gene

SLC12A5

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SLC12A5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

97Connections

0Hypotheses

0Analyses

50Outgoing

35Incoming

Summary

Page for SLC12A5 — Solute Carrier Family 12 Member 5 (Potassium Chloride Cotransporter 2, KCC2)

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🧬 Gene Info

Gene Symbol	SLC12A5
Full Name	Solute Carrier Family 12 Member 5 (K⁺/Cl⁻ Cotransporter 2, KCC2)
Aliases	Potassium Chloride Cotransporter 2, KCC2
Chromosome	20q13.12
Protein Type	Transporter
Function	is a critical determinant of the polarity of GABAergic signaling, as it establishes the low intracellular chloride concentration required for hyperpolarizing GABA-A receptor responses.
Pathways	autophagy pathway
UniProt ID	Q9NPJ9
NCBI Gene ID	57468
Ensembl ID	ENSG00000124140
OMIM	607707
GeneCards	SLC12A5
Human Protein Atlas	SLC12A5
Developmental Stage	Primary Transporter
Embryonic/Early Postnatal	NKCC1
Associated Diseases	ALS, depression
Interactions	GENES
KG Connections	97 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: SLC12A5 — AlphaFold Q9NPJ9 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (9)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    SLC12A5["SLC12A5"]
    Pyroptosis["Pyroptosis"]
    Necroptosis["Necroptosis"]
    Dementia["Dementia"]
    Alzheimer["Alzheimer"]
    Als["Als"]
    SYN2["SYN2"]
    APOPTOSIS["APOPTOSIS"]
    ALZHEIMER["ALZHEIMER"]
    RNA["RNA"]
    GAD1["GAD1"]
    SYP["SYP"]
    ASTROCYTES["ASTROCYTES"]
    DEMENTIA["DEMENTIA"]
    SLC32A1["SLC32A1"]
    GRIN2A["GRIN2A"]
    PVALB["PVALB"]
    SNAP25["SNAP25"]
    Apoptosis["Apoptosis"]
    Endothelial["Endothelial"]
    Neuron["Neuron"]
    SLC12A5 -->|"therapeutic_tar"| Pyroptosis
    SLC12A5 -->|"therapeutic_tar"| Necroptosis
    SLC12A5 -->|"therapeutic_tar"| Dementia
    SLC12A5 -->|"therapeutic_tar"| Alzheimer
    SLC12A5 -->|"causes"| Als
    SLC12A5 -->|"biomarker_for"| SYN2
    SLC12A5 -->|"therapeutic_tar"| APOPTOSIS
    SLC12A5 -->|"therapeutic_tar"| ALZHEIMER
    SLC12A5 -->|"therapeutic_tar"| RNA
    SLC12A5 -->|"biomarker_for"| GAD1
    SLC12A5 -->|"biomarker_for"| SYP
    SLC12A5 -->|"therapeutic_tar"| ASTROCYTES
    SLC12A5 -->|"therapeutic_tar"| DEMENTIA
    SLC12A5 -->|"biomarker_for"| SLC32A1
    SLC12A5 -->|"biomarker_for"| GRIN2A
    SLC12A5 -->|"biomarker_for"| PVALB
    SLC12A5 -->|"biomarker_for"| SNAP25
    SLC12A5 -->|"therapeutic_tar"| Apoptosis
    SLC12A5 -->|"therapeutic_tar"| Endothelial
    SLC12A5 -->|"therapeutic_tar"| Neuron
    style SLC12A5 fill:#006494,stroke:#333,color:#e0e0e0,stroke-width:2px

Outgoing (62)

