Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about OPC: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | OPC |
| Linked Hypotheses | 1 hypotheses |
Knowledge base pages for this entity
graph TD
OPC["OPC"]
OPC -->|"expressed in"| White_Matter["White Matter"]
OPC -->|"expressed in"| Cortex["Cortex"]
OPC -->|"expressed in"| Hippocampus["Hippocampus"]
RNA["RNA"] -->|"regulates"| OPC
GPR37["GPR37"] -->|"regulates"| OPC
MYELIN["MYELIN"] -->|"regulates"| OPC
DEMENTIA["DEMENTIA"] -->|"interacts"| OPC
SERPINE2["SERPINE2"] -->|"activates"| OPC
TAUOPATHY["TAUOPATHY"] -->|"activates"| OPC
ASTROCYTE["ASTROCYTE"] -->|"activates"| OPC| Target | Relation | Type | Str |
|---|---|---|---|
| oligodendrocyte | associated_with | cell_type | 0.75 |
| Source | Relation | Type | Str |
|---|---|---|---|
| GPR37 | regulates | gene | 0.60 |
| LDLR | associated_with | gene | 0.60 |
| TAU | activates | gene | 0.60 |
| APOE | associated_with | gene | 0.60 |
| CD44 | expressed_in | gene | 0.60 |
| GBM | associated_with | gene | 0.60 |
| KCND2 | associated_with | gene | 0.60 |
| MTOR | expressed_in | gene | 0.60 |
| SLC12A5 | causes | gene | 0.60 |
| FLOT1 | causes | gene | 0.60 |
| RNA | regulates | gene | 0.60 |
| MYELIN | regulates | gene | 0.60 |
| RNA | interacts_with | gene | 0.60 |
| DEMENTIA | interacts_with | gene | 0.60 |
| SERPINE2 | activates | gene | 0.60 |
| TAUOPATHY | activates | gene | 0.60 |
| ASTROCYTE | activates | gene | 0.60 |
| MYELIN | associated_with | gene | 0.60 |
| MICROGLIA | activates | gene | 0.60 |
| ALZHEIMER | activates | gene | 0.60 |
| RNA | expressed_in | gene | 0.60 |
| STROKE | contributes_to | gene | 0.60 |
| ASTROCYTES | contributes_to | gene | 0.60 |
| EPILEPSY | associated_with | gene | 0.60 |
| GLIOBLASTOMA | activates | gene | 0.60 |
| ASTROCYTES | inhibits | gene | 0.60 |
| COP1 | causes | gene | 0.60 |
| MICROGLIA | inhibits | gene | 0.60 |
| Als | activates | disease | 0.55 |
| Vascular Dementia | interacts_with | disease | 0.55 |
| Ischemia | interacts_with | disease | 0.55 |
| Neurodegeneration | activates | disease | 0.55 |
| Als | regulates | disease | 0.55 |
| Als | expressed_in | disease | 0.55 |
| Cancer | associated_with | disease | 0.55 |
| Traumatic Brain Injury | expressed_in | disease | 0.55 |
| Ischemia | expressed_in | disease | 0.55 |
| Als | inhibits | disease | 0.55 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| OPC differentiation blockade contributes to white matter deg | 0.495 | Alzheimer's disease | SEA-AD Single-Cell Analysis: Cell-Type V |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-03 | 17 hypotheses Top: 0.662
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Cancer-Associated Fibroblasts Promote Imatinib Resistance in Gastrointestinal St [PMID:41270149] | Li C, Teng T, Lin X, Sun X, Yi T et al. | Cancer Res | 2026 | 0 |
| A cellular epigenetic classification system for glioblastoma. [PMID:41499453] | Silverbush D, Jürgensen L, Freeburg NF, | Neuro Oncol | 2026 | 0 |
| Gastrointestinal Stromal Tumors: Molecular Mechanisms of Drug Resistance and Adv [PMID:41724491] | Jingnuo D, Huachuan Z, Da Z, Zhi D, Yan | J Gastroenterol Hepatol | 2026 | 0 |
| P16(+) Cells Drive Adverse Postischemic Cardiac Remodeling Through CCL8-Mediated [PMID:41766526] | Yan L, Zheng J, Lu Z, Zhu A, Ye M et al. | Circulation | 2026 | 0 |
| Multi-omics reveals heterogeneity and functional populations of oligodendrocyte [PMID:41771834] | Ye D, Zhou H, Qu S, Wang Z, Zhang F et a | Cell Death Discov | 2026 | 0 |
| Comparison of gene fusion detection algorithms reveals frequently overlooked dri [PMID:41935182] | Tamura Z, Saito Y, Kogure Y, Oshikawa-Ku | NPJ Precis Oncol | 2026 | 0 |
| Single-cell transcriptome analysis indicated that immune-related programmed cell [PMID:41946148] | Sun J, Jing L, Zhu X, Yang H, Sun Y et a | Transl Oncol | 2026 | 0 |
| Lipid emulsion modulates myogenic and collagen-related gene expression in skelet [PMID:41955312] | Li X, Alaniz SM, Louey S, Deavila JM, Jo | Exp Physiol | 2026 | 0 |