.60 |
| MICRORNAS | associated_with | gene | 0.60 |
| ALZHEIMER DISEASE | associated_with | gene | 0.60 |
| INFLAMMATION | activates | gene | 0.60 |
| INFLAMMATION | treats | gene | 0.60 |
| JAK | treats | gene | 0.60 |
| AND | expressed_in | gene | 0.60 |
| CYTOKINES | expressed_in | gene | 0.60 |
| AND | activates | gene | 0.60 |
| AQP3 | activates | gene | 0.60 |
| ANXA5 | regulates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||