Target	Relation	Type	Str
Pyroptosis	therapeutic_target	disease	0.65
Necroptosis	therapeutic_target	disease	0.65
Dementia	therapeutic_target	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Als	causes	disease	0.65
Dementia	expressed_in	disease	0.65
Alzheimer	expressed_in	disease	0.65
ALS	causes	disease	0.65
SYN2	biomarker_for	gene	0.60
GAD1	biomarker_for	gene	0.60
SYP	biomarker_for	gene	0.60
SLC32A1	biomarker_for	gene	0.60
GRIN2A	biomarker_for	gene	0.60
PVALB	biomarker_for	gene	0.60
SNAP25	biomarker_for	gene	0.60
FLOT1	causes	gene	0.60
SLC17A6	biomarker_for	gene	0.60
SLC17A7	biomarker_for	gene	0.60
Opc	causes	cell_type	0.60
depression	causes	disease	0.60
APOPTOSIS	therapeutic_target	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
RNA	therapeutic_target	gene	0.60
ASTROCYTES	therapeutic_target	gene	0.60
DEMENTIA	therapeutic_target	gene	0.60
Apoptosis	therapeutic_target	pathway	0.60
Endothelial	therapeutic_target	cell_type	0.60
Neuron	therapeutic_target	cell_type	0.60
Astrocyte	therapeutic_target	cell_type	0.60
COP1	causes	gene	0.60
ASTROCYTES	causes	gene	0.60
MICROGLIA	causes	gene	0.60
Astrocyte	causes	cell_type	0.60
Oligodendrocyte	causes	cell_type	0.60
Neuron	causes	cell_type	0.60
Endothelial	causes	cell_type	0.60
Microglia	causes	cell_type	0.60
T Cell	causes	cell_type	0.60
APOPTOSIS	expressed_in	gene	0.60
GENES	biomarker_for	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
Necroptosis	expressed_in	pathway	0.60
Apoptosis	expressed_in	pathway	0.60
Pyroptosis	expressed_in	pathway	0.60
PYROPTOSIS	therapeutic_target	gene	0.60
Pericyte	causes	cell_type	0.60
ASTROCYTES	expressed_in	gene	0.60
AND	biomarker_for	gene	0.60
PYROPTOSIS	expressed_in	gene	0.60
App	therapeutic_target	protein	0.60

Incoming (35)

Source	Relation	Type	Str
SLC17A7	biomarker_for	gene	0.60
SLC17A6	biomarker_for	gene	0.60
GRIN2A	biomarker_for	gene	0.60
GAD1	biomarker_for	gene	0.60
SYN2	biomarker_for	gene	0.60
SYP	biomarker_for	gene	0.60
FLOT1	causes	gene	0.60
SLC32A1	biomarker_for	gene	0.60
SNAP25	biomarker_for	gene	0.60
PVALB	biomarker_for	gene	0.60
PYROPTOSIS	therapeutic_target	gene	0.60
HUB GENES	biomarker_for	gene	0.60
RNA	expressed_in	gene	0.60
PYROPTOSIS	expressed_in	gene	0.60
DEMENTIA	expressed_in	gene	0.60
AND	biomarker_for	gene	0.60
ASTROCYTES	expressed_in	gene	0.60
ALZHEIMER'S DISEASE	expressed_in	gene	0.60
GENES	causes	gene	0.60
COP1	causes	gene	0.60
AND	causes	gene	0.60
ASTROCYTES	causes	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
DEMENTIA	therapeutic_target	gene	0.60
RNA	therapeutic_target	gene	0.60
APOPTOSIS	therapeutic_target	gene	0.60
MICROGLIA	causes	gene	0.60
APOPTOSIS	expressed_in	gene	0.60
SLC17A6	associated_with	gene	0.50
SYN2	associated_with	gene	0.50
SNAP25	associated_with	gene	0.50
GRIN2A	associated_with	gene	0.50
GENES	inhibits	gene	0.50
NEURON	co_discussed	gene	0.50
slc32a1	associated_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

SLC12A5

Understanding Entity Pages

Summary

Wiki Pages (9)

SLC12A5 — Solute Carrier Family 12 Member 5 (KCC2)

CLCN10 — Chloride Voltage-Gated Channel 10

Ion Channel Dysfunction in Huntington's Disease

Ion Channel Dysfunction in Frontotemporal Dementia

GABAergic Signaling Pathway in Neurodegeneration

CLCN8 — Chloride Voltage-Gated Channel 8

slc32a1