concept

OLIGODENDROCYTE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about OLIGODENDROCYTE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1484Connections

16Hypotheses

13Analyses

50Outgoing

50Incoming

Summary

OLIGODENDROCYTE is a concept in neurodegeneration research. Key relationships include: associated with, activates, inhibits. Associated with ALS, Aging, Als. Connected to 369 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	OLIGODENDROCYTE
Key Genes/Proteins	MICROGLIA, ASTROCYTE, MYELIN
Related Diseases	Multiple Sclerosis, Inflammation, Als, Neuroinflammation, Autoimmune
Linked Hypotheses	16 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    OLIGODENDROCYTE["OLIGODENDROCYTE"]
    OLIGODENDROCYTE -->|"implicated in"| Alzheimer_s_disease["Alzheimer's disease"]
    OLIGODENDROCYTE -->|"regulates"| Myelin["Myelin"]
    OLIGODENDROCYTE -->|"regulates"| Aging["Aging"]
    OLIGODENDROCYTE -->|"activates"| Inflammation["Inflammation"]
    OLIGODENDROCYTE -->|"inhibits"| ALS["ALS"]
    OLIGODENDROCYTE -->|"inhibits"| Autoimmune["Autoimmune"]
    OLIGODENDROCYTE -->|"inhibits"| GPR37["GPR37"]
    OLIGODENDROCYTE -->|"inhibits"| Myelination["Myelination"]
    OLIGODENDROCYTE -->|"activates"| INFLAMMATION["INFLAMMATION"]
    MLKL["MLKL"] -->|"activates"| OLIGODENDROCYTE
    OPTN["OPTN"] -.protects against.-> OLIGODENDROCYTE
    AQUAPORIN_4["AQUAPORIN-4"] -.biomarker for.-> OLIGODENDROCYTE
    MYELIN["MYELIN"] -.biomarker for.-> OLIGODENDROCYTE
    MOG["MOG"] -.biomarker for.-> OLIGODENDROCYTE
    PHAGOCYTOSIS["PHAGOCYTOSIS"] -->|"activates"| OLIGODENDROCYTE
    BANG["BANG"] -->|"activates"| OLIGODENDROCYTE
    COMPLEMENT["COMPLEMENT"] -->|"causes"| OLIGODENDROCYTE
    AQP4["AQP4"] -->|"causes"| OLIGODENDROCYTE

Outgoing (594)

Target	Relation	Type	Str
MICROGLIA	activates	gene	0.90
Multiple Sclerosis	associated_with	disease	0.85
Inflammation	activates	disease	0.85
Als	activates	disease	0.85
Neuroinflammation	therapeutic_target	disease	0.85
Inflammation	therapeutic_target	disease	0.85
Multiple Sclerosis	therapeutic_target	disease	0.85
ASTROCYTE	activates	gene	0.80
MYELIN	associated_with	gene	0.80
Autoimmune	inhibits	disease	0.75
Neurodegeneration	activates	disease	0.75
Autoimmune	activates	disease	0.75
Inflammation	associated_with	disease	0.75
Dementia	inhibits	disease	0.75
Alzheimer	inhibits	disease	0.75
Als	therapeutic_target	disease	0.75
Stroke	therapeutic_target	disease	0.75
Differentiation	activates	pathway	0.70
AMYLOID-Β PLAQUES	inhibits	gene	0.70
MICROGLIA	inhibits	gene	0.70
AMYLOID	inhibits	gene	0.70
GENES	inhibits	gene	0.70
DEMENTIA	inhibits	gene	0.70
P53	inhibits	gene	0.70
NEURON	inhibits	gene	0.70
ALZHEIMER	inhibits	gene	0.70
ASTROCYTES	inhibits	gene	0.70
AKT	inhibits	gene	0.70
MTOR	inhibits	gene	0.70
Mtor	inhibits	pathway	0.70
Pi3K/Akt	inhibits	pathway	0.70
Wnt	inhibits	pathway	0.70
ASTROCYTES	associated_with	gene	0.70
MBP	activates	gene	0.70
NEUROINFLAMMATION	therapeutic_target	gene	0.70
Apoptosis	activates	pathway	0.70
AMYLOID	protects_against	protein	0.70
SENESCENCE	treats	phenotype	0.70
DEMYELINATION	treats	phenotype	0.70
DEMYELINATION	stabilizes	phenotype	0.70
OLIG2	stabilizes	gene	0.70
PLP1	associated_with	gene	0.65
TNF	associated_with	gene	0.65
Aging	regulates	disease	0.65
Cancer	associated_with	disease	0.65
ALS	inhibits	disease	0.65
Parkinson	associated_with	disease	0.65
Stroke	associated_with	disease	0.65
Alzheimer	associated_with	disease	0.65
Ischemia	interacts_with	disease	0.65

Incoming (890)

Source	Relation	Type	Str
NEURODEGENERATION	associated_with	gene	1.00
MICROGLIA	associated_with	gene	0.98
ASTROCYTES	associated_with	gene	0.98
ALZHEIMER'S DISEASE	associated_with	gene	0.90
COMPLEMENT CASCADE	causes	entity	0.90
MYELIN	activates	gene	0.90
MYELIN	associated_with	gene	0.75
NEUROINFLAMMATION	associated_with	gene	0.74
TAU	associated_with	protein	0.74
ASTROCYTE	associated_with	gene	0.70
MYELIN	inhibits	gene	0.70
NEURODEGENERATION	activates	gene	0.70
ASTROCYTE	activates	cell_type	0.70
NEURODEGENERATION	causes	disease	0.70
ASTROCYTE	regulates	cell_type	0.70
ASTROCYTES	regulates	cell_type	0.70
MOG	activates	gene	0.70
INFLAMMATION	activates	gene	0.70
MICROGLIAL ACTIVATION	activates	phenotype	0.70
MICROGLIAL ACTIVATION	stabilizes	phenotype	0.70
HK2	activates	gene	0.70
HK2	inhibits	gene	0.70
BMP4	produces	gene	0.70
HDAC3	treats	gene	0.70
HDAC3	inhibits	gene	0.70
HDAC3	regulates	gene	0.70
AMYLOID	associated_with	gene	0.66
APOPTOSIS	associated_with	gene	0.66
APP	associated_with	gene	0.66
JUN	associated_with	gene	0.66
MBP	associated_with	gene	0.65
MOG	associated_with	gene	0.65
OLIG2	associated_with	gene	0.65
HDAC3	associated_with	gene	0.65
CANCER	accumulates_in	disease	0.65
NEURON	accumulates_in	cell_type	0.65
MICROGLIA	mediates	cell_type	0.65
BIN1	causes	gene	0.65
GLUTAMATERGIC	expressed_in	cell_type	0.65
NEURON	causes	cell_type	0.65
DEMENTIA	activates	disease	0.65
IL-6	causes	gene	0.65
CORTEX	phosphorylates	brain_region	0.65
ASTROCYTE	contributes_to	cell_type	0.65
NEURONS	activates	cell_type	0.65
APOE2	activates	gene	0.65
APOE3	activates	gene	0.65
APOE4	activates	gene	0.65
NRF2	inhibits	gene	0.65
INTERNEURON	contributes_to	cell_type	0.65

Targeting Hypotheses (16)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
IL-6 Trans-Signaling Blockade at the Oligodendrocyte-Microgl	0.632	neuroinflammation	How do oligodendrocytes initiate neuroin
PDE4 Inhibition as Inflammatory Reset for PD Oligodendrocyte	0.576	neuroinflammation	How do oligodendrocytes initiate neuroin
ACSL4-Ferroptotic Priming in Stressed Oligodendrocytes Drive	0.512	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di
ACSL4-Driven Ferroptotic Priming in Disease-Associated Oligo	0.493	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di
ALOX15-Driven Enzymatic Ferroptosis in AD Oligodendrocytes v	0.491	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di

White Matter Oligodendrocyte Protection via CXCL10 Inhibitio	0.480	neurodegeneration	Gene expression changes in aging mouse b
Oligodendrocyte Remyelination Enhancement	0.474	neurodegeneration	Gene expression changes in aging mouse b
White Matter Vulnerability Prevention via Oligodendrocyte Pr	0.468	neurodegeneration	Gene expression changes in aging mouse b
Oligodendrocyte DNA Repair Enhancement Therapy	0.462	neurodegeneration	Cell type vulnerability in Alzheimer's D
BMP4 Pathway Inhibition for Oligodendrocyte Myelination Supp	0.454	neurodegeneration	Cell type vulnerability in Alzheimer's D
TREM2-Mediated Microglial Dysfunction Disrupts Oligodendrocy	0.452	neuroscience	Circuit-level neural dynamics in neurode
Oligodendrocyte Protectin D1 Mimetic for Myelin Resolution	0.447	neurodegeneration	Neuroinflammation resolution mechanisms
Oligodendrocyte-Targeted Myelin Sulfatide Restoration Therap	0.434	neurodegeneration	Which cell types show the most significa
Oligodendrocyte Progenitor Cell Metabolic Reprogramming	0.410	neurodegeneration	Which cell types show the most significa
Oligodendrocyte White Matter Vulnerability	0.398	neurodegeneration	Gene expression changes in aging mouse b
Oligodendrocyte DNA Repair Enhancement	0.378	neurodegeneration	Cell type vulnerability in Alzheimers Di

Mentioning Analyses (13)

Scientific analyses that reference this entity

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
METTL3/CXCL10 axis contributes to renal fibrosis by promoting the apoptosis of t [PMID:41138934]	Sun Y, Ren Z, Ge J, Zhang W, Shao F et a	Biochim Biophys Acta Mol Basis	2026
IL-25-ILC2-IL-13 axis improves traumatic brain injury by mediating CXCL-10-depen [PMID:41527095]	Peng M, Shu D, Chen Z, Yang Z, Zhang M e	J Neuroinflammation	2026
Oligodendrocyte transcription factor 2 orchestrates glioblastoma immune evasion [PMID:41591814]	Zhang X, Xue J, Zhao C, Zeng C, Zhong J	J Clin Invest	2026
Indole-3-propionic acid inhibits astrocyte inflammation and promotes motor funct [PMID:41663028]	Yu D, Kang J, Jiang W, Zhang C, Zhao X e	Neuropharmacology	2026
Cobrotoxin mitigates neuroinflammation and cognitive impairment by suppressing C [PMID:41671614]	Li Z, Tan B, Dong K, Yu X, Zhang SW et a	Biochem Pharmacol	2026
Peripheral macrophages and T-cells accumulate in the degenerating optic tract af [PMID:41740873]	Main BS, Villapol S, Buenaventura RG, Ha	Brain Behav Immun	2026
Melanoma cell inoculation improves cognitive impairment in the 5xFAD mouse model [PMID:41760781]	Bruna-Jara B, More J, Lobos P, Ponce DP,	Scientific reports	2026
Chemokine-defined macrophage niches establish spatial organization of tumor immu [PMID:41872505]	Ghosh S, Li X, Rawat K, Dighal A, Kalino	Nat Immunol	2026
Multi-omics analysis and experimental validation reveal the IRF7-CXCL10 axis as [PMID:41941036]	Lai Y, Lin P, Zhang K, Hong W, Zheng M e	Cell Biol Toxicol	2026
Primary Infection with Cystoisospora suis Modulates Systemic Immunity and the Gu [PMID:41942044]	Ye X, Huang YJ, Deng XL, He ZY, Tan JJ e	Int J Parasitol	2026
Agonists for cytosolic bacterial receptor ALPK1 induce antitumour immunity. [PMID:41372408]	Tian X, Liu J, Li Y, Wang Y, Luo Y, He H	Nature	2026
HTLV1-associated myelopathy as a translational model of progressive neurodegener [PMID:41926707]	da Silva MTT, Araujo AQC	Brain : a journal of neurology	2026
Unveiling the choroidal immune landscape revealed interferon-gamma and TNF-alpha [PMID:41077603]	Ye L, Zhao T, Tian H, Li R, Li Z et al.	Sci China Life Sci	2026
The mechanism of Qing-Fei-Yin decoction against influenza: Synergistical inhibit [PMID:41317805]	Nie W, Wang M, Cheng M, Ren Z, Liu G et	J Ethnopharmacol	2026
Elucidating the biological characteristics of overweight populations based on ur [PMID:41529508]	Li Y, Miao Y, Liang H, Zhou K, Li R et a	Spectrochim Acta A Mol Biomol	2026
Microenvironment-educated MSC-EVs loaded injectable smart hydrogel for targeting [PMID:41799958]	Wu W, Cheng Z, Shi P, Gao H, Chen X et a	Bioact Mater	2026
Genetic Variation in the Chemokine Network and Atherosclerosis Risk. [PMID:41824188]	Zangas P, Georgakis MK	Curr Atheroscler Rep	2026
Early repetitive transcranial magnetic stimulation for preventing chronic postop [PMID:41943114]	Zhou WW, Yang Z, Zhou C, Qiao Q, Zhang Y	BMC Med	2026
cGAMP Enhances Microglial/Macrophage Phagocytosis in Ischemic Stroke Via Activat [PMID:41495583]	["Li Xinyu", "Ding Huamin", "Qian Shuyu"	Inflammation	2026
The gain-of-function TREM2-T96K mutation increases risk for Alzheimer's disease [PMID:41109213]	Pilat DJ, Le H, Prokopenko D, Lin CJ, Ei	Neuron	2026

OLIGODENDROCYTE

Understanding Entity Pages

Summary

Wiki Pages (20)

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Clinical Management Guide for CBS/PSP

Progressive Supranuclear Palsy (PSP)

Novel Therapy Index

Pathway Diagram

Outgoing (594)

Incoming (890)

Targeting Hypotheses (16)

Mentioning Analyses (13)

What specific molecular mechanisms link APOE4 to cholesterol dysregulation in ol

What molecular mechanisms enable microglia to neutralize OxPC-mediated neurodege

How do oligodendrocytes initiate neuroinflammation in PD when microglia are trad

What specific gene expression signatures in aging mouse white matter predict hum

Is myelin loss in AD causal or an adaptive response to neuronal damage?

Senescent cell clearance as neurodegeneration therapy

Which cell types show the most significant expression changes for neurodegenerat

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

Cell type vulnerability in Alzheimer's Disease (SEA-AD data - v2)

Cell type vulnerability in Alzheimer's Disease (SEA-AD data - v2)

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

Related Papers (20)

OLIGODENDROCYTE

Understanding Entity Pages

Summary

Wiki Pages (20)

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Clinical Management Guide for CBS/PSP

Progressive Supranuclear Palsy (PSP)

Novel Therapy Index

Parkinson's Disease

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

primary-progressive-aphasia

calcium-dysregulation-comparison

Alpha-Synuclein Pathology

Corticobasal Degeneration (CBD)

Therapeutics

PI-2620 Tau PET in PSP

Section 162: Advanced Antioxidant and Redox Therapy in CBS/PSP

Neurons — Cell Type Hierarchy

neuroinflammation

GRIA3 Gene

NRF2 Oxidative Stress Pathway

Multiple System Atrophy

Alzheimer's Disease

Pathway Diagram

Outgoing (594)

Incoming (890)

Targeting Hypotheses (16)

Mentioning Analyses (13)

What specific molecular mechanisms link APOE4 to cholesterol dysregulation in ol

What molecular mechanisms enable microglia to neutralize OxPC-mediated neurodege

How do oligodendrocytes initiate neuroinflammation in PD when microglia are trad

What specific gene expression signatures in aging mouse white matter predict hum

Is myelin loss in AD causal or an adaptive response to neuronal damage?

Senescent cell clearance as neurodegeneration therapy

Which cell types show the most significant expression changes for neurodegenerat

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

Cell type vulnerability in Alzheimer's Disease (SEA-AD data - v2)

Cell type vulnerability in Alzheimer's Disease (SEA-AD data - v2)

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

Related Papers (20)